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Biomedical subjects

A Nauman

Publications and source records attributed to A Nauman.

At least 37 records · Page 2Linked to original sources
PubMed1967

Total and free triiodothyronine in human serum.

A reliable method has been developed for the determination of total serum T3, dialyzable fraction (DFT3), and absolute concentration of free T3 (AFT3). Total T3 values (mean +/- SD) were: healthy euthyroid subjects, 0.33 +/- 0.07 mug per 100 ml; hyperthyroid patients, 0.71 +/- 0.1 mug per 100 ml; hypothyroid, 0.10 +/- 0.03 mug per 100 ml. Values (mean +/- SD) for DFT3 in these groups were 0.46 +/- 0.14%, 0.78 +/- 0.17%, and 0.16 +/- 0.08%, respectively. Calculated values for AFT3 were: 1.51 +/- 0.4 mmug per 100 ml, 5.00 +/- 0.6 mmug per 100 ml and 0.24 +/- 0.1 mmug per 100 ml, respectively. Dilution of serum before dialysis lowered estimated DFT3 values. Enrichment of serum with labeled T3 in the range examined did not affect DFT3. However, DFT3 was increased by addition of Merthiolate to serum in concentration 1: 10,000 due to displacement of T3 from thyroxine-binding globulin to albumin. The data suggest that triiodothyronine may play a considerably more important role in normal and pathological physiology, as evidenced by kinetic analysis using these data. A metabolic role for T3 equal to that of T4 is indicated.

Journal Article↗
PubMedDate not supplied

[Regulation of triiodothyronine levels in fatty tissue in obese patients].

Specific activity of T4-5'-deiodinase, the enzyme which catalyze peripheral production of triiodothyronine (T3) from thyroxine (T4) has been evaluated in the subcutaneous adipose tissue of obese patients. In lean healthy women (BMI less than 21) mean activity of T4-5'-D was found to be 122 +/- 29.4 fmol T3/mg of protein/min and was higher then respective activity of the enzyme in adipocytes of patients with mild obesity (22 less than BMI less than 30) where the mean was 92.14 +/- 18.05 fmol T3/mg/min. The activity of T4-5'-D was significantly decreased in patients with severe obesity (BMI less than 30) when compared with respective activity of the enzyme found in controls (47.36 +/- 18.4 fmol T3/mg/min vs 122.4 +/- 29.4 fmol T3/mg/min; p less than 0.01). As T4-5'-D in human adipose tissue has been previously characterized as type II of the enzyme, diminished activity found in obese subjects means that thyroid metabolic activity of adipocyte is decreased. Such a state would lead to antilipolytic action of catecholamines in obesity.

Adipose Tissue↗