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Biomedical subjects

A Misefari

Publications and source records attributed to A Misefari.

At least 37 records · Page 2Linked to original sources
PubMed1980

Effect of prostaglandins on mouse erythrocyte rosette-forming human lymphocytes.

Prostaglandins (PGs) E2 and F2 alpha, preincubated with human lymphocytes for short periods of time inhibit mouse erythrocyte rosette formation. The presence of calcium ions does not influence this effect, which is dose-dependent and relatively temperature-independent. These observations indicate the PG treatment of lymphocytes may be useful to distinguish a subclass of IgM-bearing mouse erythrocyte rosette-forming B lymphocytes, which is sensible to the modulating effect of Pgs.

Animals↗
PubMed1980

Interaction between prostaglandins and human T lymphocytes: effect of PGE2 on E-receptor expression.

E-rosette formation is not modified by preincubation of lymphocytes with prostaglandins (PGs) E1, F1 alpha, and F2 alpha. On the contrary, short preincubation with PGE2 affects active rosette-forming cells (Ea-RFC) and, only slightly, total RFC. This effect appears to be dose-dependent and relatively temperature-independent; it does not require calcium ions. Incubation with a fraction enriched in late RFC showed that PGE2 does not affect late rosette formation. It is postulated that PGE2 may redistribute surface receptors for sheep erythrocytes on T lymphocyte membranes. Thus, sensitivity to PGE2 may be considered another difference between early and late RFC.

Animals↗
PubMed1971

Effect of beta-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice.

The analogue of phenylalanine, beta-3-thienylalanine (beta-3-TA), inhibits the primary and secondary immune responses to sheep red blood cells in CBA mice fed with phenylalanine-free diet. The optimal dose of beta-3-TA needed to obtain maximum immunosuppression with minimal toxicity is 250 mg per kg per day. The drug is maximally effective when administered for 7 days, beginning 2 days prior to primary immunization. With these experimental conditions, the antibody titers and the numbers of direct and indirect plaque-forming cells are greatly reduced during the primary and the secondary immune response.

Journal Article↗
PubMed1971

Effect of -3-thienylalanine on antibody synthesis. V. Immunosuppression in mice by short diet and drug treatments.

The analogue of phenylalanine, beta-3-thienylalanine, depresses severely the primary and secondary immune response to sheep erythrocytes in mice when administered for a few days immediately before and after each injection of antigen. For this immunosuppression to occur, animals must be maintained on a phenylalanine-free diet during the times of drug injection since dietary phenylalanine will restore anamnestic response. With these experimental conditions, the number of direct and indirect plaque-forming cells is greatly reduced during immune responses. The finding that marked immunosuppression can be obtained with a very short drug and diet treatment points to a potential usefullness of the analogue as a powerful immunosuppressant.

Alanine↗
PubMedDate not supplied

[The antistreptolysin activity of lysozyme].

The action of O-streptolysin on rabbit red corpuscles is inhibited by lysozyme, whereas the enzyme has no effect on termostable cytotoxic fraction of the toxin. Moreover little amounts of lysozyme canhance the anti-streptolysinic titers of human immune sera. These findings and the relationship between the biological activities of O-streptolysin are discussed.

Animals↗