Biomedical subjects

A Nishigaki

Publications and source records attributed to A Nishigaki.

22 records · Page 2Linked to original sources

PubMedDate not supplied

Further evidence concerning catecholamine metabolism in polycystic ovary syndrome following Gn-RH administration.

The role of catecholamine activity in the GnRH-LH system among cases of polycystic ovary syndrome was investigated by high-performance liquid chromatography using an electrochemical detector. We measured plasma levels of catecholamine metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylacetic acid (DOPAC), in relation to LH-RH administration in 23 women with polycystic ovary syndrome. MHPG concentrations were significantly higher in polycystic ovary syndrome patients than in ten control subjects in early follicular phase. The peak values of LH after LH-RH administration were significantly correlated with plasma MHPG concentrations. These data suggest that an excess of norepinephrine is present in polycystic ovary syndrome and that the hypophyseal response to LH-RH administration is correlated with catecholamine, especially norepinephrine activity.

3,4-Dihydroxyphenylacetic Acid↗

PubMedDate not supplied

On the relationship between endocrine and ovulatory abnormalities, and polycystic ovaries as diagnosed by ultrasonography.

The present study was undertaken to investigate the relationship between serum testosterone levels, the menstrual cycle, and polycystic ovaries as shown by ultrasonographic methods. The patients were divided into four groups: (1) cases with normal-appearing ovaries and with regular menstruation (control); (2) cases with normal ovaries on ultrasound, but with abnormalities of the menstrual cycle (MA); (3) cases with polycystic ovaries, but normal menstrual cycle (PCO); (4) cases with both polycystic ovaries and menstrual abnormalities (PCOMA). The results were as follows. (1) The ovarian area was significantly larger in the PCOMA group than in the control group. (2) The number of cases with elevated LH (greater than 30 mIU/mL) was significantly higher in the PCOMA group than in the other groups. (3) In comparison with controls, the percentage of cases with LH/FSH ratios greater than 3.0 was significantly higher in all three groups. (4) The estrone/17 beta-estradiol ratio for the PCOMA group was significantly greater than those of the other groups. (5) The testosterone levels of the PCO and PCOMA group were significantly greater than the control value. (6) The percentage of endocrine criteria (LH greater than 30 mIU/mL or LH/FSH ratio greater than 3.0, estrone/17 beta estradiol ratio greater than 1.0 testosterone greater than 75, greater than 100, and greater than 125 ng/dL) for PCOMA was significantly higher than that of the MA group and the control group, but not significantly greater than the PCO group. It is suggested that morphological changes in the ovaries show a closer correlation with abnormalities of endocrine function than does the presence or absence of abnormalities of the menstrual cycle.

Female↗

PubMedDate not supplied

Changes in plasma catecholamines and pulsatile patterns of gonadotropin release in subjects with a normal ovulatory cycle and with polycystic ovary syndrome.

Plasma LH levels in women and female laboratory animals fluctuate. Since catecholamines play a role in gonadotropin secretion, we investigated the possible correlation between catecholamine metabolites and pulsatile patterns of gonadotropin release by measuring two catecholamine metabolites, MHPG and DOPAC. LH levels had a pulsatile pattern, and the levels of MHPG fluctuated. The average of LH and MHPG in polycystic ovary syndrome was significantly higher than that of a normal ovulatory cycle, and the average fluctuation of LH and MHPG in polycystic ovary syndrome was also significantly greater than that in a normal ovulatory cycle. There may be a correlation between the pulsatile pattern of gonadotropin and catecholamine activity, particularly adrenergic activity. It is suspected that adrenergic activity may correlate with the pulsatile pattern in polycystic ovary syndrome.

3,4-Dihydroxyphenylacetic Acid↗

PubMedDate not supplied

Peripheral catecholamine metabolites and menstrual irregularity in patients with polycystic ovaries.

OBJECTIVE: To investigate the catecholamine status of patients with polycystic ovary syndrome. DESIGN: Three parallel groups with polycystic ovary were diagnosed by ultrasound: (a) 5 patients with regularly ovulatory menstruation; (b) 10 with anovulatory menstruation; (c) 13 with secondary amenorrhea who responded to progestagen with withdrawal bleeding. Blood samples for measurement of LH, testosterone, and catecholamine metabolites were drawn during cycle days 4-7. RESULTS: (1) Serum LH and testosterone of the patient groups (b) and (c) were significantly higher than those of controls. (2) Plasma 3,4-dihydroxyphenylglycol (DOPEG) and the DOPEG/DOPAC ratio were elevated in patients, and DOPAC levels were reduced. However, there was no significant difference of catecholamine metabolites among the three patient groups. CONCLUSIONS: The androgen status in polycystic ovary diagnosed by ultrasound is correlated, but catecholamine status is not correlated, with the menstrual irregularity of polycystic ovary syndrome.

3,4-Dihydroxyphenylacetic Acid↗