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Biomedical subjects

A N Britov

Publications and source records attributed to A N Britov.

At least 19 recordsLinked to original sources
PubMed2006

[Relationships between arterial hypertension, metabolic disturbances and uric acid nephropathy].

AIM: To study effects of uric acid disbolism in combination with other metabolic disturbances on prevalence and clinical symptoms of arterial hypertension; contribution of uric acid nephropathy to its development. MATERIAL AND METHODS: A cohort of 243 representatives from a general population (107 males, 136 females, age 19-59 years) was studied in 1986 and 15 years later. At the beginning and end of the trial the participants were examined for arterial hypertension, microalbuminuria, uric acid nephropathy, blood biochemical tests were made. RESULTS: For 15-year follow-up prevalence of arterial hypertension doubled, incidence of hyperuricemia and hyperuricosuria, hypertriglyceridemia increased considerably. The number of hypertensive subjects was maximal in the group with the greatest number of signs of uric acid nephropathy. CONCLUSION: The population studied exhibited increasing frequency of some risk factors, especially of uric acid metabolism, contributing to formation of arterial hypertension.

Adult↗
PubMed2003

[New guidelines of the Joint National Committee (USA) on Prevention, Diagnosis and Management of Hypertension. From JNC VI to JNC VII].

Need for update of guidelines of the Joint National Committee (USA) on Prevention, Diagnosis and Management of Hypertension was based on necessity to adopt changes based on results of recent studies as well as creation of more simple and convenient variant for practical physicians. Compared with JNC VI most important changes concerned classification of blood pressure (BP) levels and approaches to drug therapy. New category "prehypertension" was introduced and 2 stages of hypertension distinguished: stage I - systolic BP 140-159 mm Hg or diastolic 90-99 mm Hg, stage II - systolic BP 160 mm Hg or higher, diastolic BP 100 mm Hg or higher. Diuretics were recommended as drugs of first choice and wider use of drug combinations encouraged. Some statements of JNC VII report have been criticized by some hypertension authorities.

Antihypertensive Agents↗
PubMed2002

[Control of arterial hypertension in stroke prevention].

According to epidemiological surveys arterial hypertension increases the risk of death of coronary heart disease 3-hold, of hemorrhagic and ischemic strokes--6-fold. Treatment of arterial hypertension leads to a significant fall in the risk of strokes and ischemic heart disease. The PROGRESS trial demonstrates that antihypertensive therapy of patients with the history of acute cerebral circulation disorder with ACE inhibitor perindopril is effective in secondary prophylaxis in such patients.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed2002

[Monitoring arterial hypertension in workers in professions exposed to vibration hazards (results of a 15-year study)].

AIM: To follow up for 15 years prevalence of arterial hypertension (AH) in workers exposed to vibration, to study AH course and possible correction in long-term vibration exposure. MATERIAL AND METHODS: The survey covered 1232 males aged 25-59 years exposed to vibration at their working places for 1 to 30 years (test group) and 1163 males matched for age but not exposed to vibration (control group). Active primary and secondary prevention of AH and annual population control for 10 years were performed in the test group. The control group was followed up outpatiently without active intervention. Final screening was conducted 5 years after completion of the program of AH prophylaxis. RESULTS: Among workers exposed to vibration AH prevalence was similar to that in the controls and tended to reduction in the process of preventive treatment. However, after the end of prophylactic measures AH incidence rate returned to the baseline level. In workers at risk of vibration aftereffects conversion of normal arterial pressure to hypertension was observed more frequently than in unexposed patients. This requires active prophylactic intervention. CONCLUSION: Long-term exposure to moderate and high frequency vibration is an AH risk factor. Incidence rate of AH increases with longer exposure to vibration. Compared to controls, aged workers exposed to vibration have AH much more frequently.

Adult↗
PubMed2002

[Dynamics of rates of fatal and nonfatal complications of hypertension in a population of workers subjected to occupational vibration (15-year follow-up)].

Prospective monitoring of fatal and nonfatal myocardial infarctions and strokes was carried out in a population of workers with professional exposure to vibration. Duration of monitoring was 15 years. In the end of this period implementation of a program of preventive intervention was associated with lowering of rates of cerebral and coronary events (3.0 vs. 5.2% among nonparticipants in this program). In 5 years after cessation of the program an increase of risk of cardiovascular complications especially that of strokes occurred. Changes of rates of events in a group of workers not subjected to special intervention were less pronounced. Negative dynamics of event rates in the group of active prevention could be attributed to continuing action of unfavorable occupational factor.

