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Biomedical subjects

A Oberman

Publications and source records attributed to A Oberman.

At least 145 records · Page 8Linked to original sources
PubMed1976

Surgical versus medical treatment in disease of the left main coronary artery.

Data from 179 patients with a significant lesion of the left main coronary artery were reviewed to compare survival with and without bypass graft surgery. 149 patients were treated with bypass grafting. Of 38 patients treated medically, 24 were suitable for surgery but either had been evaluated before the widespread use of bypass grafting procedures or preferred medical treatment. Major prognostic factors in this group were comparable to the surgical patients. The survival-rate was consistently higher for the surgically treated group and differed significantly (P less than 0-02) for the total duration of follow-up. At twelve months, 89% of the surgical group were alive, but only 73% of the comparable medical group; at twenty-four months, survival-rates were 86% and 65% respectively. These findings, corroborated by other data, suggest that surgery prolongs life for these patients.

Aged↗
PubMed1975

Surgical versus medical treatment of occlusive disease confined to the left anterior descending coronary artery.

The results of saphenous vein bypass grafting and medical treatment were compared in 53 patients with stable angina pectoris, high grade occlusive disease confined to the left anterior descending coronary artery and normal or minimally impaired left ventricular function. Survival, incidence of myocardial infarction, relief of angina and response to exercise testing were evaluated. In the 29 surgically treated patients, followed up a mean of 24 months, there were two late deaths (7 percent) and five myocardial infarctions (17 percent). Twelve patients (41 percent) were free of angina and the majority had increased exercise performance when tested up to 18 months postoperatively. In the 24 medically treated patients, there were no deaths and one myocardial infarction (4 percent) in a mean follow-up period of 37 months. Six patients (25 percent) were free of angina. Less improvement in exercise performance was observed than in the surgically treated group. This subset of patients with isolated left anterior descending coronary artery disease has a favorable prognosis that is not enhanced by bypass grafting. Surgical treatment is more effective than medical treatment in relieving angina and improving exercise performance in the early years after coronary arteriography.

Angina Pectoris↗
PubMed1975

Double-blind studies of the clinical effectiveness of prazosin.

In separate double-blind trials, prazosin was compared with placebo and with methyldopa and placebo. In both, prazosin was well tolerated and succeeded in lowering blood pressure in patients with mild to moderate hypertension. The mean reductions with methyldopa were greater, but the difference was not statistically significant and a higher percentage of the patients in the prazosin group became normotensive.

Adult↗
PubMed1975

Sudden death in patients evaluated for ischemic heart disease.

Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occurred within 1 hour of onset of symptoms, 34% within 24 hours, and 25% in greater than 24 hours. Patients prone to sudden death were characterized as having severe multiple-vessel disease in combination with left ventricular dysfunction and disturbances in intraventricular conduction and rhythm. The best five-variable model to predict sudden death in these patients included the following variables: number of vessels greater than or equal to 70% obstructed (P less than .001); therapeutic requirement of inotropic (P less than .003) and diuretic (P less than .006) drugs; premature beats (P less than .006); and ventricular conduction defects (P less than .008). Additional variables were related significantly to the duration of the terminal episode. These data are preliminary, but indicate the possibility of identifying patients prone to sudden death.

Age Factors↗