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Biomedical subjects

A Momose

Publications and source records attributed to A Momose.

At least 55 records · Page 3Linked to original sources
PubMed1985

Scanning electron microscope study on the biodegradation of IOL and suturing materials.

The biodegradation of the IOLs (27 cases: mainly prepupillary lens with pupillary fixation, irido-capsular and angle supported lens and a J loop lens for posterior chamber lens) and suturing materials of four cases have been studied by Scanning Electron Microscope (SEM). The longest duration in the eye was 7.5 years and the shortest 0.3 year. The materials used for optics were PMMA with the exception of one case of glass. The materials for haptics were Nylon 6, Isot.PP, PMMA, PVDF, Polyimid and Pt-Ir. The suturing materials were Nylon 6 and Isot.PP. Nylon 6 degraded in the eye and Isot.PP degraded in the corneal tissue. But no biodegradation was observed in Isot.PP, PMMA, PVDF and Pt-Ir in the eye. In our investigations, biodegradation has some relationship to age (over 50 years old), duration (within 7.5 years) and inflammation of the eye, but ultimately biodegradation will depend on the individual situation. Degradation occurs most easily in the curved portion of Nylon 6.

Age Factors↗
PubMed1984

[Right ventricular free wall imaging using thallium-201 exercise myocardial scintigraphy with special reference to coronary angiography].

Right ventricular wall images of ischemic heart disease were evaluated during exercise myocardial scintigraphy using thallium-201. Among 33 subjects, ten were normal controls, 11 had left coronary artery disease (LAD group), 12 had right coronary artery disease (RCA group), all of whom received exercise myocardial scintigraphy. The submaximal or symptom-related ergometer exercise test was performed by the protocol being with 25 watt (W) loading, and then increased by 25 W every 3 min, while 3 mCi thallium-201 were injected intravenously at the maximal exercise point. Early imaging was obtained 5 min after exercise; delayed imagings, 1 and 4 hours after exercise. Early imaging and delayed imaging at 4 hours after exercise were obtained in the AP, lateral, LAO 30 degrees, LAO 45 degrees, and LAO 60 degrees projections. Only the LAO 45 degrees was obtained for delayed imaging 1 hour after exercise. To assess the radioactivity in the right ventricular wall, with regions of interest (ROI) in the upper part of the right ventricle [RV (U)] lower part of the right ventricle [RV (L)] and the most radioactive region in the left ventricle [LV (P)], we calculated the count ratio of the RV(U) or RV(L) to the LV(P) and defined it as the RV uptake ratio [RV(U)/LV(P)] or [RV(L)/LV(P)]. The results obtained were as follows: There were no significant changes in the RV uptake ratio between the early and delayed images both in the control and LAD groups, but the RV uptake ratio decreased significantly in the delayed images compared with an early image in the RCA group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Clinical estimation of the relation between coronary artery disease and regional myocardial blood flow by continuous thermodilution with the multithermistor catheter].

To evaluate coronary hemodynamics more precisely in ischemic heart disease, great cardiac vein flow ( GCVF ) and coronary sinus flow (CSF) were simultaneously measured before and during atrial pacing by a continuous thermodilution technique with the multithermistor catheter in 10 patients with significant coronary stenosis (narrowing of the left anterior descending artery of 75% or more) (Group 1: CAD) and 12 cases with the normal coronary artery (narrowing of 25% or less) (Group 2: NonCAD ). GCVF reflects the anterior regional flow of the left ventricle and CSF reflects total left ventricular flow. Between the two groups, no significant differences were noticed in either resting GCVF or resting CSF. However, atrial pacing induced a reduction of coronary resistance (CR) and increasing regional myocardial blood flow in both groups in the same way, and the maximal pacing provoked anginal episode in CAD group in which both the percent decrease of coronary resistance (CR) (% delta CRant 25.3% and % delta CRt 23.3%) and the percent increase of regional myocardial blood flow (% delta GCVF 49.6% and % delta CSF 40.6%) were lower than those in NonCAD group (% delta CRant 42.3%, % delta CRt 37.6%, % delta GCVF 80.6%, and % delta CSF 68.3%, respectively). These data imply that resting coronary blood flow may be maintained as normal in patients with angiographically significant coronary stenosis, though coronary reserve probably decreased in these patients. In this respect, the continuous thermodilution technique using the multithermistor catheter may be useful for the clinical estimation of coronary hemodynamics induced by various interventions. This technique can be performed repeatedly for a short time and permits simultaneous assessment of venous blood flow draining from the anterior wall and of total left ventricular flow.

