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Biomedical subjects

A Ogata

Publications and source records attributed to A Ogata.

At least 181 records · Page 10Linked to original sources
PubMed1981

Autosomal recessive prolidase deficiency. Three patients with recalcitrant ulcers.

Three patients had prolidase deficiencies. The family pedigree of these three patients suggests that this rare disorder is inherited through an autosomal recessive gene. this genodermatosis is characterized by a number of signs and symptoms referable to the skin, CNS, teeth, ears, nose, throat, eyes, bones, and joints. Among the skin changes, recalcitrant leg ulcers are the most characteristic. At this time, there is no established method of treatment of this rare disorder, but the use of dapsone was helpful in the treatment of one of our patients.

Adult↗
PubMedDate not supplied

Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein.

Experimental autoimmune thyroiditis was induced in transgenic mice (TG-3) producing human alpha-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only 1 out of 8 TG-3 mice (p < 0. 05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses.

Animals↗
PubMedDate not supplied

Functional and histological evaluation of the facial nerve in patients who have undergone hypoglossal-facial nerve anastomosis after removal of cerebellopontine angle tumors.

Facial nerve specimens removed from ten patients who underwent hypoglossal-facial nerve anastomosis for facial palsy following removal of cerebellopontine angle tumors were studied histologically. Facial nerve function prior to the anastomosis surgery and the degree of postoperative functional recovery were compared with the histological results. The recovery of facial palsy after the anastomosis surgery was excellent or satisfactory in nine patients and the endoneurium within the nerve fascicles was well-preserved. The recovery of facial palsy was poor in one patient who had severe fibrosis of the endoneurium. The histological and ultrastructural features of the facial nerve were closely related to the occurrence of facial palsy prior to tumor removal, the status of the nerve after tumor removal, and the interval between tumor removal and anastomosis surgery. Based on these histological and functional relationships, the timing and indications for anastomosis surgery are discussed.

Adult↗
PubMedDate not supplied

Urinary isatin concentrations in patients with Parkinson's disease determined by a newly developed HPLC-UV method.

Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has been found in mammalian tissues. We previously reported that exogenously administered isatin significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. In order to elucidate the relationship between isatin and Parkinson's disease, we measured urinary isatin excretions in patients with Parkinson's disease using a newly developed HPLC-UV method. The recovery of this assay was approximately 102.3% at a range from 2 to 50 nmol/ml. The Coefficient of Variance (CV) for the determination at this range was approximately 2.5% for intra-assay and 6.2% for inter-assay, respectively. There was no significant difference in urinary isatin excretion between data from men and women in healthy control. The value in young age group (19-35 years old) was not significantly different compared with that of the older age group (54-84 years old). Urinary isatin levels in patients with Parkinson's disease tended to increase in accordance to the Hoehn and Yahr criteria. This is the first study in which a significant increase in urinary isatin excretion was observed at Stage III, IV and V in patients with Parkinson's disease. Urinary isatin concentrations in drug-treated patients with Parkinson's disease (at Stage I and II) tended to decrease compared with those of patients without medication. These results demonstrated that urinary isatin excretion may serve as an endogenous diagnostic marker for the clinical severity of Parkinson's disease.

Aged↗