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Biomedical subjects

A Nishida

Publications and source records attributed to A Nishida.

174 records · Page 10Linked to original sources
PubMed1979

Protective effect of cetraxate, a new antiulcer drug, against serotonin-induced ulcer.

Cetraxate increased gastric mucosal blood flow and inhibited the decrease in blood content of the rat gastric preparation, as induced by serotonin. In addition, this compound decreased the inside pressure of the rat stomach and the tone of the rat fundus strip and inhibited the increase in gastric emptying rate induced by serotonin. Further effects of the drug were decrease in the tone of isolated rabbit aorta and inhibition of platelet aggregation as induced by thrombin. Decrease in the vascular resistance was apparently related to increase in the gastric blood flow. These experimental results suggest that the antiulcer effect of cetraxate is due to the improvement of blood circulation in the gastric mucosa.

Animals↗
PubMedDate not supplied

Ferritin immunohistochemical study on pontine nuclei from infants with pontosubicular neuron necrosis.

Immunohistochemical ferritin staining was performed on pontine nuclei of the brains of 17 infants with pontosubicular neuron necrosis (PSN), aged 23 to 42 weeks of gestation. Ferritin-positive cells were increased in cases of karyorrhexis with spongy changes and gliosis, but not in those of selective karyorrhexis. Ferritin-positive cells were more increased in the cases with extensive karyorrhectic neurons. Iron may be released to the damaged pontine tissue as a catalyst and microglia may play an important role in the repair of the tissue.

Astrocytes↗
PubMedDate not supplied

Development of ferritin-containing cells in the pons and cerebellum of the human brain.

The distribution and development of ferritin-containing cells were studied in the pons and cerebellum of human fetuses up to adults, using an immunohistochemical method. The predominant cell type labeled with antiserum to ferritin in the pons and cerebellum was morphologically oligodendrocytes. In the pons, positive cells appeared at 21 weeks of gestation in the reticular formation, and longitudinal and transverse fibers, and at 25 weeks of gestation in pontine nuclei. They increased with age from 33 weeks to infancy. In the cerebellum, positive cells appeared at 25 weeks of gestation in the cerebellar white matter and granular layer. They increased from 29 to 40 weeks of gestation in the white matter, and to childhood in the granular layer. The time of appearance of positive cells in the pons and cerebellum is earlier than in the cerebrum, like myelination. This development of ferritin-positive glia may be related to maturation of oligodendrocytes as well as being the basis of myelination.

Adolescent↗
PubMedDate not supplied

Developmental expression of copper, zinc-superoxide dismutase in human brain by chemiluminescence.

Copper, zinc-superoxide dismutase (Cu,Zn-SOD) activities were determined by the chemiluminescence method using the cypridina luciferin analog (MCLA) in 22 human brains from fetuses to adults. Cu,Zn-SOD activity of the cerebral cortex and white matter increased from 15% in fetuses to 50% of adult levels in neonates. The activity of the white matter was higher than that in the cortex in the fetal period, but was essentially the same as those of the cortex in the postnatal period. Cu,Zn-SOD activity in the central nervous system was highest in the spinal cord and higher in the order pons, medulla oblongata > cerebellum, midbrain, thalamus > putamen, pallidum and cerebrum. These low activities may be related to the vulnerability of cerebral cortex and white matter in premature infants.

Adult↗