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Biomedical subjects

A Moosa

Publications and source records attributed to A Moosa.

At least 91 records · Page 5Linked to original sources

Correlation of single fibre EMG and muscle histochrmistry using an open biopsy recording technique.

Single fibre electromyographic (SFEMG) recordings were carried out during open muscle biopsy. Nine patients were studied, including 5 with Duchenne muscular dystrophy, 2 with spinal muscular atrophy and 1 each with limb-girdle dystrophy and myotonic dystrophy. Correlations were possible between the SFEMG fibre density determinations and histochemical evidence of grouping in some biopsies, particularly involving Type I fibres. This combined technique permits an improved assessment of the functional state of abnormal muscle.

Adolescent↗

Sensory nerve conduction in the spinal muscular atrophies.

Sensory conduction velocities were determined in the sural or median nerve in 16 patients with spinal muscular atrophy of the severe (Werdnig-Hoffmann), intermediate, or mild (Kugelberg-Welander) forms. In all cases there were normal sensory conduction velocities in one of the nerves tested, although sural nerve responses were not obtained in the four youngest patients.

Adolescent↗

Peripheral nerve maturation in English, West Indian and Turkish newborn infants.

The ulnar and posterior tibial conduction velocities were measured in a group of normal full-term English, West Indian and Turkish infants. The English infants had a faster mean ulnar nerve conduction velocity than the West Indian and Turkish infants, but when the sex of the infants was taken into account only the male West Indian infant was found to have slower mean velocities. By three months of age the velocities were similar between the West Indian and English infants. This study emphasises the importance of taking account of the sex of infants in any developmental study.

Age Factors↗

Motor nerve conduction velocity in spinal muscular atrophy of childhood.

The ulnar and posterior tibial conduction velocities were measured in 29 children with spinal muscular atrophy, 14 of whom had the servere form of the disease. The ulnar nerve velocity was slow in 12 of the 14 severely affected infants, but normal or fast in 11 of 14 children less severely affected. The corresponding results for the posterior tibial nerve were slow velocities in 11 of 12 infants in the severe group and normal or fast in all 11 infants less severely affected. The difficulty in distinguishing infantile spinal muscular atrophy from peripheral neuropathy is emphasized.

Charcot-Marie-Tooth Disease↗

Peripheral neuropathy in Leigh's encephalomyelopathy.

An infant with subacute necrotising encephalopathy is described, in whom slow motornerve conduction velocities suggested the presence of peripheral neuropathy. Peripheral nerves are not invariably involved in patients with this disease, but as they are involved in thiamine-deficiency states it is conjectured that the presence or absence of peripheral neuropathy in patients with subacute necrotising encephalopathy may distinguish those with thiamine triphosphate deficiency from those in whom the disease is due to other causes.

Electromyography↗

Quantitative electromyography: a new analogue technique for detecting changes in action potential duration.

An automatic method using an analogue analyser is described for obtaining an index which is based on the mean phase duration of an EMG signal. This method gives similar values for motor unit action potential duration to an alternative digital method of analysis based on the distribution of time intervals between zero crossings of the EMG signal. The analysis has been found to give good discrimination of normal and myopathic EMG signals.

Action Potentials↗