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Biomedical subjects

A Moosa

Publications and source records attributed to A Moosa.

At least 55 records · Page 3Linked to original sources
PubMed1989

Social characteristics and oral health behaviour of families in Riverlea.

Planning of community health programmes requires a comprehensive "community diagnosis" as its basis, taking into account a complex range of health related factors. The family and particularly the mother play a crucial role in oral health. Thus, the social context, the source and extent of health information, as well as their oral health behaviour, can determine the mothers' function in promoting oral health. This study examined the social characteristics and oral health behaviour of families in Riverlea. One hundred and fifty seven mothers were interviewed in their homes using a structured questionnaire. The results reveal a picture where the percentage of 'broken' or single mother families is high. There is overcrowding in the homes combined with a low level of education and employment in mainly non-skilled, low-paid jobs. The utilisation of existing dental services was poor despite the fact that 43 per cent of the families are members of medical aid schemes. Almost one third of the mothers were edentulous. Although cost and other factors were cited as barriers for not 'going to the dentist', most of the respondents have a symptomatic approach to oral health which might be responsible for poor utilisation. The 'lay referral system' for obtaining information was common and teachers played a role in this process. The study identified various factors that adversely affect the process of development of good oral health and related behaviour in the home environment. Schools and supportive community networks as well as outside organizations could be enlisted to take part in the efforts to overcome the barriers identified and improve the situation.

Dental Health Surveys↗
PubMed1988

Evaluation of immunoregulatory cells in Duchenne muscular dystrophy and spinal muscular atrophy among African and Indian patients.

Suppressor cells were assayed by numerical and functional tests in Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA) among African and Indian children in order to contribute to an understanding of the pathogenesis of these neurological disorders. Peripheral blood mononuclears (PBM) were classified as total T cells and T cell subsets by the OKT series of monoclonal antibodies and as B cells by the presence of surface immunoglobulin. The suppressive effects of PBM pretreated with concanavalin A (Con A) on normal homologous phytohaemagglutinin (PHA) transformation of mononuclear cells was determined. PBM stimulation by PHA was also assessed. Patients with DMD had a significant increase (P = 0.0353) in the number of T suppressor/cytotoxic cells (1218 +/- 142 cells/mm3, mean +/- SE) as compared to controls (815 +/- 95 cells/mm3) and a significant reduction (P = 0.0282) in OKT4+ cells expressed as a percentage of OKT3+, 50% +/- 3 compared to 61% +/- 3. No differences were detected in any of the numerical assays employed in SMA as compared to controls, or within SMA patients according to severity of disease. Suppressor function and PHA transformation were normal in both groups of patients. No significant correlations were detected between numerical and functional assays of suppression. The implication of the results obtained for the role of immunoregulatory cells in the pathogenesis of DMD in these children is discussed.

Adolescent↗
PubMed1988

Auditory brainstem responses (ABR) in children with neurological disorders.

Auditory brainstem responses (ABR) were studied in 35 children with neurological disorders and 24 controls. Abnormal results were obtained in 16 patients. All 5 of the patients with metachromatic leukodystrophy had evidence of peripheral and/or central delay in transmission in keeping with evidence of demyelination of both peripheral (i.e. auditory nerve) and central (i.e. brainstem) pathways as occurs in this disorder. Two children with lead poisoning had delayed conduction in the peripheral pathways only and in these there was good correlation between the degree of delay and the ulnar nerve conduction velocity; both improved after chelation therapy. One infant with lead poisoning had central delay only. One infant with osteopetrosis manifested progressive damage to the auditory nerves. Delayed conduction was also found in one patient each with hydrocephalus, spinal muscular atrophy, and in 2 infants with cerebral palsy. No responses were obtained in one infant with congenital rubella, one deaf-mute and one child with an undiagnosed degenerative neurological disease. Auditory brainstem responses are of value in detecting disturbances of the auditory nerve or brainstem in children with various neurological disorders.

Brain Stem↗
PubMed1987

Seventy black epileptics. Cysticercosis, computed tomography and electro-encephalography.

Computed tomography (CT) in a group of 70 black patients with epilepsy showed cerebral cysticercosis in 30%, with signs of activity in 12.9%. The possibility of effective treatment in active cysticercosis makes CT an important investigation of epilepsy in this population. Electro-encephalography is of some practical value in patients in whom CT is negative.

Adolescent↗
PubMed1987

Centronuclear myopathy in black African children--report of 4 cases.

Four African children with sporadically occurring centronuclear myopathy of the childhood form are described. Three were female. All had the characteristic clinical features of hypotonia, facial weakness, and external ophthalmoplegia. Muscle histology showed centrally placed nuclei in small type I fibres.

Africa↗
PubMed1987

Multiple pterygium syndrome in five Arab sibs.

This report describes an Arab family in which the parents are first cousins and with 5 siblings having multiple pterygium syndrome. The last pregnancy which produced an affected sib was prenatally diagnosed by ultrasonography. Intrafamilial variability of clinical features is discussed. The report stresses the importance of the differentiation between various genetic entities with multiple pterygium.

Adolescent↗
PubMed1986

Predictive value of C-reactive protein in neonatal septicaemia.

