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Biomedical subjects

A Nash

Publications and source records attributed to A Nash.

68 records · Page 4Linked to original sources
PubMedDate not supplied

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.

A major aim in immunology has been to understand how the immune system evokes characteristic responses to infection, foreign tissue grafts and tumours. The current view of immunoregulation is based mainly on studies of lymphocyte subsets, either in vitro or by adoptive transfer to irradiated recipients. Many reagents are available for defining T-cell subsets, but only recently have there been helper T-cell-specific antibodies against the mouse equivalent of the Leu3/T4 (man) and W3/25 (rat) antigens. It is clear that monoclonal antibodies will eventually replace antilymphocyte globulin for immunosuppression in organ grafting, but although there has been some clinical success, most monoclonal reagents cause only transient reductions in their target cells in vivo. This uncertainty in the potency of monoclonal antibodies has led some workers to consider them as targeting agents for such highly cytotoxic drugs as ricin A (ref. 21). We show here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.

Animals↗
PubMedDate not supplied

Referring patients for domiciliary care.

This article attempts to identify some of the reasons why patients who meet the referral criteria of domiciliary palliative nursing care services are not referred. A study was conducted among district nurses and GPs which highlighted that a 'conspiracy of silence' still existed between patients, professionals and families. A desire to manage patients themselves and a misunderstanding of the work of Macmillan nurses were also reported. Some recommendations for change are made.

Community Health Nursing↗
PubMedDate not supplied

Oncology: the role of the Macmillan nurse.

Misunderstandings and misconceptions about the role and function of Macmillan nurses have been apparent for some time. In this paper, Ann Nash traces the development of the Macmillan clinical nurse specialist, and offers guidelines and advice to health authorities and others on appropriate utilisation of the Macmillan service.

Community Health Nursing↗
PubMedDate not supplied

Lack of relationship between parity and level of carcinoembryonic antigen in women with breast cancer.

Women with high parity appear to be protected against the development of breast cancer. It has been suggested that those tumours which secrete carcinoembryonic antigen (CEA) are destroyed in women who develop cell-mediated immunity to embryonic antigen at the time of pregnancy or childbirth at an early age. A study of 335 patients with breast cancer was designed to test the hypothesis that circulating levels of CEA would be lower in women with high parity and an early age at first pregnancy or live birth. CEA levels were higher if measured in the presence of tumour metastasis. There was no association between CEA levels and parity, age at first live birth, age at diagnosis or cigarette smoking. Thus we have no evidence that breast cancers which express embryonic antigens, such as CEA, are preferentially destroyed by an immune response which has arisen from embryonic inoculation during or around an early childbirth.

Adult↗