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Biomedical subjects

A N Nasedkin

Publications and source records attributed to A N Nasedkin.

15 recordsLinked to original sources
PubMed2001

[Photodynamic therapy of recurrent and residual oropharyngeal and laryngeal tumors].

Photodynamic therapy (PDT) was given to 61 patients with recurrent cancer of the tongue, oral mucosa, lower lip, oro- and nasopharynx, larynx. Photosensitizers photogem and photosens of Russian produce were employed. The radiation was given twice with the interval 24 and 48 hours, the exposure to light 3 to 30 min. The impact was external, through the instrumental canal of the fibroscope, by intracavitary and interstitial techniques. The response was assessed within 4-6 weeks after the PDT course. The effect was observed in 95.1% patients. Its duration ranged from 4 months to 5 years. Complete resorption of the tumor was achieved in 57.4%. The treatment failed in 4.9% patients.

Aged↗
PubMed2001

[Updated laser technologies in otorhinolaryngology].

Clinical trials have been conducted of a new therapeutic semiconductor laser from the Mustang series which generates laser radiation in red light range (0.63-0.65 mcm) in impulse mode. Laser therapy was given to 75 patients with different ENT diseases with good effect. A surgical laser unit CTH-10 (YAG-Ho laser, 2.09 mcm) has undergone pilot tests with good results in 12 patients with pain maxillofacial syndromes. Photodynamic therapy was used in upper respiratory tract cancer in 27 patients, the results are analysed.

Humans↗
PubMed1993

[The experimental validation of the clinical use of new surgical lasers].

A comparative evaluation has been carried out between the effects of surgical CO2-laser (lambda = 10.6 mcm) and lasers previously unused in medicine: Yag-erbium (lambda = 2.94 mcm) and YAG-erbium-in-glass lasers on biological tissue. The cutting properties of the lasers, nature of their effect on tissue and the period of healing of laser injury were studied morphologically. Effects of radiation on the energetic, biosynthetic and proliferative processes in the liver tissue, as well as the activity of transamination enzymes have been investigated. It has been shown that laser radiation of lambda = 1.54 and lambda = 2.94 mcm can destroy biological tissue with minimum inflammatory reaction as compared to CO2-laser. It has been ascertained that better marked changes in bioenergetics, aminotransferase activity, RNA and DNA contents are observed under the influence of CO2 and YAG-erbium lasers. Exposure of liver to YAG-erbium-in-glass laser radiation produced minimum changes in cells of the tissue contiguous to the injury. Thus, under its influence the majority of the investigated indices either changed insignificantly or improved. This might account for a positive effect of this laser on the dynamics and quality of the injury healing. The experimental studies gave basis for creation of working models of laser devices (lambda = 1.54 mcm) which are undergoing successful clinical trials at present.

Animals↗
PubMedDate not supplied

[Surgical treatment of children with cicatricial stenoses of the larynx and trachea].

The present authors recommend a modification of Ivanov's method suggested by their treatment of 41 children, aged 4 to 15 years; 12 patients suffered from stenosis and 29 patients from atresia of the larynx and trachea, which resulted from surgical intervention required by the complications of extended nasotracheal intubation and subsequent tracheotomy. The modified procedure is as follows. In order to enlarge the laryngeal or tracheal lumen, skin is cut and one or two triangle-shaped skin flaps are dissected; their tops are sutured to the anterior wall of the above organs cut along the median line. In order to distend the larynx, redressment of the cricoid cartilage is needed. He-Ne laser irradiation (of 20 mW/cm2 with a wavelength of 632.8 nm) and collagenase and elastase enzymes stimulate repair and prevent secondary cicatrization of post-operative wound. The lumen is formed using a T-shaped silicon tube. Out of 4 patients followed-up during the last 5 years, 21 were decannulated, 12 developed good laryngotracheostoma, 5 of which required suture of wound. Only 8 patients who had laryngotracheostoma needed surgical intervention due to repeated cicatrization. In 4 of these patients, allogenic cartilage was used for support, and polymer paste Polytel was applied to eliminate laryngeal, tracheal or esophageal fistulas.

Adolescent↗
PubMedDate not supplied

[Laryngotracheoplasty with a bone-muscle transplant in children].

Laryngotracheoplasty using an osteomuscular graft in modification of the authors was performed in 35 patients aged 5-15. The children suffered from severe cicatricial laryngostenoses and laryngeal-tracheal atresias. Postoperative results are available for 22 children. Decannulation was performed in all the children. They have closed tracheostoma and free breathing. 13 children need phonopedic aid, 5 patients need repeat change of the protector, 2 children underwent resurgery, 2 patients are to undergo reoperation. Further studies should be directed to search for new modalities to prevent granulations growth, to speed up postoperative epithelialization.

Adolescent↗