[Morphologic changes in the liver of the rat after ligation of the common bile duct. Model for rapid experimental induction of cirrhosis].
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Biomedical subjects
Publications and source records attributed to A Novelli.
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The administration of medroxyprogesterone acetate to rats did not induce rapidly progressing cirrhosis in livers damage by carbon tetrachloride, as had occurred after the administration of 17-alpha-hydroxyprogesterone caprate. Even after two months' treatment with medroxyprogesterone acetate and CC14, the cirrhosis did not reach the levels obtained in a single month with the association of 17-alpha-hydroxyprogesterone and CC14.
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The treatment with CCl4 and progesterone subsequent the common biliary duct ligature induced, in the rat, after 4-5 weeks, a cirrhotic picture characterized by an early and strong biliary epithelium proliferation followed by a perilobular fibrosis with a concentric sclerosis as in true perilobular cirrhosis.
The action of monensin, an electroneutral Na/H antiport, has been studied on liver glycogen content of female rats. The results showed that monensin, when administered in vivo, is able to determine liver glycogen depletion, in agreement with the increase of glycemia and the decrease of insulinemia. Glycogen stores are reformed in 3-4 hours. Moreover, glycogen depletion is more evident in periportal areas, in agreement with "metabolic zonation" of liver carbohydrate metabolism.