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Biomedical subjects

A Nowak

Publications and source records attributed to A Nowak.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

Prevention of relapse in reflux esophagitis: a placebo controlled study of ranitidine 150 mg bid and 300 mg bid.

OBJECTIVE: To compare the efficacy and safety of long term use of ranitidine 150 mg bid, 300 mg bid and placebo in prevention of endoscopic and symptomatic relapse of reflux esophagitis in an international, double-blind, placebo controlled, parallel group study. PATIENTS AND METHODS: A total of 279 patients at least 18 years old from hospital out-patient departments with healed esophagitis (grade 0) with no or mild symptoms entered the study. Patients were randomly allocated to receive ranitidine 150 mg, 300 mg placebo twice daily for 48 weeks. Patients returned for symptom assessments at eight-week intervals and for re-endoscopy every 16 weeks. RESULTS: Both ranitidine regimens were significantly more effective than placebo in preventing endoscopic and symptomatic relapse of reflux esphagitis (p = 0.003 for ranitidine 150 mg bid; P < 0.001 for ranitidine 300 mg bid). No statistically significant differences were observed in relapse rates between the two ranitidine regiments. The percentage of patients with endoscopic relapse (grade 2) after 48 weeks were 60%, 37% and 27% for placebo, ranitidine 150 mg bid and ranitidine 300 mg bid, respectively (P = 0.002 for ranitidine 150 mg bid versus placebo; P < 0.001 for ranitidine 300 mg bid versus placebo). Ranitidine was well tolerated. CONCLUSIONS: Ranitidine 150 mg bid and 300 mg bid are safe and effective treatments in the prevention of reflux esophagitis relapse.

Adolescent↗
PubMedDate not supplied

[Diagnostic difficulties in prajmaline-induced intrahepatic cholestasis].

A case of prajmalium-induced intrahepatic cholestasis is presented. A proper diagnosis was delayed because differential diagnosis did not include toxic liver damage. Pathogenetic considerations included immunological background of the disease which improved completely within one year. No clinical and biochemical complications were seen.

Arrhythmias, Cardiac↗
PubMedDate not supplied

[Interview training for patient history inquiry at the first prenatal examination: a pilot project at a women's clinic].

In view of the relevance of preventive examinations to health policy and the prophylactic value of the first meeting between physician and patient, the efficiency which which patients' histories are taken--and hence overall prenatal care--should be improved. The method adopted by duty physicians at the prenatal outpatient clinic of a community hospital furnishes an example. The examination was subdivided into four phases: 1. documentation of the current state of communication between doctor and patient (tape recordings, participatory observation, interviewing the patients and the duty physicians); 2. analysis of the interviews and the participatory observation, linguistic analysis of the history discussions; 3. topic-centered communication training of the duty physicians involved, on the basis of their own tape recordings; 4. feedback, verification of efficiency, and transfer of results to routine practice in the prenatal clinic. As early as in the fourth session changes in behavior and an increased awareness of problem areas in the course of the discussion were noted among the duty physicians. The program has proved easy to implement in practice. It enhances communication and identification for the junior physicians, and has had a highly positive overall effect.

Communication↗