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Biomedical subjects

A Naselli

Publications and source records attributed to A Naselli.

35 records · Page 2Linked to original sources
PubMed1979

The silent carrier of beta thalassemia: interaction with the typical beta thalassemic trait.

The case of a girl affected by a Colley's disease of moderate severity is reported. A brother and a sister had levels of Hb F respectively of 18% and 45%. The father showed all the hematological signs of heterozygous thalassemia. The mother, however, was normal so far as osmotic fragility, red cell morphology, and Hb A2 level are concerned. In vitro hemoglobin chains biosynthesis was performed in all the subjects. Both the parents showed an alfa/non alfa ratio typical of beta thalassemia. Therefore, the mother has to be considered a "silent" carrier of the trait. The daughters and the son have a less severe Colley disease originating by such a double heterozygosity.

Child↗
PubMedDate not supplied

Statural growth and skeletal maturation in rheumatic prepubertal children treated with a third generation glucocorticoid (deflazacort) versus prednisone. An interim study.

Deflazacort, a new glucocorticoid (DFZ) which has recently become available, is known to have lower adverse effects on the skeletal metabolism and is expected to inhibit growth to a lesser extent in long-term treated children than earlier cortisone analogues. With the aim of verifying this hypothesis a multicenter study was planned to compare the effects of deflazacort and prednisone on linear growth and skeletal maturation in a group of prepubertal children requiring chronic steroid therapy. The data presented in this interim analysis refer to 24 children (11 females and 13 males ranging in age from 2.4 to 11.8 yrs) with rheumatoid arthritis (18), systemic lupus erythematosus (4) or dermatomyositis, selected from the total sample of 65 subjects included in the trial. They were randomly allocated to DFZ or PDN treatment and received the minimum effective dose of either steroid for at least 6 months per year. Longitudinal height measurements were obtained with standard instruments and techniques, and the bone age was assessed according to Greulich and Pyle. The following indicators of growth retardation were considered: bone age delay (difference between bone age and chronological age), statural age delay (statural age, with respect to the 50th percentile minus the chronological age) and statural age loss (statural age with respect to the individual height percentile at the first observation minus the chronological age).(ABSTRACT TRUNCATED AT 250 WORDS)

Age Determination by Skeleton↗
PubMedDate not supplied

[A comparative study of skinfold thickness and bioelectric impedance analysis in the evaluation of body composition of children and adolescents].

A comparative study as carried out between skin-fold thickness tests and bioelectric impedance analysis (BIA) to assess the validity of the latter as a method for evaluating body composition in childhood and youth. The percentage values of total body fat obtained using both methods in 117 boys and girls aged between 8 and 14 appear to be significantly correlated (p less than 0.01) in both sexes (males: r = 0.891; females: r = 0.830) and in each group of subjects subdivided according to stage of puberal development (8-11 years: r = 0.905; 12-14 years: r = 0.864) or the degree of physical activity performed (active: r = 0.880; sedentary: r = 0.915). The results of the study confirm that BIA represents a valid and reliable method to analyse body composition even during circumpuberal development in phase opposition. Moreover, BIA provides an estimate of total body fat which is independent of the differences in distribution between surface and deep deposits.

Adipose Tissue↗