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Biomedical subjects

A N Gupta

Publications and source records attributed to A N Gupta.

At least 37 records · Page 2Linked to original sources
PubMed1984

Egg shell formation by vitelline globules or by uterus. An introspection.

The question of the formation of the egg shell has attracted attention of most of the helminthologists and several different views have been expressed from time to time. The most agreed view which held the vitelline globules responsible for forming precursors of the shell membrane, has now become questionable in view of the fact that there are trematodes in which neither Mehlis' gland nor vitelline glands are present. The authors have demonstrated histochemically and histologically that the proximal part of the uterus has the necessary potentialities to form the egg shell membrane.

Animals↗
PubMed1982

Pregnancy specific proteins: suppression of in vitro blastogenic response to mitogen by these proteins.

Immunosuppressive properties of human chorionic gonadotropin (HCG), pregnancy specific B1-glycoprotein (SP-1), human alpha foetoprotein (AFP), and human placental lactogen (HPL) in mitogen-stimulated lymphocyte transformation were studied. A pregnancy serum containing high serum levels of these specific proteins was prepared from a number of pregnancy sera. The inhibitory effect of pregnancy sera on lymphocyte response to mitogen was examined after sequential removal of each of the proteins from the pregnancy serum by affinity chromatography. Greatest decrease in the suppression was observed when human chorionic gonadotropin (HCG) alone or human chorionic gonadotropin in combination with all other three specific proteins was removed from the pregnancy serum. Pregnancy specific B1-glycoprotein (SP-1) also significantly decreased the inhibitory effect of pregnancy serum. But the other two specific proteins (AFP and HPL) had minimal effect on the decrease an immunosuppression by pregnancy serum. However, even after removal of all the four pregnancy specific proteins from the pregnancy serum, complete return to normal values for lymphocyte transformation by mitogen was not observed, which indicates the presence of some other suppressive factor(s) in the pregnancy serum.

Animals↗
PubMed1982

Effect of seminal plasma and its fractions on in vitro blastogenic response to mitogen.

Five fractions of human seminal plasma were isolated on Sephadex G-100 column. The in vitro effect of whole human seminal plasma and its fractions on the lymphocyte transformation induced by phytomitogen was studied. A significant inhibition of lymphocyte response to mitogen was observed with whole seminal plasma fractions I and III at a concentration of 100-200 micrograms/ml. However fraction II stimulates the in vitro human lymphocyte transformation induced by phytomitogen at a concentration of 200 micrograms/ml. Maximum amount of inhibition by whole seminal plasma and its fractions I and III was achieved by preexposure of lymphocytes to these antigens. Pre-exposure of lymphocytes to these antigens, followed by washing, does not result in suppression of lymphocyte response to mitogen. These observations suggest that the antigens of the whole seminal plasma or of fractions I, III, and II act by simple competition with mitogen for the receptor sites on the lymphocyte membrane. Therefore, the human seminal plasma may play an immunoregulatory role against the auto- or isosensitization towards spermatozoal antigens.

Cells, Cultured↗
PubMed1981

Placenta previa and previous cesarean section.

In a retrospective analysis over the six year period, January, 1973 to December, 1978, the incidence of placenta previa in cases with previous cesarean section (C.S.) was found to be 3.9 per cent as compared to an overall incidence of 1.9 per cent (p less than 0.01). The risk of placenta previa was greater in the pregnancy immediately following the cesarean section. The incidence of a morbidy adherent placenta was also significantly higher in these cases.

Cesarean Section↗