Biomedical subjects
A Munro
Publications and source records attributed to A Munro.
Improving communication between hospitals and family physicians.
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Thrombotic risks of staging laparotomy with splenectomy in Hodgkin's disease.
No significant excess of deep vein thrombosis (DVT) as measured by the 125I-labelled fibrinogen method was observed in patients having staging laparotomy and splenectomy for Hodgkin's disease (HD) compared with patients having elective cholecystectomy under highly standardized surgical conditions. Patients who did have DVT all had splenic involvement with HD. There was no correlation between the post-splenectomy thrombocytosis and the occurrence of DVT. Patients with non-Hodgkin's lymphoma (NHL) and splenomegaly had a high incidence of DVT after splenectomy.
Focus: the wrong doctors: selection or training at fault?
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Monosymptomatic psychoses which progress to schizophrenia.
Two cases of paranoid schizophrenia are described in which an olfactory delusion was the predominant symptom at some stage in the illnesses. A distinction is drawn between these cases, and cases of Olfactory Reference Syndrome, in which the olfactory delusion is the main feature and schizophrenic decompensation does not occur. An argument is advanced that the Olfactory Reference Syndrome (ORS) is one subtype of Monosymptomatic Hypochondriacal Psychosis (MHP) and reference is made to evidence suggesting that pimozide may be a specific and effective treatment in the various presentations of MHP.
An aid to low restorative anastomosis of the rectum.
A new suture-holding clamp is described which simplifies single-layer colorectal anastomosis performed deep in the pelvis.
The role of MHC gene products in the development of the T-cell repertoire.
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Proliferative response of lymphocytes of normal individuals to wheat proteins (gliadins).
Preparations of gliadin, extracted from wheat gluten, were shown to stimulate a proliferative response by lymphocytes of normal donors. Not all donors responded to gliadin. In all but one case responder or non-responder status remained consistent on retesting. There was no association of ability to respond with HLA A or B type.
Monosymptomatic hypochondriacal psychosis.
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Vascular correlates of circular type manic-depressive disorder.
An ambulant patient with a regular series of mood changes constantly varying between retarded depression and hypomania on a 32- to 36-day cycle was studied for 39 weeks. The patient completed a daily self-assessment of the 11-point Dorland mood scale each evening. This scale encompasses a range of moods varying from depression through euthymia to mania. Weekly recordings each lasting 65 min were made of resting heart rate, 14 parameters derived from electrical impedance plethysmography of the head together with arterial blood pressures before and after each recording. Results were correlated with the changing mood scores. Time series analysis of the mood scores yielded a recurrent mood cycle of 35 days unchanged by such drug treatments as had been prescribed by the psychiatrist. The mood score correlated positively with the impedance amplitude, inflow angle, and transit times, and negatively with percent rise time, heart rate, and blood pressures. Amplitudes, rise times, and CT2 were independent of heart rate and blood pressures and hence probably related more closely to cerebral blood flow.
Psychological evaluation in cases of self-poisoning.
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Operative intubation in the treatment of complicated small bowel obstruction.
Intestinal intubation carried out at laparotomy for complicated small bowel obstruction is not yet a generally accepted technique. Experience in 32 patients has shown that it is safe and effective. The procedure was initially described in North America for use in recurrent adhesive small intestinal obstruction but the indications have been extended and it has proved of value in other difficult situations. A technique for intubation is described and the results obtained in various clinical situations are given.
Anti-digoxin antibody incorporation into liposomes: a potential therapy for digoxin toxicity [proceedings].
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The major histocompatibility system and the immune response.
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Two cases of delusions of worm infestation.
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Monosymptomatic hypochondriacal psychoses: a diagnostic entity which may respond to pimozide.
Monosymptomatic hypochondriacal psychoses are akin to paranoia. Although presenting with a variety of delusional complaints in individual cases, the condition appears to represent a relatively dis crete diagnostic entity. It is less rare than usually thought, but those afflicted frequently to to the physical specialties, whose treatment does not benefit them. It is important to recognize the illness, since there is tentative evidence that it may respond to treatment with pimozide.
Monosymptomatic hypochondriacal psychosis manifesting as delusions of parasitosis. A description of four cases successfuly treated with pimozide.
A recent article in the Archives described the severe problems encountered in trying to treat patients with delusions of parasitosis. The present article describes four such cases, which fall into the larger category of monosymptomatic hypochondriacal psychoses, conditions that appear to be related to the paranoid disorders. Evidence is accumulating that such cases may respond very specifically to treatment with pimozide, a relatively new psychotropic medication. This drug keeps the symptoms in remission but does not effect a cure; nevertheless, it may represent a highly important advance in therapy in a condition traditionally regarded as virtually untreatable.
Colectomy and ileorectal anastomosis for colitis: report on a personal series, with a critical review.
In a consecutive series of 86 patients who required total colectomy for inflammatory bowel disease, 36 (43 per cent) had an ileorectal anastomosis. On review between 1 and 18 years after the operation, there were 25 patients who retained the anastomosis, all of whom were in good general health. Details of their clinical and sigmoidoscopic assessment and the histological grading of rectal biopsies are given. The results are compared with other published reports in a critical review of the present standing of ileorectal anastomosis.