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Biomedical subjects

A Oguri

Publications and source records attributed to A Oguri.

28 records · Page 2Linked to original sources
PubMed1994

Mutagenicities of Bangkok and Tokyo river waters.

Samples of water from the Chao Phraya river and some connected canals in Bangkok, Thailand, and from the Sumida and Ara rivers in Tokyo, Japan, were tested for mutagenicity using blue rayon to adsorb the mutagens. The samples from the Chao Phraya river and connected canals at sites located 50-150 km from the river mouth taken in May 1993 showed a mutagenicity of 87-1213 revertants per 0.05 g blue rayon extract towards S. typhimurium YG1024 in the presence of S9 mix. Samples from most sites taken in December 1993, which follows the rainy season, showed a lower mutagenicity than those taken in May, possibly due to dilution by the larger volume of water in the river and canals in December. Water samples from the Sumida river were collected in July 1993 and February 1994, and those from the Ara river in January 1994. Mutagenicity of samples from all sites of the Sumida and Ara rivers, which were located 2-30 and 2-20 km, respectively, from the river mouth was also clearly detected in the presence of S9 mix and did not differ much, being 155-748 revertants of YG1024 per 0.05 g blue rayon extract. These results demonstrated that the water in all three rivers contained some frameshift mutagens.

Frameshift Mutation↗
PubMedDate not supplied

Association between watershed zone and visual field defect in normal tension glaucoma.

PURPOSE: To evaluate the association between the watershed zone and glaucomatous optic nerve head (ONH) damage. METHODS: We performed indocyanine green fluorescence angiography with a scanning laser ophthalmoscope in 54 eyes of 27 patients with normal tension glaucoma (NTG). RESULTS: We identified 7 eyes of 8 patients (14.8%) with a watershed zone not including the ONH, 32 eyes of 20 patients (59.3%) with the watershed zone partially including the ONH, and 10 eyes of 14 NTG patients (25.9%) with the watershed zone including the ONH. Of the 27 NTG patients, 10 patients (37.0%) had different types in each eye. CONCLUSIONS: In these patients, the mean deviation of visual field indices was greater in the eye with the watershed zone, which included a larger part of the ONH than in the contralateral eye. Conversely, the eye with the greater mean deviation had a watershed zone that included a larger part of the ONH. The location of the watershed zone appeared to influence the progression of the visual field defect.

Adolescent↗
PubMedDate not supplied

Spontaneous intraocular pressure reduction in normal-tension glaucoma and associated clinical factors.

PURPOSE: To investigate the intraocular pressure (IOP) reduction in certain normal-tension glaucoma (NTG) patients and clinical factors associated with this reduction. METHODS: Fifty-four NTG patients who met the following enrollment criteria were selected: IOP <21 mm Hg during a 24-hour pressure curve and throughout the subsequent 12 months; examined every 1 to 4 months for at least 3 years with no ocular hypotensive therapy. For each patient, the eye with the higher mean IOP during the 24-hour pressure curve was selected for this study. RESULTS: Six patients had an IOP reduction which was defined as a significant decrease (P <.05) of IOP over time, determined by the Spearman rank correlation coefficient method. These 6 eyes were rated positive for subsequent IOP reduction. The IOP reduction was correlated to clinical factors by means of a logistic multiple regression analysis (LOGIST procedure using PC-SAS), which demonstrated that the larger difference between the maximum IOP and the minimum IOP during the initial 24-hour pressure curve and the absence of disc hemorrhage showed significant correlation with IOP reduction (P =.026 and P =.013, respectively). The odds ratios were 2.05 per 1 mm Hg increase of difference between the maximum IOP and the minimum IOP during the initial 24-hour pressure curve and 1.13 for the absence of disc hemorrhage. CONCLUSIONS: The current study demonstrated that a significant reduction of IOP over time is not uncommon in NTG patients. One ninth of the NTG patients in this study showed a significant IOP reduction during a 3-year follow-up period.

Adult↗