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Biomedical subjects

A Moine

Publications and source records attributed to A Moine.

10 recordsLinked to original sources
PubMed1991

[Our surgical experience of 20 extracochlear implantations on the oval window with transcutaneous approach].

While multichannel implants can produce far better results than single-channel implants, the results of a multichannel implantation are impossible to predict accurately preoperatively. Single-channel implants, which produce average and constant results, still have a major merit in that their cost is much lower. Since extracochlear implantation with transcutaneous approach is innocuous, we have been promoting this type of implantation as a temporary procedure until much more effective systems are found in the future, or as a definitive implantation.

Deafness↗
PubMed1990

Heterogeneity of HLA genetic factors in IDDM susceptibility.

The association of certain HLA-D alleles with insulin-dependent diabetes mellitus (IDDM) is well known. One hundred and sixty-one non-related diabetic individuals and 142 non-related healthy controls were typed for the HLA DR-DQw-Dw association, using a restriction fragment length polymorphism (RFLP) typing method that combines three probe/enzyme systems: DRB/Taq I, DQB/Taq I, and DQB/Bam HI. Comparison of frequencies in both diabetics and controls confirms previous results in terms of HLA class II and IDDM association. Moreover, we have found that DR3/3 heterozygous individuals are more susceptible to IDDM when they are also Dw25 (associated with B18) than when they are Dw24 (associated with B8). Using oligonucleotide dot-blot hybridizations we analyzed the HLA-DQB1 sequence of DR3,Dw24 and DR3,Dw25 homozygous individuals, and we found no difference at position 57 between these two DR3-carrying haplotypes. This observation points to the heterogeneity of HLA genetic factors in IDDM susceptibility.

Alleles↗
PubMed1990

[Trends in clinical research for one canal cochlear implantation].

Like any modality of perception, the processes of hearing can be divided up into two levels: modular or primary, and symbolic or central. Multiple-canal implantation is rather applied to the former mechanism, single-canal implantation to the latter. A bank of electrical signals recognizable from each other is being built up. It may be utilized in single-canal systems using this vocabulary to form sentences. The proper phonetic feature to be matched will then have to be selected.

Acoustic Stimulation↗
PubMed1990

[Atypical implants].

There is theoretically no major surgical problem for implantation. The basic techniques all include on an approach through the windows. The authors describe a solution (which has already been used previously) for cophotic hollowing-out cavities, with a suprapetrosal way and an approach on the hidden aspect of the cochlea. The transcutaneous passage can be displaced from the ear lobe to a depression of the auricle.

Cochlear Implants↗
PubMed1990

[Electrophysiologic studies in patients with cochlear implants].

The insertion of reliable extracochlear single-canal cochlear implants in cophotic and subcophotic patients allows the electrical stimulation of the acoustic nerve for rehabilitation, as well as audiovestibular explorations that are no longer possible in the acoustic mode. The authors therefore aim at replacing all these examinations with their Electrical equivalent: --early evoked potentials (E-BERA), --medium-latency evoked potentials (E-MLR), --Event-related evoked potentials (E-P300), for which, to our knowledge, theses are the first recordings, --electrical stapedial reflex, --vestibular stimulations. The method, results and clinical and physiological applications of each method are given, as well as its prospects.

Acoustic Stimulation↗
PubMed1990

[Tinnitus and implants].

The experience with cochlear implantation at Avicenne hospital prompted us to carry out a retrospective study on tinnitus in a population of operated patients. Improvement or disappearance of the symptoms was noted in all cases. These results, which partly match those found in the literature, are probably produced by rehabilitation inhibiting the "deafferentation" mechanisms in analogy with pain phenomena. In some precise cases, which are described, they led us to proposing implantation even though the main, if not sole, complaint of the patient was tinnitus.

Acoustic Stimulation↗
PubMed1990

[Deafness and sarcoidosis].

The cochleovestibular tract is seldom involved by sarcoidosis (about 50 cases have been described since 1948). As a clinical expression of sarcoidosis, deafness is fluctuant in 50% of all cases, bilateral, and most often associated with facial palsy and uveitis, the vestibular reflexes being reduced. The histological studies demonstrate lesions at all levels from the cochlea to be brain stem, but the main mechanism is an infiltration of the arachnoid vessels. The prognosis of sarcoidosis deafness is usually poor in spite of corticosteroid therapy. This paper is illustrated by 3 cases observed in Avicenne Hospital.

Adult↗
PubMed1985

Structural organization of the P25 gene of Bombyx mori and comparative analysis of its 5' flanking DNA with that of the fibroin gene.

We have cloned a large portion of the P25 gene of Bombyx mori encoding the 25,000 dalton polypeptide which associates with fibroin to constitute the major silk protein. Its structure has been investigated by restriction mapping R-loop analysis, S1 nuclease protection experiments and nucleotide sequencing of the region spanning the 5' end of the gene and its flanking DNA. This has permitted a comparative sequence analysis of the DNA from the P25 and fibroin genes. The genes demonstrate no relatedness in their coding regions but they exhibit large blocks of sequence homology in their 5' flanking regions. In particular, the DNA upstream of the P25 gene possesses a sequence very similar to a region of fibroin 5' flanking DNA that is known to possess transcription modulation signals. The functional significance of these homologous regions is discussed with regard to the highly coordinated expression of these two genes.

Amino Acid Sequence↗