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Biomedical subjects

A N Brest

Publications and source records attributed to A N Brest.

At least 55 records · Page 3Linked to original sources
PubMed1975

Heart failure in acute myocardial infarction.

In recent years, our understnading of heart failure complicating acute myocardial infarction has expanded considerably. Although it is not always possible to control cardiac decompensation in this situation, rational therapy has evolved with the improved recognition of the hemodynamic alterations in heart failure and the factors contributing to ventricular performance. Furthermore, a more secure physiologic basis now exists for the early identification of such patients and the development of additional therapeutic techniques.

Heart Failure↗
PubMed1969

Creatinine clearance in renal disease. A reappraisal.

To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal endogenous creatinine clearance masked a definite but mild decrease of glomerular filtration rate in 42% of the patients and a moderate decrease of glomerular filtration rate in 23%. This indicates that with declining glomerular filtration rates the endogenous creatinine clearance progressively overestimates actual glomerular filtration rates. Hence a single determination of creatinine clearance can be misleading as a screening measurement of glomerular filtration rate.

Adult↗