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Biomedical subjects

A N Kokosov

Publications and source records attributed to A N Kokosov.

At least 19 recordsLinked to original sources
PubMed2004

Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease.

The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).

Case-Control Studies↗
PubMed2003

[Stage I-III pulmonary sarcoidosis complicated by nephrogenic (vasopressin-resistant) form of diabetes insipidus].

Literature data and original experience of the authors with 6890 cases of respiratory sarcoidosis (stage I-III) suggest that diabetes ipsipidus in respiratory sarcoidosis (RS) can present as hypothalamic-hypophysial form (observed at the stage I-II by physicians since 1935) and a new form--nephrogenic (vasopressin-resistant) at stage II of pulmonary sarcoidosis. The latter form is little known. It was found that in stage III sarcoidosis patients who have severe fibrosis of the lungs and a long history of corticosteroid hormone treatment the nephrogenic form of the pathogenesis is caused by defects in calcium metabolism leading to nephrocalcinosis with low sensitivity of renal tubular receptors to ADH. Adiurecrine treatment is unefficient. It is recommended to use chlorpropamide which raises sensitivity of the tubules to ADH.

Diabetes Insipidus↗
PubMed2003

[Post-tuberculous fibrous mediastinitis: a report of a case followed-up for many years].

The paper reports a rare case of fibrosing mediastinitis of posttuberculous genesis caused by infection with Mycobacterium bovis. Such cases are not available in the literature so far. The patient was observed from 1956 to 2001. Bovine tubercle bacilla affect mediastinal lymph nodes which undergo fibrosis resulting in stenosis of the trachea, major bronchi, esophagus. Narrowing of the chest duct leads to formation of severe recurrent transudate in the left pleural cavity (for 3 years 70 pleural punctures were made with removal of a total of 22 l of fluid).

Fibrosis↗
PubMed2003

[Causes of lethal outcomes in presenile and senile patients treated in pulmonological hospital].

Causes of lethal outcomes were analysed for 46 patients (mean age 76.76 years, 39 males, or 84.78%, and 7 females, or 15.22%) why died of respiratory diseases when treated in War Veterans Hospital of St-Petersburg. Necropsies registered the following causes of death: chronic obstructive pulmonary disease (COPD) (32 deaths, 69.57%), cardiovascular diseases (17 deaths, 36.96%), cancer (14 deaths, 30.44%). Lethal outcomes were most frequent at the age of 71 to 80 years (52.17%). COPD was present in 43 of 46 of the deceased (93.48%). The most frequent direct causes of lethal outcomes in elderly patients with COPD were isolated pulmonary-cardiac insufficiency and combination of this insufficiency with pneumonia which is as an aggravating factor and determines the outcome of the basic disease.

Aged↗
PubMed2001

[Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors].

AIM: To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development. MATERIAL AND METHODS: 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis. RESULTS: An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD. CONCLUSION: Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.

Adult↗
PubMed1997

[A functional-morphological study of the mucociliary system at stages in the disease in patients with chronic bronchitis].

Combined morpho-functional study of the mucociliary system in patients with chronic bronchitis at different stages of its development was made. Regional mucociliary clearance was evaluated by dynamic aerosol scintigraphy and electron microscopy. Radiography of bronchial biopsies was performed, rheological properties of bronchial content were also determined. Special characteristics of mucociliary main chains were established at each stage of chronic bronchitis development as well as depending on the type of bronchitis, bronchial tree level and phase of the disease. New hypothesis on chronic obstructive bronchitis genesis was substantiated.

Adolescent↗