Search PubMed⌕ Search

Biomedical subjects

A Nicoll

Publications and source records attributed to A Nicoll.

At least 145 records · Page 8Linked to original sources
PubMed1986

The child health clinic: results of a new strategy of community care in a deprived area.

Substantial changes were made in the organisation of a child health clinic serving an underprivileged population in Nottingham. A community paediatric team approach was adopted, routine medical checks were reduced, and referrals from elsewhere (including parents) were encouraged. The changes resulted in an older and more deprived population of preschool children being seen by the clinic doctors. More treatable medical disorders were detected with this approach.

Age Factors↗
PubMed1985

Deprivation hands and feet.

A survey of preschool children in three inner city day nurseries serving deprived areas found 13 children with pink oedematous hands and feet--'deprivation hands and feet'. The children and their families were compared with similar children in the nurseries. Growth and development were poor compared with accepted norms, but not notably different from controls. The families of the affected children were exceptional in being at a considerable social disadvantage. Other children in the families of these children also showed the sign.

Child Development↗
PubMed1984

The readability of health-care literature.

The readability of health-related pamphlets intended for the British public was compared with that of English national newspapers. Many of the pamphlets were found to be less readable than desirable. Pamphlets issued by government departments (principally the Department of Health and Social Security) were assessed as particularly difficult to read, but some specialist and commercially produced pamphlets also gave cause for concern. A small number of specially produced 'baby books' were found to have more suitable levels of prose difficulty. It is suggested that readability formulae can be a useful tool in the initial assessment of health education literature.

Child↗
PubMed1982

Relationships between the metabolism of high-density and very-low-density lipoproteins in man: studies of apolipoprotein kinetics and adipose tissue lipoprotein lipase activity.

In order to gain further insight into the relationship between high-density lipoprotein (HDL) metabolism and plasma triglyceride transport, measurements were made of HDL cholesterol concentration, apoprotein (apo) AI and AII metabolism, very-low-density-lipoprotein (VLDL) apo B metabolism, and heparin-elutable adipose tissue lipoprotein lipase (LPL) activity in seventeen subjects with a wide range of plasma triglyceride concentrations (0.8-25 mmol/l). The fractional catabolic rate (FCR) of VLDL apo B was directly related to LPL activity (r = +0.80), providing evidence that the activity of the enzyme in adipose tissue is a determinant of the rate of lipolysis of VLDL in man. HDL cholesterol concentration was a positive function of both VLDL apo B FCR (r = +0.74) and LPL activity, a finding consistent with previous evidence for the origin of a proportion of HDL cholesterol from 'surface remnants' liberated during VLDL catabolism. THe FCRs of both apo AI and apo AII were inversely related to VLDL apo B FCR (AI, r = -0.52; AII, r = -0.69) and to LPL activity. The synthetic rate of ap AII, but not that of apo AI, was positively correlated with VLDL apo B synthesis (r = +0.7 1). Thus, the metabolism of the major proteins of HDl in man appears to be closely associated with VLDL metabolism.

Adipose Tissue↗
PubMed1982

Supplementary feeding and jaundice in newborns.

In a survey it was found that the majority of full-term breast fed infants receive supplementary feeds of water, dextrose solution or infant formula during the first few days of life. Breast fed babies receiving water or dextrose supplements had higher plasma bilirubins on the sixth day of life than bottle fed infants. Supplementation with water or dextrose did not reduce the hyperbilirubinaemia of term, breast fed infants. Since it may prejudice the establishment of breast feeding, we suggest that the practice is abandoned.

Animals↗
PubMed1981

Flux of plasma lipoproteins into human arterial intima. Comparison between grossly normal and atheromatous intima.

Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isolated from saline extracts of washed intima in the density ranges less than 1.006 g/ml, 1.006-1.019 g/ml and 1.019-1.063 g/ml [intimal VLDL, intermediate-(IDL) and low density lipoprotein (LDL), respectively]. Specific radioactivity of apo B was measured in corresponding plasma protein fractions. In atheromatous intima, minimum influx rates of VLDL-apo B [12.1 +/- 4.3 (SEM) ng . cm-1 . h-1] and IDL-apo B (13.6 +/- 5.1) over 24 h were significantly higher than fluxes of VLDL-apo B (1.2 +/- 0.34) and IDL-apo B (1.4 +/- 1.1) into normal intima (P less than 0.05). Minimum influx rate of LDL-apo B was also significantly higher in atheromatous intima (196 +/- 39) compared with normal intima (25.8 +/- 13.5, P less than 0.01) and was 16-18 fold higher than corresponding VLDL- and IDL-apo B fluxes in both types of intima. Collagenase digestion of intimal samples after saline extraction yielded further significant mass of VLDL but this fraction had little radioactivity compared with saline extractable VLDL.

Apolipoproteins↗