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Biomedical subjects

A Mohr

Publications and source records attributed to A Mohr.

64 records · Page 4Linked to original sources
PubMed1986

[Acute myeloid leukemia (AML) in adults. Further development of therapy based on clinical phase II and phase III studies].

By a review of relevant clinical studies on adult AML no substantial progress can be seen in the eighties so far. After the development of successful chemotherapy regimens during the seventies, further improvement can only be expected in small steps. Clinical studies, therefore, should concentrate on the analysis of the different components and new elements of treatment in order to utilize and combine them more effectively. For this purpose, a standardization of treatment and, for many aspects, a randomized comparison is inevitable. Thus, the role of monthly maintenance as well as of a special type of immunotherapy could be elucidated for the first time by our multicenter trial.

Adult↗
PubMed1984

[Fold formations in the proximal ureter].

Over a period of thirteen years in 28 children (age 4 weeks to 11 years) mucosal membranes of the proximal ureter were diagnosed by intravenous urography. In 61% of all cases the anomalies were demonstrated within the first year of life. Predominantly boys were affected (75%). Most of the associated anomalies (n = 15) were related to the urogenital system (n = 7). The membranes were bilateral in 12 cases and either separate (n = 15) or multiple (n = 25), resulting in a cork-screw-like structure. Minor signs of obstruction of the corresponding renal pelvis were found in 45%, independent of the number of membranes. Urinary tract infection (UTI) occurred in half of all cases. Kidney length was not reduced in any child. The mean serum creatinin (SCR) level was 0.6 +/- 0.4 mg/dl. Surgical correction was never performed. The clinical follow-up investigation (n = 14) after a mean period of 5.1 (1-14) years revealed recurrent UTI in only 2 patients. The mean SCR level remained normal (0.5 +/- 0.3 mg/dl). The tendency of involution of the membranes, supposed by the clinically benign course, is demonstrated to serve as an example. Although a predisposing effect to UTI cannot be excluded, ureteral membranes must be regarded as harmless and transitory anomalies of the growing ureter in childhood which do not require urologic intervention.

Child↗