Adult↗
PubMed2001

[Hormone replacement therapy in women with arterial hypertension in peri- and postmenopause: hemodynamic effects].

AIM: To study hemodynamic effects of replacement hormone therapy (RHT) with trisecvens, beta-blocker betaksolol and their combination in perimenopausal and menopausal women with hypertension. MATERIAL AND METHODS: The study was made of 60 menopausal women aged 45-60 with mild and moderate arterial hypertension (AH). The women had no contraindications to either RHT or beta-blockers. They were randomized into three groups: group 1 received trisekvens, group 2--trisekvens plus betaksolol in a dose 10-20 mg/day, group 3--betaksolol. Arterial pressure (AP) and heart rate (HR) were measured before the treatment, in one month and each three months for a year. ECG and echo-CG were registered before treatment and each 3 months of the therapy. AP monitoring covered 50% of the patients of each group before the treatment and after 1 and 3 months of it. The data were analysed according to SAS system. RESULTS: Group 1 patients showed no significant changes in AP and HR. Group 2 and 3 patients' AP lowered, in group 2 the fall of systolic AP being more pronounced. 12-month therapy brought about a 10.3% decrease in left ventricular myocardial mass index in group 2. CONCLUSION: RHT with trisekvens in combination with beta-blocker in long-term use potentiates the effect on systolic AP and reduced hypertrophy of the left ventricle. RHT does not produce a significant effect on AP in women with AH recorded before the menopause.

Adrenergic beta-Antagonists↗
PubMed1999

[Betaxolol treatment of hypertension in postmenopausal women].

AIM: The study of hypotensive efficacy of high-cardioselective beta-blocker betaxolol, its effects on lipid and carbohydrate metabolism, menopausal syndrome in females with mild and moderate arterial hypertension. MATERIALS AND METHODS: 20 postmenopausal 45-59-year-old women entered the trial of betaxolol. They had diastolic blood pressure 90-114 mm Hg. Beta-blockers were not contraindicated. Arterial pressure, heart rate, body mass, blood lipid spectrum, glucose and insulin levels were evaluated before the treatment, 1, 3 and 6 months after it. RESULTS: Betaxolol safely and effectively lowered blood pressure. Blood lipid spectrum remained unchanged. A transitory rise in fasting insulin levels did not worsen glucose tolerance despite a small gain in body mass. Menopausal syndrome relieved due to good effect of betaxolol on vasomotor disorders. CONCLUSION: Betaxolol has a good hypotensive effect in the absence of adverse effects on lipid and carbohydrate metabolism. A reduction of menopausal syndrome was also achieved.

Adrenergic beta-Antagonists↗
PubMed1994

Nonlinear relationship between erythrocyte sodium-lithium countertransport and blood pressure in man.

A relationship between erythrocyte Na+/Li(+)-countertransport activity and blood pressure was studied in a randomly selected sample (95 subjects) with full range of blood pressure, from a representative group of inhabitants of one of Moscow's districts. The mean rate of erythrocyte Na+/Li(+)- countertransport activity was higher (p < 0.01 or less) in the groups of subjects with both borderline (BH) and moderate essential hypertension (EH) as compared with the group of normotensives (NT). A positive correlation was found between the erythrocyte Na+/Li(+)- countertransport rate and age and body weight in the entire selected group. The total contribution of these confounding parameters is responsible for 20.4% of the interindividual variability of the Na+/Li(+)- countertransport activity. The individual Na+/Li(+)- countertransport values remained unchanged during at least 2 years of follow-up. A nonlinear relationship between erythrocyte Na+/Li(+)- countertransport activity and blood pressure was established in the entire group. No significant association between blood pressure and Na+/Li(+)- countertransport was seen at high and low values of these two parameters. A pronounced change in the erythrocyte Na+/Li(+)- countertransport values occurred within a narrow borderline blood pressure range.

Adult↗
PubMed1993

[The relation of physical work capacity to the arterial pressure level and risk factors for arterial hypertension].

A multivariate regression analysis including muscular performance, arterial pressure, age, heart rate, body-weight index permitted identification of independent relations between pressure and muscular performance. The latter accounts for 3% variability in initial systolic pressure in females and for 3% variability in males under physical loading. Initial systolic pressure accounts for 5% variability of muscular performance in females. The dependence between muscular performance and diastolic pressure is indirect, noticeable only in physical load with the help of double product.

Adult↗