[Kinetics of blood leukocytes in mice with alloxan diabetes].
Explore the source record for details and available documents.
Alloxan↗
Biomedical subjects
A N Baĭkov
Publications and source records attributed to A N Baĭkov.
[Biventricular auxiliary system for restoration of cardiac activity].
Thirty experiments were conducted on calves for hemodynamic study of mechanical aid to the heart (biventricular bypass by two artificial ++"Module"+ ventricles of the heart) in acute cardiac failure. The cavities of the heart were cannulated with a special perforating device which, when necessary, is an obturator of the main line. Analysis of the hemodynamic values showed a sufficiently high efficacy of biventricular shunting in acute cardiac failure. The device for draining the heart cavities has advantages over the traditional main lines, in particular the number of complications from bleeding and air embolism reduces with its use.
Acute Disease↗
[Electric stimulation of skeletal muscles as the optimal method of left-ventricular bypass].
Experiments were performed on 15 mongrel dogs to evaluate the influence of electrostimulated contractions of the hind limb and abdominal skeletal muscles on the efficacy of assisted circulation (AC). The influence of massage of the abdomen on AC efficacy was studied in 10 experiments. In electrostimulation of the hind limb muscles the drainage along the femoral vein, measured by the direct method, increased threefold: from 58 +/- 9 to 162 +/- 7 ml/min under conditions of an intact heart and from 5.8 +/- 0.8 to 15 +/- 1.2 ml/min in cardiac insufficiency. The efficacy of AC by the method of left-ventricular bypass by means of the Module artificial heart ventricle (AHV) increased through the flow of blood to the heart, which was manifested by greater AHV performance with rise of systolic and diastolic pressure to 7-8 mm Hg. In cardiovascular insufficiency the influence of electrostimulation on AC efficacy was weaker, the systolic and diastolic pressure increased only by 2-4 mm Hg, in massage of the abdomen both indices increased by 8-10 mm Hg.
Abdominal Muscles↗
[Clinical use of artificial heart ventricles].
The article discusses the results of applying for the first time Soviet-made "Modul" and "Yasen" artificial ventricles of the heart (AVH) in a left ventricular bypass regimen in patients with refractory cardiac insufficiency. Improvement of AVH design and rational tactics of attendant drug therapy allowed the period of the safe application of the AVH in the organism to be increased to more than 8 days.
Adult↗
[Effects of ultra-dispersed piezoceramics Pb powders on staff's health status].
The ultradispersed piezoceramic powder containing lead oxides, zirconium, titanium, bismuth, cadmium, manganese, strontium, and chromium was tested for its effect on the health status of the staff serving pilot industrial units producing the powder. There was a significant increase in the incidence of digestive disease, a tendency for respiratory and osteomuscular diseases to increase. It is concluded that it is necessary to use individual means of the protection and prophylaxis of the observed diseases.
Catchment Area, Health↗
[Choosing the structure of the control system for an external counterpulsation complex].
The paper is concerned with the principles of choosing the structure of the external counterpulsation control on an a.c. hydrodrive. An autonomous control mode and the control principles using a specialized microprocessor as well as computer-aided feedback control have been investigated.
Counterpulsation↗
[Methods of draining the heart cavity for assisted circulation].
Explore the source record for details and available documents.
Assisted Circulation↗
[Status of nucleic acid and total protein synthesis in hematopoietic organs in mice with alloxan diabetes].
Rates of 3H-thymidine, 3H-uridine and 14C-glycine incorporation in nucleic acids and total proteins were studied in cells of bone marrow, spleen, thymus and ileocecal lymph nodes tissues of BALB/c mice with subacute alloxan diabetes (content of blood sugar was higher than 14 mmol/l). Synthesis of DNA, RNA and protein was not considerably inhibited in the thymus tissue of the impaired animals which may correlate with pronounced dysfunction of cytotoxic T lymphocytes typical for the disease.
Alloxan↗
[Metabolism of neutral lipids in hemopoietic organs and in the liver of mice with alloxan diabetes].
