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Biomedical subjects

A Nagy

Publications and source records attributed to A Nagy.

At least 343 records · Page 19Linked to original sources
PubMed1979

Effects of zimelidine, a selective 5-HT uptake inhibitor, on serum prolactin levels in man.

The levels of serum prolactin were studied both after an acute intake of zimelidine and during a treatment period of 3--7 weeks. No significant changes in basal serum prolactin levels were seen after single oral doses of zimelidine (100 mg) in healthy volunteers during an investigation period of 12 h. Serum prolactin concentrations remained well within the pretreatment levels also during a continuous treatment of depressive patients with zimelidine up to 150 mg orally b.i.d. It is concluded that clinical doses of the selective 5-HT uptake inhibitor zimelidine does not exert any significant effect on serum prolactin levels.

Adult↗
PubMed1979

Single versus divided daily dosages of clomipramine. Plasma concentration and clinical effect.

Sixteen depressed patients have been treated with a daily dose of 150 mg clomipramine for 20 days. Every patient received the total dose at night for 10 days and three times daily for 10 days according to a double-blind, cross-over design. No differences were noted between the two dose regimens, either regarding the clinical effect or the side effects. The plasma level ratio of parent drug to demethylated metabolite was higher on single than multiple doses.

Adolescent↗
PubMed1979

Epilepsy and brain abscess.

Among 22 children who had recovered from brain abscess, 9 later developed epilepsy. Epilepsy developing as a consequence of brain abscess depends on the length of the catamnestic period and the localization of the abscess. The appearance of epilepsy is more frequent after frontal and temporal abscesses and in cases presenting symptoms in the acute phase of the abscess. Since epilepsy may develop years or even decades after recovery from the brain abscess, it is recommended to keep the patient under control for years.

Adolescent↗
PubMed1979

Ion content of synaptic vesicles.

Proton induced X-ray emission analysis measurements were performed to determine the P, S, K, Ca Fe, Ni, Cu and Zn ion content of presynaptic vesicles prepared from guinea-pig brain cortex. The number of different ions per single vesicle is calculated using the results of the additional protein content determinations. The ion contents of cholinergic and adrenergic vesicles are compared.

Acetylcholine↗
PubMed1978

The kinetics of imipramine-N-oxide in rats.

Rats were given imipramine-N-oxide as single intramuscular injection and then as repeated oral doses. Imipramine-N-oxide and the metabolites imipramine and desipramine were analysed in the blood cells, plasma and brain tissue. The concentration of imipramine-N-oxide increased simultaneously in the brain and blood, reaching a peak 45 minutes after a single dose. Imipramine was the quantitatively predominant metabolite in the blood cells and brain, while desipramine reached a higher concentration than imipramine in the plasma. Samples taken at different times after oral doses during continuous treatment showed fairly constant concentrations of imipramine-N-oxide and desipramine in the brain, whereas the concentration of imipramine was more fluctuating.

Administration, Oral↗
PubMed1977

The demethylation of imipramine and clomipramine as apparent from their plasma kinetics.

The demetylation of imipramine and clomipramine was studied after administration by different routes of single doses of clomipramine hydrochloride and multiple doses of clomipramine as well as imipramine hydrochloride. Five healthy volunteers received 1 mg of clomipramine hydrochloride/kg body weight as single oral and intramuscular doses on different occasions for the purpose of studying the plasma levels of clomipramine and the desmethylclomipramine formed. Desmethylclomipramine was found in the plasma in four of the subjects after oral intake but only in one subject after intramuscular injection. The peak levels of clomipramine were considerably higher after intramuscular than after oral administration. The half-lives of clomipramine after oral administration ranged from 11.6-35.8 h (M = 20.8 +/- 4.0) and after intramuscular administration from 20.1--39.6 h (M = 24.7 +/- 3.7). Twenty subjects received either imipramine or clomipramine both orally and intramuscularly during a period of 3 weeks in a crossover design. The plasma levels of imipramine and clomipramine and their demethylated metabolites desipramine and desmethylclomipramine were determined during the treatment. The ratio between the plasma level of the parent drug and its demethylated metabolite was on average twice as high during intramuscular as during oral treatment.

Administration, Oral↗
PubMed1977

Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats.

Imipramine and clomipramine were administered to rats by the oral and intramuscular routes as single and multiple doses. The concentrations of both drugs and their active demethylated metabolites desipramine and desmethylclomipramine were measured in blood plasma, blood cells and brain. The concentrations of the metabolites were higher and the concentrations of the parent substances lower after oral than after parenteral administration, both in blood and in brain. In brain imipramine, despiramine and clomipramine during continuous treatment exceeded their plasma concentrations by six to ten times. The corresponding figure for desmethylclomipramine was 1-7. The extent of accumulation of the investigated substances in the brain was independent of the route of administration.

Administration, Oral↗
PubMed1977

[Treatment of childhood humeral fractures by wire fixation].

Out of 526 upper limb fractures treated in the Pediatric Surgery Department of the Péterfy Sándor Hospital between 1970-1975, 63 patients were operated on. (11.9%). Fractures in childhood are generally treated by closed methods because healing of the growing bone is favourable. If it is reasonable, fractures of the forearm bones are successfully treated by means of intramedullary wire fixation, fractures of the elbow by means of transfixation. No septic complication occured following operation. Growth disturbancies were not observed in the affected bones after the operative intervention in the course of 1 to 5 years. On this ground the author recommends the adaptational "minimal" osteosynthesis in the treatment of fractures in infancy, if closed methods do not promise optimal results.

Accidents, Traffic↗