Cardiac Pacing, Artificial↗
PubMed1982

Studies on effects of forphenicinol on immune responses.

The oral administration of forphenicinol, S-2-(3-hydroxy-4-hydroxymethylphenyl)glycine which was synthesized during the study of derivatives and analogs of forphenicine, augmented delayed-type hypersensitivity to sheep red blood cells and oxazolone in mice. The treatment with forphenicinol restored DTH in mice immuno-suppressed by cyclophosphamide to normal response. Forphenicinol neither augmented antibody-formation nor stimulated proliferation of lymphocytes in the presence or absence of lectins. Phagocytosis by peritoneal macrophages was enhanced by forphenicinol in vivo and in vitro. Forphenicinol was effective in increasing the production of CFU-C in the presence of colony stimulating factor and partially prevented the reduction of leucocyte counts caused by mitomycin C.

Adjuvants, Immunologic↗
PubMed1982

[The studies on distributions of cefsulodin and cefotiam to human aqueous humor and cornea].

Distributions of cefsulodin (CFS) and cefotiam (CTM), new parenteral cephalosporins, to human aqueous humor and cornea were studied in comparison with those of sulbenicillin (SBPC) and cefazolin (CEZ), and pharmacokinetic analysis was made by theory of compartment model, to obtain the following results. 1. Maximum aqueous humor levels of CFS and CTM were noticed at 2.5 hours after the start of 1 g CFS or CTM administration by 30 minute intravenous drip infusion, with the levels of 3.6 micrograms/ml and 4.2 micrograms/ml respectively. On the other hand, in case of 5 g SBPC or 2 g CEZ administration maximum aqueous humor levels were 12.5 micrograms/ml and 5.2 micrograms/ml respectively. 2. The ratios of maximum aqueous humor level to plasma level of the same time in CFS, CTM, SBPC and CEZ were 15.0, 16.8, 6.4% and 5.5%. Distribution of CFS or CTM was 2 to 3 times better than that of SBPC or CEZ. 3. From the result of pharmacokinetic analysis, ratios of aqueous humor to plasma levels in area under curves (AUC) of CFS, CTM, SBPC and CEZ were 25.6, 29.9, 16.4% and 7.9% respectively. Maximum aqueous humor levels of CFS, CTM, SBPC and CEZ were 2.9, 3.6, 11.4 micrograms/ml and 4.3 micrograms/ml and biological half life of gamma-phase were 2.57, 2.31, 2.77 hours and 2.24 hours respectively. 4. Cornea levels of CFS or CTM at one hour after the start of 1 g CFS or CTM administration by 30 minutes intravenous drip infusion were 2.9 micrograms/g and 5.2 micrograms/g, and their ratios to plasma level were 7.5% or 14.3% respectively. In case of 5 g SBPC or 2 g CEZ administration, the cornea levels were 26.7 micrograms/g and 5.0 micrograms/g, and the ratios were 9.4% and 3.4% respectively. 5. From the above, the distribution of CFS or CTM to human aqueous humor and cornea is better than that of SBPC or CEZ, and it is considered that clinical usefulness of both CFS and CTM by parenteral administration is expected in intraocular infections.

Aged↗
PubMed1980

Improved method for gas-liquid chromatographic determination of clopidol in chicken tissues.

A sensitive and specific gas-liquid chromatographic (GLC) method has been developed for determining low levels of clopidol in chicken tissues. Clopidol is extracted from the tissues with methanol, and cleaned up on an alumina column and an anion exchange resin column with 0.1% acetic acid--methanol as eluate. Clopidol is methylated with diazomethane, and then determined by GLC. 2,4-Dinitro-1-chlorobenzene is used as an internal standard. The method is applicable to levels as low as 2 ppb in chicken tissues. Recoveries of 2--20 ppb clopidol added to tissues averaged 87% for muscle, 84% for liver, 80% for kidney, and 76% for fat.

Animals↗