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Biomedical subjects

A Noel

Publications and source records attributed to A Noel.

51 records · Page 3Linked to original sources
PubMed1983

Fluorescein angiography after retinal detachment microsurgery.

The eyes of 78 patients who underwent retinal detachment microsurgery (82 eyes) were prospectively evaluated postoperatively with fluorescein angiography. Of these 14.6% showed angiographic evidence of cystoid macular oedema (CMO.). A significantly greater risk of developing cmo was discovered in aphakic eyes (30% CMO.) as compared to phakic eyes (7% CMO.) and in eyes where the maculae were detached pre-operatively (23% CMO.), as compared to eyes where the maculae were attached pre-operatively (5% CMO.). Eyes which had undergone several surgical procedures for retinal reattachment (38% CMO.) were compared to eyes which had undergone only one surgical procedure (6.5% CMO.). It was found that 4.9% of the 82 eyes showed cellophane premacular membrane without dye leakage. A further 6% of the eyes showed premacular membranes associated with dye leakage. No statistically significant risk factor associated with the development of macular pucker was disclosed in this series.

Adolescent↗
PubMed1983

Longitudinal study of asymptomatic meningococcal carriage in two Belgian populations of schoolchildren.

In Brussels, a 15-month longitudinal survey was conducted in two primary schools, from March 1975 to May 1976, in order to analyse the dynamic of asymptomatic meningococcal carriage, during an epidemic mainly caused by serogroup B, serotype 2 Neisseria meningitidis. In the first school, which is situated in a suburban area with upper-middle socio-economic status of residents, a mean prevalence of carriers of 10 per cent, an acquisition rate of eight per 1000 months, and a mean duration of carriage of 12.4 months were observed among 158 schoolchildren aged six to 11 years old. In the second school, which is situated in a densely populated area with low socio-economic status of residents, a mean prevalence of carriers of 33 per cent, an acquisition rate of 28 per 1000 months, and a mean duration of carriage of 11.7 months were observed among 203 schoolchildren aged three to 14 years old. For both schools, the median duration of carriage was estimated at 9.4 months. The differences of prevalence and incidence of acquisition between the two schools cannot be explained by age, sex or ethnic factors and are probably related to socio familial variables. The theoretical relationship between prevalence, incidence and duration of meningococcal carriage was for the first time demonstrated in this study. The results also suggest that populations of low socio-economic status and living in densely populated areas constitute a target population for meningococcal disease prevention.

Adolescent↗
PubMed1983

Computed tomography with geometrical enlargement.

Third generation CT scanners perform examinations of small objects without employing all the detectors. Geometrical enlargement solves this problem by moving the tube-detector assembly according to the size of the object to be scanned; this improves spatial resolution, reducing both the tube current and the skin dose. Such an application for pediatric CT and small objects is of particular interest.

Child↗
PubMed1982

Atypical transmission of ABO blood groups in a French family.

A group AB mother (Mrs P.D.) gave birth to a group O female baby (C.D.). Extensive study of the blood group genetic markers in both the parents and the child, carried out on several occasions, showed nothing unusual outside the ABO system. Mrs P.D. then, gave birth to a second female baby who was also group O. Mrs P.D. had normal amounts of A, B, H and Lewis antigens in her saliva. The H, A and B agglutinability of her red cells was in the range of normal A2B group. This A2B blood group was characterized by very low A gene-specified glycosyltransferase activity in serum. Moreover this activity was undetectable in red blood cell membranes. These results are discussed in the light of various hypotheses in order to explain this unusual transmission of ABO blood group.

ABO Blood-Group System↗
PubMed1980

Cardiac catheterization: dosimetry on patients.

Our study was made on 49 patients and we used capsules of lithium fluoride. The average fluoroscopy time was 32 min. and the average cinema film length was 76.5 metres. The relationship between the entry dose, the fluoroscopy time and the length of cinema film allowed us to calculate a fluoroscopy equivalent time (F.E.T) for each patient which was of 51 min. (32 min. + 76/4) as radiation dose of one minute fluoroscopy equal radiation dose of 4 metres of cinema film. The average heart dose was 0.70 X 10(-3) X FET (GY) or 70 mr/min. There was an absence of relation of the exit dosage to the diameter of the patient and a proportionality of the heart dose to the exit dose. Furthermore the maximum eye dose recorded was 200 mrads and the maximum gonadal dose was 350 mrads.

Adolescent↗
PubMedDate not supplied

Membrane type-matrix metalloproteinases and tumor progression.

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-MMPs) are a recently discovered subgroup of intrinsic plasma membrane proteins. Their functions have been extended from pericellular proteolysis and control of cell migration to cell signaling, control of cell proliferation and regulation of multiple stages of tumor progression including growth and angiogenesis. This review sheds light on the new functions of MT-MMPs and their inhibitors in tumor development and angiogenesis, and presents recent investigations that document their influence on various cell functions.

Animals↗
PubMedDate not supplied

[Breast imaging].

Explore the source record for details and available documents.

Breast Neoplasms↗
PubMedDate not supplied

Influence of laminin or fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids: a morphometric analysis.

By microscopical observation and using an original morphometric method, we analyzed on histological sections the rate of lung colony formation after the intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as aggregates. After the injection of B16 pure spheroids, superficial lung colonies were more numerous than internal lung colonies. After the injection of mixed spheroids (B16 + 3T3 fibroblasts), the size of colony sections was increased. Addition of laminin to pure or mixed spheroids decreased the size of colony sections but increased the number of internal lung colonies.

3T3 Cells↗
PubMedDate not supplied

Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids.

By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as pure or mixed spheroids (B16 + 3T3 fibroblasts). The preincubation in vitro of pure spheroids with fibronectin significantly increased the percentages of lung section area occupied by tumors and the relative number of internal lung colonies. This effect of fibronectin was even more obvious when mixed spheroids were injected.

3T3 Cells↗
PubMedDate not supplied

[Evaluation of radiation doses during radiological tests].

The purpose of this document is to provide radiologists with a simple, but realistic means of determining the individual dose delivered to a patient during a radiological examination both in the region under investigation and at any other particularly sensitive organs. Fourteen types of examinations were considered corresponding to those most frequently carried out in France. The choice of examinations and methods of taking the films approaches as closely as possible, the average situations, and the frequency of different techniques is influenced by the results of a national study of radiodiagnostic examinations carried out in France in 1982. In the first section, the influence on the radiation dose of varying different physical parameters and techniques is analysed, with an aim of defining the limits of validity of the presented dosimetric values and the possible adaptation of these values to any individual situation, which is slightly different from these considered in this study. The second section describes the model used for determining the absorbed dose presented in the tables, concerning each type of examination, as well as bibliographic references referring to methods and results of determining the dose. The suggested calculation model may be used as a base for dose estimation for other types of examination.

Abdomen↗