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Biomedical subjects

A Morin

Publications and source records attributed to A Morin.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Linear growth in children with congenital hypothyroidism detected by neonatal screening and treated early: a longitudinal study.

We performed a longitudinal study of a cohort of 74 children with congenital hypothyroidism (CH) detected by neonatal screening (Buenos Aires Province, Argentina) up to the age of 3 years old, in order to study linear growth and the relationship with the severity of CH at diagnosis. The mean age at diagnosis and the start of the treatment was 16.9 +/- 5.2 days. The patients were divided into group 1--severe CH (pretreatment T4 level <4 microg/dl) (n = 47)--and group 2--less severe CH (pretreatment T4 level > or = 4 microg/dl) (n = 27). Patients with CH treated early showed a sexually dimorphic pattern of growth: girls tended to be longer than boys at all ages. Boys showed some delay of growth during the first year. No difference was found in linear growth between the two groups (more/less severe CH). Height was normal in both sexes at the age of 3 years old.

Child Development↗
PubMedDate not supplied

A recent overview on in vitro and in vivo immunological activities of methisoprinol.

Methisoprinol (Isoprinosine), a purine derivative, has been shown to exert a number of immunopharmacological effects, both in vitro and in vivo, in animal and human studies. The agent, somehow mimicking the effects of thymic factors, induces the appearance of phenotypic markers of differentiation on immature precursor T cells; enhances the proliferative response of murine and human lymphocytes to mitogens or antigens, augments helper or suppressor T cell functions and increases the production of lymphotoxin a lymphokine. It has also been shown that this drug can potentiate the effects of macrophage activating factor to stimulate macrophage, and of interferon to protect mice against experimental viral and tumor challenges. In humans, beneficial results have been reported from clinical trials testing the effects of methisoprinol in a variety of diseases including subacute sclerosing panencephalitis (SSPE), acute viral encephalitis, recurrent mucocutaneous infections due to type I and II Herpes viruses as well as in immune restoration of cancer patients with immunodepression following radiotherapy. The drug is also being studied in immunopathological disorders such as rheumatoid arthritis, systemic lupus erythematosus. Sjogren's disease and type A hepatitis. The large spectrum of effects of methisoprinol on a number of immune parameters, the increasing evidence of its therapeutic value in several pathological conditions and its safety of use qualifies this drug as an interesting immunoregulating agent.

Animals↗
PubMedDate not supplied

[Role of endoplasmic reticulum in the secretion of prolactin (author's transl)].

Thyroliberin (TRH) exerts a biphasic effect on the secretion of prolactin. It involves first a rapid release of a previously formed hormonal pool and then a long term delayed effect on hormone synthesis. Ultrastructural immunocytochemistry has permitted to visualize the prolactin content of the endoplasmic reticulum and to follow the transit of secretory product during TRH induced acute release in GH3 cells and in normal prolactin cells in primary culture. After 30 min, 1 hr of action, TRH induces a decrease in the prolactin content of the endoplasmic reticulum followed after 2 hrs by a reloading of this compartment. These immunocytochemical observations offer a morphological correlate to previous biochemical studies on the biphasic effect of TRH.

Animals↗