Search PubMed⌕ Search

Biomedical subjects

A Minette

Publications and source records attributed to A Minette.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Ventilatory effect and side effects of oral bamifylline].

The results are in agreement with the hypothesis that 900 mg oral bamifylline, as a unique dose, should produce slight and temporarily bronchodilating effects. This phenomen may be discussed from the 30th minute after intake. It was significant after 2 hours and remained significant till the 4th hour. It is interesting to stress that this conclusion is in agreement with some isolated observations we could make before in our laboratory by means of injections or suppositories with the same product [9]. We did not observe facts suggesting a possible cumulative effect of the drug, when taken at a dosage of 3 times 900 mg regularly spread over the day. The drug seems to be perfectly tolerated. A 10 days' treatment with the above mentioned posology did not produce neither haematological, haepatic, renal, nor vascular side-effects which could be identified by the techniques classically used in these respective fields.

Adult↗
PubMed1978

Contribution to the standardization of pharmacodynamic tests in lung function.

By bringing the aerosols in a spirometrical bell from which a constant volume aerosol was thereafter inhaled by each subject through a bi-directional valve, we observed more consistent and reproducible ventilatory results than by giving the aerosols by means of a classical device via a face mask. Moreover the results were significantly higher with the first technique; this fact suggests that the quantity of inhaled broncho-active drug with suitable granulometry would have been on the average greater per minute with the first method.

Aerosols↗
PubMed1978

[The importance of epidemiology for research on pneumoconiosis in Belgium].

Epidemiological surveys of coal workers' pneumoconiosis are only possible by means of periodic X-ray examinations, repeated with a reasonable frequency in order to allow an identification of the first X-ray anomalies of simple pneumoconiosis in exposed workmen. Incidence studies to detect simple pneumoconiosis at its first stages and its progressive increase in cohorts of coal-miners whose dust exposure is known are indeed theoretically the best way to approach these problems. For many reasons, discussed in this paper, such incidence studies are nowadays impossible in Belgium. The survey technique used in our country is based on repeated transversal surveys. Its results are illustrated and commented.

Air Pollutants, Occupational↗
PubMed1977

An epidemiological survey of virus warts of the hands among butchers.

The prevalence of virus warts of the hands among butchers has been determined in three industrial butcheries by examining 536 meat-workers at their places of work. A prevalance of 23-8% has been found, which is significantly higher than the 8-5% prevalance found in 965 control adult subjects examined in different firms where manipulation of food does not occur. Further, the prevalence of virus warts of the hands has been found significantly higher in the 199 workers of one butchery (32-1%) than in 199 control subjects (10-1%) strictly matched for age and sex, and belonging to the same industrial area. In butchers, warts of the dorsal aspects of the hands are statistically less frequent than in control subjects when three localizations are considered (dorsal, palmar, dorsal plus palmar). No significant difference is observed when single localizations (dorsal or palmar) are considered. A definite explanation of the high prevalence of virus warts of the hands among butchers has not been found so far; some hypotheses are discussed in the light of the presnt study.

Adolescent↗
PubMed1977

[Long-term treatment with corticoids in respiratory disorders].

In a first chapter the author reviews the mechanisms of action of corticoids in respiratory diseases. Moreover the causes and the prevalence of unwanted side-effects are discussed. The advantages of synthetic glucocorticoids with short half-life time in pneumology are stressed. In the following chapters, the rationale of long-term corticoid treatments of asthma, in non allergic obstructive chronic lung diseases, in sarcoidosis and in the thoracic localisations of some collagen diseases is presented in detail. Regarding the treatment of asthma the author discusses the advantages of the alternate-day therapy, the use of corticoids in aerosols and the ratioale of ACTH. The usefulness of alternate-day therapy in sarcoidosis is also advocated.

Adrenocorticotropic Hormone↗
PubMed1977

The relationship between host factors of allergic nature and respiratory symptoms.

Respiratory symptoms and personal history of allergy were examined in 1659 children, including the entire elementary school population of four villages of the Belgian Ardennes. Levels of atmospheric pollution were monitored during the survey and proved to be very low. It is suggested that socio-economic factors produce a small increase in respiratory symptoms, particularly in cough symptoms. A personal history of eczema and of hay fever was highly associated with dyspnea and wheezing.

Air Pollution↗
PubMed1976

Lung function changes in smokers with normal conventional spirometry.

The comparative ability to detect early abnormalities in smokers by commonly used lung function tests was studied. Sixty-five healthy male nonsmokers served as a reference group and provided standards for 1-sec forced expiratory volume, vital capacity, end-tidal spirometry, spirometric forced mid-and end-expiratory flows, single-breath diffusing capacity, static lung volumes (helium method), and single-breath N2 closing volume measurements, In the present series of 80 male smokers, the measurements of forced mid-expiratory flow and forced end-expiratory flow did not improve the ability of the more conventional indices, 1-sec forced expiratory volume and the ratio of 1-sec forced expiratory volume to vital capacity, to detect obstructive lung disease. In 71 smokers with normal 1-sec forced expiratory volume and ratio of 1-sec forced expiratory volume to vital capacity, the end-tidal spirometry, diffusing capacity, and residual volume indices revealed 14,20, and 21 per cent of abnormalities. respectively. The single-breath N2 closing volume test (Phase IV/vital capacity and slope of Phase III) detected the greatest number of subtle changes in lung function; this was abnormal in 32 per cent of smokers with normal conventional spirometry. In young or light smokers, Phase IV/vital capacity was more frequently increased than the slope of Phase III; an incerse trend was observed in older or heavier smokers. The single-breath N2 closing volume test also provided the greatest number of abnormal results when other indices were impaired in the same subjects.

Adult↗
PubMed1975

[Reflections on 19 cases of asbestosis discovered by chance in the population of an industrial region in the Basse-Sambre].

The authors describe 19 cases of definite or highly probable asbestosis which were observed among unselected out-patients at a hospital in the industrial area of the "Basse-Sambre". These cases were of various types and were, almost exclusively, of occupational origin. The variety and severity of the asbestosis in many of the cases justify a more thorough survey in this area. Those people who have handled and inhaled asbestos fibres at work will be examined in the first place. A radiological pulmonary survey will also be organized among the people living in the neighbourhood of factories using asbestos. Precise information about the origin, quality and characteristics of the inhaled dust as well as the intensity and duration of exposure will be obtained. Cases discovered in the survey will be investigated systematically by means of an extensive range of techniques: frontal and oblique X-rays with an appropriate kilovoltage for the detection of pleural calcifications and of the reticular thickening of the parenchyma; spirometry and measurement of the transfer factor for CO; arterial blood gases at rest and during exercise; search for ferruginous bodies in sputum; pathological studies of pulmonary and pleural tissues and of the ultrastructure of pleural tumours.

Aged↗