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Biomedical subjects

A O'Brien

Publications and source records attributed to A O'Brien.

At least 91 records · Page 5Linked to original sources
PubMed1985

Testicular tumors in subfertile men: report of 4 cases with implications for management of patients presenting with infertility.

We report on 4 men attending our infertility clinic in whom seminomas developed. A review of testicular biopsies performed for investigation of subfertility in 2 patients revealed in situ and early invasive carcinoma. Infertile men have a prevalence of carcinoma in situ in the range of 1 per 100 to 200, with a high risk of progression to invasive germ cell tumor (50 per cent within 5 years of diagnosis). Biopsy is the only method of detection of the in situ lesion and, therefore, is recommended in the investigation of oligospermic and azoospermic male subjects. The surgical approach to and diagnostic sensitivity of testicular biopsy are reviewed, and the management of carcinoma in situ is discussed.

Adult↗
PubMed1985

Infectious mononucleosis. Appendiceal lymphoid tissue involvement parallels characteristic lymph node changes.

Appendectomy with mesenteric lymph node biopsy was performed in an 18-year-old man because of acute abdominal pain that was subsequently attributed to infectious mononucleosis. The appendix demonstrated intense hyperplasia of the lymphoid tissue with marked expansion of the interfollicular lamina propria by a mixed diffuse proliferation of immunoblasts including Reed-Sternberg-like forms, together with large and small lymphoid cells. Germinal centers were reactive but inconspicuous. This pattern was distinguishable from malignant lymphoma and, like the characteristic lymph node changes, may be strongly predictive of infectious mononucleosis. Involvement of gut-associated lymphoid tissue may contribute importantly to abdominal symptomatology in this infection.

Adolescent↗
PubMed1984

Evaluation of professional nursing practices in a community hospital cancer program: the methodology.

In summary, this evaluation plan is designed to assess current oncology nursing practices in a community setting. The focus of the plan is on patient problems identified in the CHCP Cancer Nursing Guidelines and the Hospice Nursing Guidelines. Critical decisions regarding which patient problems to focus on and the implementation of the evaluation plan remain with the CHCP committees. Technical assistance is provided by a CHCP Evaluation Specialist. Finally, summary reports will be generated at regular intervals so as to maximize the impact on current program development. There are several implications for this nursing evaluation plan, both immediate and long range. In the immediate, we hope that the results will help CHCP committees and individual hospitals make informed decisions about future program development. More importantly perhaps, we are for the first time in our local community identifying services central to nursing and developing base line data on the frequency of the delivery of these services. Looking into the future, we see additional implications for these studies. Currently, our evaluation system is a paper system, and paper systems are by their very nature time consuming and somewhat awkward. It is our hope that in the future information about nursing services will be registered on a computerized information system. Then, reports about the types of nursing services and amount of time spend with cancer patients could be automatically generated on a weekly basis, if so desired. However, if we are to attain this goal, we need to systematically identify common patient problems central to oncology nursing care that can be documented and studied.(ABSTRACT TRUNCATED AT 250 WORDS)

Hospitals, Community↗
PubMed1982

Correlation of the Bruininks-Oseretsky Test of Motor Proficiency with the Southern California Sensory Integration Tests.

Correlations between the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) and the Southern California Sensory Integration Tests (SCSIT) were studied by using test results obtained from a sample of 49 learning-disabled children. It was found that those SCSIT tests with a motor component correlated significantly with the BOTMP battery composite scores. The fine motor composite scores of the BOTMP reflected the greatest percentage of significant correlation with SCSIT tests. These results suggested that the BOTMP would be useful for screening children for referral to occupational therapy by educators. In addition, the high correlation of the BOTMP with the SCSIT motor tests indicated that the BOTMP may be appropriate for use in clinical research to evaluate the effectiveness of sensory integrative procedures in relation to motor function.

Child↗
PubMedDate not supplied

Should patients with a pre-operative prostate-specific antigen greater than 15 ng/ml be offered radical prostatectomy?

BACKGROUND: Patients with prostate cancer with a pre-operative prostate-specific antigen (PSA) >15 ng/ml who undergo radical retropubic prostatectomy (RRP) generally do not have a good outcome, yet may have organ-confined cancer and should be offered the option of surgery. AIM: To assess the outcome of patients who underwent RRP with a pre-operative PSA >15 ng/ml. METHODS: Thirty-four patients, mean pre-operative PSA: 25.46 ng/ml (15.03-76.6) and mean Gleason score: 6.4 (5-9) were assessed. RESULTS: Two groups were identified. Group I: 41% (14/34) have no biochemical recurrence to mean follow up of 58 months (30-106). Mean PSA: 18.8 ng/ml (15.03-25.84). Mean Gleason score: 6.1 (5-7). Clinical stage: T1c in 80%. No patient had seminal vesicle or lymph node involvement. Group II: 59% (20/34) have biochemical recurrence or died (3) from their disease to mean follow up of 66 months (36-98). Mean PSA: 28.9 ng/ml (15.28-76.6). Mean Gleason score: 6.7 (5-9). Clinical stage: T1c in 25%. Eleven patients had seminal vesicle (8) involvement or positive lymph nodes (3) or both (2). CONCLUSION: RRP seems feasible in patients whose pre-operative PSA is between 15 and 25 ng/ml with stage T1c, Gleason score < or = 7 and negative lymph node frozen section.

Adenocarcinoma↗