Distance-weighted backprojection: a SPECT reconstruction technique.
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Humans↗
Biomedical subjects
A N Bice
Publications and source records attributed to A N Bice.
Simplified detection system for neuroreceptor studies in the human brain.
A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.
Binding, Competitive↗
Estimation of bladder wall absorbed dose.
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Fluorine↗
Absorbed fractions for dose calculations of neuroreceptor PET studies.
A simple Monte Carlo program was constructed for the purpose of calculating absorbed fractions of relevance to neurologic positron-emission-tomography studies. The caudate, putamen, and cerebellum regions of the brain were mathematically modeled to serve as source regions for the absorbed-fraction calculations for positron-annihilation photons. The target organs were the caudate, putamen, cerebellum, brain, spine portion in the head, skull, and head. Absorbed fractions were also calculated for a uniform ring source which encircled the head phantom.
Absorption↗
A simple instrument for biochemical studies of the living human brain.
A simple, relatively inexpensive radiation detection system was developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high-efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]-carfentanil, a high-affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist exemplifies the use of this system for estimating different degrees of receptor binding of drugs in the human brain. The instrument has also been used for measurement of the transport into the brain of other positron-emitting radiotracers, such as large neutral amino acids.
Adult↗