The metabolism of neutral lipids (free and ester-bound cholesterols, mono-, di- and triacylglycerides) was greatly impaired in liver, spleen, thymus tissues and ileocecal lymph nodes of BALB/c mice with subacute alloxan diabetes (content of sugar in blood was no less than 14 mmol/l) as shown by 3H-acetate and 14C-palmitate incorporation into the corresponding lipid fractions. The rate of neutral lipid turnover was specifically decreased in all the tissues studied. However, a considerable accumulation of these lipid fractions was found in thymus tissue. Incorporation of labelled palmitate into triacylglycerides was increased in the spleen but without obesity of the organ.
Alloxan↗
[Noninvasive assisted blood circulation].
The experience of the use of noninvasive assisted circulation in patients with cardiac pathology is summarized. It has been demonstrated that rhythmic pneumo-compression of the lower extremities, abdominal compression, muscular electrical stimulation of the lower extremities and the abdomen have a pronounced effect on circulation compartments with low pressure. All the above pre-determines the role of these techniques in the management of cardiac failure and in intensive care.
Abdomen↗
[Status of nucleoprotein synthesis in hematopoietic organs in mice with primary hypothyroidism].
A rate of incorporation of 3H-thymidine, 3H-uridine and 14C-glycine into the nucleoproteins of bone marrow, spleen, thymus and ileocecal lymph nodes was studied in BALB/c mice with hypothyrosis developed after administration of 1% KClO4 within a month. Distinct hypoplasia of bone marrow and spleen was found in the experimental animals; the synthesis of nucleoproteins was most impaired in bone marrow. The dependence of hemopoietic tissues on thyroid hormones was decreased as follows: bone marrow > spleen > thymus > lymph node. After subcutaneous administration of triiodothyronine (T3) in a dose of 50 mg/kg daily within 3 days of synthesis of nucleoproteins was considerably stimulated and the amount of cells was increased in bone marrow and spleen. Less distinct stimulating effect of T3 was observed in the thymus and lymph nodes of these animals.
Animals↗
[Abdominal compression as a method of resuscitation and assisted circulation].
Experiments on animals have been carried out to investigate the hemodynamic changes during manual abdominal compression (AC) under conditions of heart fibrillation and acute heart failure. The possibility to increase the efficacy of left ventricular bypass (LVB) has been studied. Manual AC enhanced the pressure and blood flow in low-pressure compartments and increased aortic systolic and diastolic pressure. It has been also noted that LVB efficacy was increased in simultaneous assisted perfusion and abdominal compression. The first clinical data confirm the experimental findings.
Abdomen↗
[Cryogenic effect on renal tissue and condition of intrarenal hemodynamics].
The paper presents experimental evidence on morphologic changes in intact kidney, tissue temperature, renal blood supply and glomerular filtration in response to freezing. Cryogenic effects manifested as necrotic and dystrophic processes. Damage to the tubular and glomerular cells can be corrected. Blood flow in the kidney was not interrupted but was directed through the bypass routes.
Animals↗
[The effect of freezing the kidney in the terminal stage of hydronephrosis on its parenchymal function, arterial pressure regulation and erythropoiesis].
The authors studied morphological changes in renal tissue in terminal hydronephrosis and in exposure of freezing, regulation of arterial pressure and erythropoiesis in cryogenic effects on hydronephrotic kidney in experiment. Reparative changes in the parenchyma appear on day 30 after freezing, systemic arterial pressure and bone marrow erythropoietic activity returned to normal. Freezing is thought more physiological compared to nephrectomy in respect to prevention of nephrogenic hypertension and anemia.
Animals↗
[Study of phospholipid synthesis in liver of mice with alloxan diabetes].
The essential decrease of the rate of turnover of phosphatidic acids (PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM) and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male mice of BALB/c strain with subacute alloxan diabetes (glucose concentration in the blood was not less than 14 mmol/l) during examination of phospholipid metabolism in the liver by the rate of 3H-acetate and 14C-palmitate incorporation into corresponding chromatographic phospholipid fractions. On the contrary, turnover of phosphatidilcholine (PC) significantly increased. The of main structural phospholipid components of hepatocyte cellular membranes--PEA and PC--were found to be decreased by 41 and 32%, respectively. LPGP and PA levels decreased to a lesser extent. The level of PGP, SM, phosphatidylinositol and LPG did not differ from the control level.
Alloxan↗