Biomedical subjects
A Nicholls
Publications and source records attributed to A Nicholls.
The source of a gastric secretory inhibitor from human saliva.
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Blood volume in malignant disease: case studies in 86 females.
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Inhibition of gastric acid secretion by a purified bacterial lipopolysaccharide.
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Concentration and partial characterization of human salivary gastrone.
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Inhibition by gastrone of rat gastric acid secretion maximally stimulated by 2-deoxy-D-glucose.
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The effect of cytotoxic drugs on serum albumin in the rat.
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Comparison of the growth of the Ehrlich ascites tumor in male and female mice.
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The effect of two different gastrones on acid secretion by the rat in vivo and by isolated rat gastric mucosa.
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The effect of large doses of cytotoxic drugs on the blood volume of the rat.
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Rat gastric acid secretion in response to graded subcutaneous doses of 2-deoxy-D-glucose.
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Accuracy of survey radiographic diagnosis of intervertebral disc protrusion in dogs.
To assess the diagnostic accuracy of survey radiography for canine thoracolumbar intervertebral disc protrusion, survey radiographs (lateral and ventrodorsal) of 64 dogs with surgically-confirmed thoracolumbar intervertebral disc protrusion, 51 dogs with negative myelograms and 29 dogs with various spinal conditions other than disc protrusion were reviewed by three independent observers who were unaware of any clinical information. There were marked differences in observer performance for diagnosis of intervertebral disc protrusion, although there were no significant differences in intraobserver diagnostic accuracy for small vs. large dogs. Accuracy of observers for determining sites of intervertebral disc protrusion using survey radiography was in the range 51-61%. All observers had low accuracy for identification of second sites of intervertebral disc protrusion. The most useful radiographic sign, narrowed intervertebral space, had only moderate sensitivity (range 64-69%) and moderate predictive value (range 63-71%) for intervertebral disc protrusion. Vacuum phenomenon was an infrequent but accurate sign of intervertebral disc protrusion. Recognition of multiple radiographic signs of intervertebral disc protrusion at one site was associated with increased accuracy of diagnosis. No observer was accurate enough to justify attempting targeted surgical treatment of intervertebral disc protrusion without myelography.
Chronic renal failure in old age.
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