The following non-specific indices of infection were studied in septicaemic and non-septicaemic babies: haemoglobin, total white blood cell count, differential white count, ESR, platelet count, C-reactive protein (CRP), serum immunoglobulins, plasma C3 and haptoglobin. Forty-three low-birthweight (LBW) infants with clinical features suggesting septicaemia were investigated; blood cultures were positive in 19 and negative in 24. The mortality was 53% in the culture-positive and 13% in the culture negative group. Comparisons between the two groups of babies showed that the CRP titre (measured by Latex agglutination) was the only reliable non-specific indicator of infection. The titre was elevated more often in culture positive (16/19) than culture negative (7/17) babies (P less than 0.001). The CRP titre (Mean +/- 2 S.D.) was 15.75 +/- 12 in blood culture positive and 6.13 +/- 11.72 in culture negative neonates respectively (P less than 0.0004). Positive CRP titres were found in 5 of 20 healthy controls (4 +/- 8.4). Sequential CRP titres showed a gradual decline with clinical improvement in both groups of patients. The IgM was unhelpful as it was raised (greater than or equal to 40 mg%) in 37 of the patients.

C-Reactive Protein↗
PubMed1985

Honey in the treatment of infantile gastroenteritis.

A clinical study was undertaken using honey in oral rehydration solution in infants and children with gastroenteritis. The aim was to evaluate the influence of honey on the duration of acute diarrhoea and its value as a glucose substitute in oral rehydration. The results showed that honey shortens the duration of bacterial diarrhoea, does not prolong the duration of non-bacterial diarrhoea, and may safely be used as a substitute for glucose in an oral rehydration solution containing electrolytes. The correct dilution of honey, as well as the presence of electrolytes in the oral rehydration solution, however, must be maintained.

Child↗
PubMed1985

A comparison of traditional assessment with the objective structured clinical examination (OSCE).

As the objective structured clinical examination (OSCE) was being introduced into the medical curriculum, its validity was evaluated and the results obtained were compared with three components of the traditional assessment, i.e. tutors' mark, clinical assessment (long case) and multiple-choice questions (MCQs) in 170 5th-year students. The OSCE appeared to be a reliable and valid test of clinical skills, although this became apparent only with increasing experience. Traditional methods, in particular those which are inherently subjective, were found to upgrade students more often than OSCE scores. There were some correlations between OSCE marks and results of traditional examinations, especially the clinical assessment and the MCQ. Accordingly the OSCE appears to measure aspects of both clinical competence and theoretical knowledge. It has many advantages over traditional methods and should therefore be considered for inclusion in the assessment of medical students.

Clinical Competence↗
PubMed1985

The antibacterial action of honey. An in vitro study.

The reported antibacterial effect of pure honey was evaluated by an in vitro study testing the growth of various Gram-positive and Gram-negative bacteria in media containing varying concentrations of honey. It was found that most pathogenic bacteria failed to grow in honey at a concentration of 40% and above. The possible mechanisms of this effect are briefly outlined.

Bacteria↗
PubMed1984

Cerebral cysticercosis in children in South Africa.

Sixty-one children with cerebral cysticercosis are presented. The commonest clinical manifestation was epilepsy with or without focal signs in 43% of children, followed by the syndrome of raised intracranial pressure in 34% and meningoencephalitis in 13%. The CT scan was positive in 93% of cases and the HAI test in 86% of children so examined. Both were positive in 80%. Skull X-ray revealed evidence of calcification and/or raised intracranial pressure in 60%. Two children died, one each with subacute sclerosing panencephalitis and tuberculous meningitis. Of those who improved on discharge, 43% had epilepsy and 32% neurological deficit of an obvious nature. The parasitology, pathogenesis, pathology and diagnosis of cerebral cysticercosis are briefly reviewed. Present therapy and the suggested use of a specific anti-cysticeral drug are discussed. Case histories are presented to draw attention to the variability of the clinical picture and the particular importance of recognising the acute parenchymatous form of the disease in children which may present with critically elevated intracranial pressure.

Adolescent↗
PubMed1984

Diagnostic needle muscle biopsy. A practical and reliable alternative to open biopsy.

The technique of needle muscle biopsy using the Bergstr öm needle has been in routine use in our muscle clinic since 1978. In an initial feasibility study 24 children had a needle and an open biopsy performed simultaneously through extension of the same incision and 22 had identical interpretation of the needle and open biopsies. Needle biopsies have subsequently been performed in 674 children and have been satisfactory for diagnostic assessment in 656. The samples have been of adequate size and comparable in quality to our previous open biopsies, with good preservation and orientation. Needle muscle biopsy under local anaesthetic is quicker and less traumatic than open biopsy and leaves only a very small scar. Sufficient muscle can be obtained for routine histological, histochemical, and electronmicroscopic diagnosis, as well as for specialised biochemical and research purposes. There seems little justification for the continued use of open biopsy for routine investigation of neuromuscular disease.

Adolescent↗
PubMed1984

Serum MB-creatine kinase is not elevated in active rheumatic carditis.

Total serum creatine kinase (CK) and the MB fraction of CK (CK-MB) activities were measured in 36 patients with active rheumatic carditis and on 33 controls. There were no significant differences in either the total CK or the CK-MB between the two groups. However, eight out of the 36 carditis patients had received intramuscular injections (IMI) prior to the assay: this sub-group showed a significant elevation of the total CK but not the CK-MB. Ten carditis patients (without prior IMI) had repeat assays done after their rheumatic activity had subsided: the mean total CK, but not the CK-MB, fell to levels below control values although these were not statistically significant. The results show that CK-MB is not of value in assessing activity in rheumatic carditis. Further, in assessing the significance of elevated total CK in any clinical situation, the influence of IMI and of bed rest should be taken into account.

Child↗