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Biomedical subjects

A Montaner

Publications and source records attributed to A Montaner.

8 recordsLinked to original sources
PubMed1998

Infantile idiopathic scoliosis in the newborn.

We have reviewed 7 patients (5 boys and 2 girls) with infantile idiopathic scoliosis which was present at birth and was diagnosed at ages from 1 day to 1 month. The mean follow up was 16 years. The objectives were to discover whether intrauterine forces play a role in the aetiology and to determine whether early treatment of a potentially progressive curve can induce resolution. Two infants were male conjoined twins and were united by skin over the posterior sacrum. Six infants had a rib vertebral angle difference greater than 20 degrees in the first radiograph and 5 had stiff curves. In 2 with flexible curves, the deformity disappeared by the end of the first year. The 5 with stiff curves were treated conservatively for 6 to 24 months. Growth has now been completed in 5; 4 have a straight spine and one developed an adolescent curve of 26 degrees. The 2 who are still growing have no scoliosis. Intrauterine moulding was only demonstrated in the conjoined twins. There was a correlation between the rib vertebral angle difference above 20 degrees and the rigidity of the curve. Early treatment of a potentially progressive curve can lead to resolution.

Female↗
PubMed1994

[Obstructive candidiasis: a process with surgical solution].

We describe three severe clinic cases due to fungus balls of Candida albicans in hospitalized risky patients which presented a quickly clinical evolution. Because of their different local presentations medical and surgical management was needed. In the first case a intestinal fungus ball was found whereas in the other two cases were localized in the urinary tract. Here we present their clinical findings rather than their evolution after a medical and surgical management.

Adolescent↗
PubMed1989

[Esophagocoloplasty in the treatment of total caustic stenosis of the esophagus].

Since October 1986 until January 1988 we have treated 3 patients with corrosive strictures of the esophagus, by substitution of esophagus with vascularized colon. Two females (4 and 8 years) and one male (5 years) had been treated on others hospitals by means of gastrostomy and periodically retrogradual dilatations; in two of them for more than 24 months. The surgical treatment was indicated upon the evolution time, the degree of dysphagia and the size of the affected segment. The coloesophagoplasty by retrosternal approach with proximal anastomosis in the neck, has been the operative technique performed in the male case. On the others two cases, colon interposition by extrapleural thoracic approach, combined with laparotomy was carried out. We think that the coloesophagoplasty by retroesternal way should only be advised in cases were superior anastomosis in the neck is indicated, conditioned by the height of the stricture. On the other hand, colon interposition by extrapleural approach, is the elective way for the others cases.

Burns, Chemical↗
PubMed1989

[Role of somatostatin in the treatment of intestinal fistulas].

Somatostatin is a peptide hormone which inhibits the secretion of the growth hormone, and has proved to be a powerful inhibitor of exocrine pancreatic, gastric and intestinal secretion. It was therefore used as an adjuvant therapy in the conservative treatment of two children of eight and nine years old with fistulas of the small intestine. The first case was a colonic fistula for cecal defect, surgical intervention was carried out because treatment during 14 days with hormonal treatment after the third consecutive day of somatostatin application. In this study the authors present their experience with somatostatin, with particular emphasis on the indications contraindications, doses and lines for administration.

Abdominal Neoplasms↗
PubMed1978

[Neonatal functional intestinal obstruction of unknown etiology (author's transl)].

Three cases of newborn intestinal obstruction without obvious organic cause are reported. Narrow left colon (Davis's syndrome), small colon, megacystis and intestinal hypoperistaltism (Berdon's syndrome) and segmental bowel dilatation (Swenson's syndrome) were the diagnoses. Through a review of the literature a possible interrelationship among these three clinical entities at the level of an abnormal myenteric plexus neuronal function is discussed.

Dilatation, Pathologic↗
PubMed1975

Immunological studies in the postsplenectomy syndrome.

Variations in the serial immunoglobulins of 52 children splenectomized for a variety of indications were studied and compared with two groups of children, one postoperative and one without operation. The most significant finding was the constant decrease in Ig M in every instance. Our series of splenectomized children seems to confirm the facts noted by other authors. The incidence of serious infections has been clearly significant and is clearly postsplenectomy sepsis. The age of the patients has a great influence on the seriousness of the septic process, these being more severe on younger children. The influence has also been revealed of the cause which motivated the operation, this corresponding in the first place to thalassemia and in the second place through spherocytosis and pseudohormones. It is evident that the immunologic role of the spleen during early childhood, especially under the age of 5 yr is important. The greatest risk or postsplenectomy sepsis is in the first 2 yr of life. Splenectomy should be delayed until after the age of 5 if clinical circumstances permit. If not, prophylactic chemotherapy should be carried out during the first 18 mo after splenectomy.

Age Factors↗
PubMedDate not supplied

Epitope contiguous chains and antibody recognition in HIV-1 synthetic peptide antigens.

Five peptides derived from human immuno deficiency virus (HIV-1) gp41 transmembrane protein have been synthesized: M9 (610-618), M12 (598-609), M15 (600-614), M21 (584-604) and M23 (587-609). These sequences partially overlap in the region vicinal to the immunodominant epitope CSGKLIC, between two cysteine residues 603-609 and three of them (M12, M15 and M23) include this complete heptapeptide. M23, the longer peptide, includes an hydrophilic chain in addition to the heptapeptide loop. The purpose of this work was to determine the influence of contiguous chains to the heptapeptide loop on antibody recognition in fluid and solid phases, and dissociation constants (KD) of each sequence with human anti-HIV-1 antibodies. Two peptides, M13 and M23, overlapped on this loop, were found to be more reactive. Antigen-antibody dissociation constants were determined for both peptides by competition enzyme-linked immunosorbent assay, using each peptide alternatively as the solid phase-immobilized antigen. In addition to the influence of solid-phase antigen on calculated dissociation constants (a phenomenon described by Seligman, 1994), the inhibitory effect of M15 in liquid phase on antibody binding to solid phase M23 was higher than exerted by M23 in solution over antibody binding to M15 on solid phase. On the basis of peptide sequence and predicted antigenicity, this behavior appeared to be contradictory. It is assured that the possible origin of this phenomenon is due to unfavorable conformation of the longer peptide. Even though synthetic peptides mimic mainly sequential epitopes, conformational preferences in fluid or solid phase play an important role in epitope functionality. In particular, addition of residues to known immunodominant sequences may not always amplify antibody recognition if conformation provokes steric hindrance in the native epitope.

Amino Acid Sequence↗