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Biomedical subjects

A Naud

Publications and source records attributed to A Naud.

7 recordsLinked to original sources
PubMed1999

[Recurrence and satisfaction levels following onysectomy with or without phenolization].

OBJECTIVE: To compare recurrence and satisfaction levels among patients undergoing onysectomy with phenolization (OP) and without phenolization (OS). DESIGN: Retrospective cohort study. SETTING: Family practice unit. PARTICIPANTS: All patients (N = 35) undergoing onysectomy between September 1992 and May 1993, and between January 1996 and February 1997. MAIN OUTCOME MEASURES: Type of onysectomy (OP or OS) was taken from the patient's medical record. A telephone interview was used to determine whether patients had experienced recurrence; satisfaction was measured retrospectively at diagnosis, at time of surgery, and after surgery using a five-point scale (very unsatisfied to very satisfied). RESULTS: Among the 30 patients interviewed by telephone, four of the six patients in the OS group experienced recurrence, and four of the 24 patients in the OP group experienced recurrence. (Fisher's exact test, P = .007). In the OS group, satisfaction levels at diagnosis, during surgery, and after surgery were 4.7, 4.5, and 4.2, respectively. In the OP group, satisfaction levels at these three points were 4.3, 4.2, and 4.4, respectively. Notwithstanding technique used, a connection was noted between recurrence and satisfaction level at the time of the telephone interview (repeated measures test, P = .036). CONCLUSION: In general medicine, onysectomy with phenolization could be the treatment of choice for ingrown toenails.

Adult↗
PubMed1997

Diagnostic accuracy of urinary cytology, and deoxyribonucleic acid flow cytometry and cytology on bladder washings during followup for bladder tumors.

PURPOSE: We evaluated the diagnostic accuracy of cytology on urine and bladder washings, and deoxyribonucleic acid (DNA) flow cytometry on bladder washings compared to cystoscopy during followup for bladder tumors. MATERIALS AND METHODS: A cross-sectional analysis was performed on 166 patients with a history of bladder tumor for the initial visit when cytology and DNA flow cytometry results were available for urine and bladder washing samples. There were 114 bladder tumor events and 52 negative controls (normal cystoscopy). A prospective study was conducted among the 66 patients with no tumor detected by cystoscopy at the initial visit and for whom the 3 test results were available. The patients were followed from this visit until tumor recurrence or the end of the followup period. Cytological examination was considered positive only when interpreted as malignant. Suspicious examinations were considered negative for the purpose of our study. RESULTS: Sensitivity and specificity of urinary cytology were 59 and 85%, respectively. Sensitivity was increased to 66% using bladder washing cytology whereas specificity was moderately decreased to 83%. The sensitivity and specificity of DNA aneuploidy were 45 and 87%, respectively. Inclusion within the aneuploid category of hyperdiploid samples (defined as more than 7% of cells in the S + G2M phase) increased sensitivity to 77%, while specificity decreased to 42%. Kaplan-Meier analysis of tumor-free survival in patients initially free of bladder cancer at cystoscopy showed an inability of DNA flow cytometry to predict recurrence, whereas positive urine or bladder washing cytology predicted a shorter time to recurrence (log-rank test p <0.01). CONCLUSIONS: These results show that DNA flow cytometry and cytology on bladder washing samples add little information to that obtained from voided urine cytology.

Cross-Sectional Studies↗
PubMed1995

[Ipsilateral adrenalectomy in the surgical treatment of renal carcinoma].

OBJECTIVES: To assess the value of ipsilateral adrenalectomy during radical nephrectomy for the treatment of renal cell carcinoma as a function of preoperative computed tomography findings. METHODS: Between May 1985 and June 1994, 194 patients underwent radical nephrectomy for renal cell carcinoma in our institution. Preoperative radiological reports and postoperative pathological reports were reviewed for 185 patients. RESULTS: 148 patients underwent abdominal computed tomography before surgery. 94 adrenalectomies were performed in this group of patients. None of the 77 patients in whom computed tomography showed a normal adrenal gland had adrenal metastasis on the definitive histological examination. 17 patients had an adrenal mass on computed tomography, 3 of which proved to be neoplastic. Preoperative CT had a sensitivity of 100%, a specificity of 82%, a positive predictive value of 18% and a negative predictive value of 100%. The 185 files reviewed included 114 adrenalectomies, including 4 adrenal glands invaded by renal cell carcinoma (3.5%). In these 4 cases, the smallest diameter of the renal tumour was 4 cm and the minimum pathological stage was T3. CONCLUSIONS: It therefore appears justified not to perform adrenalectomy during nephrectomy, in the presence of a renal tumour and negative adrenal computed tomography.

Adenocarcinoma↗