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Biomedical subjects

A Nemeth

Publications and source records attributed to A Nemeth.

62 records · Page 4Linked to original sources
PubMed1982

Natural history of children with alpha 1-antitrypsin deficiency and neonatal cholestasis.

Ten children with alpha 1-antitrypsin deficiency, phenotype PiZ, and neonatal cholestasis were followed to the ages of 4-20 years. Standard liver function tests, urinary bile acid excretion and liver morphology were investigated within one week and the results were compared. Three patients had morphological signs of liver cirrhosis and one of these had clinical signs as well. Compared to healthy children of the same age urinary bile acid excretion was increased only in those with morphologically confirmed liver cirrhosis. Although most of the other patients had some minor histological changes in the liver biopsies, the normal urinary bile acid excretion was in accordance with their excellent general clinical state and is interpreted as a short-term favourable prognostic sign.

Adolescent↗
PubMed1982

Liver disease in children with alpha 1-antitrypsin deficiency without neonatal cholestasis.

Thirteen children with alpha 1-antitrypsin deficiency (8 PiZ and 5 PiSZ) were investigated at ages ranging from 4 to 6. None had had neonatal cholestasis. Nine, mainly the PiZ individuals, had increased serum concentration of transaminases. Liver biopsy was performed in 7 patients with increased serum levels of transaminases. One of these patients had cirrhosis and 4 had moderate to severe fibrosis. The results indicate that alpha 1-antitrypsin deficient individuals, also without neonatal cholestasis syndrome run a high risk of developing serious liver disease, already in childhood. The cirrhotic patient was the only one who had increased excretion of bile acids in urine.

Bile Acids and Salts↗
PubMed1981

[Anatomo-surgical considerations on the indications and technic of Patey's radical mastectomy].

After expressing some considerations on "conservative operations" and "limited resections" for cancer of the breast, the Authors describe the technique of performance of modified Patey's radical mastectomy. This operations is less destructive than Halsted's but nevertheless gives a sufficient guarantee of radicality, as confirmed by an examination of the most recent literature. The procedure also allows better aesthetic results to be achieved with subsequent plastic surgery. From the data reported in literature on comparison between the five-year results after radical mastectomy according to Halsted and modified radical mastectomy according to Patey, it can be seen that the survival rate is roughly the same. The local relapse rates both in the cases with lymph node involvement are likewise similar, irrespective of technique. This evidences that Patey's operation is correctly indicated in carcinomas of the breast not yet locally advanced.

Breast Neoplasms↗
PubMedDate not supplied

Early case of acquired immunodeficiency syndrome in a child from Zaire.

An eight-year-old child from Zaire died in Sweden in 1982 after a clinical course compatible with the acquired immunodeficiency syndrome (AIDS). In 1975, at the age of 5 months, the infant had an acute viral infection with a rash; this illness was followed by a chronic cough. During the course of the disease he had recurrent septicemia, fever (frequently with miliary lung infiltrates), disseminated lymphadenopathy, hepatosplenomegaly, candidiasis, and diarrhea. Late in the illness the child developed lethal disseminated disturbances of the central nervous system. Immunologic investigations revealed a pronounced hypergammaglobulinemia, normal C3 but low C4 values, decreased number of T-lymphocytes, and decreased lymphocyte stimulation with T-cell and B-cell mitogens. Samples of serum taken in 1981 and 1982 were analyzed and found to be positive for antibodies to HTLV-III virus. The course of the disease in this child was more prolonged than most of the pediatric cases described earlier. It is likely that this child developed AIDS early in 1975, long before the AIDS epidemic was apparent in the United States.

Acquired Immunodeficiency Syndrome↗