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Biomedical subjects

A Mikata

Publications and source records attributed to A Mikata.

At least 91 records · Page 5Linked to original sources
PubMed1988

Radiation therapy of the nasopharyngeal cancer and its prognostic factors.

39 patients with the regional nasopharyngeal cancer (NPC) underwent radiation therapy from 1975 through 1984 in the Department of Radiology, Chiba University Hospital. A retrospective study was carried out to find out prognostic factors of these NPC patients. Radiation therapy was performed under megavoltage condition. 31 patients were given more than 50 Gy. 41% of the whole had T4 extension and 69% had lymph node metastasis. The pathological slides were reviewed and classified by the proposal of Shanmugaratnam. Advanced N-stage and the absence of the lymphocytic infiltration tended to affect the survival unfavorably, whereas the prognostic significance of histology, especially of keratinizing squamous cell carcinoma remained unclear. T4 lesion often recurred even with high dose radiation therapy. To improve the local control rate in NPC, wide field irradiation from the base of skull to the lower neck seemed necessary as well as the dosage greater than 66 Gy.

Ethnicity↗
PubMed1988

[Non-Hodgkin's lymphoma in patients aged 70 or older].

Fourty-one patients, referred to the Department of Radiology, Chiba University Hospital from 1975 through July, 1987, have been analyzed to determine their prognostic factors. These patients showed a less favorable prognosis (2 and 5 year actuarial survival, 30% and 19% respectively) compared with the younger patients. The histological grade by WF and their clinical stage reflected the prognosis well. Although the achievement of complete remission seemed to affect prognosis favorably, aggressive regimens with chemotherapy and/or radiotherapy often caused their deaths. In senile patients with NHL, it is a prerequisite to consider the effects on the patient of curative therapy more carefully, especially when Adriamycin is used.

Aged↗
PubMed1988

An immunohistochemical and ultrastructural study of an unusual case of multiple non-X histiocytoma.

An immunohistochemical and ultrastructural study of an atypical case of multiple non-X histiocytoma was done. There was involvement of the skin, lungs, and liver in a 3-month-old male infant. Microscopic examination of the cutaneous tumors revealed a dense infiltration of cells with polymorphous large nuclei and abundant eosinophilic cytoplasm in the entire dermis. Both immunohistochemical and electron microscopic studies suggested that the tumors were non-X histiocytomas. The patient's condition deteriorated with dyspnea due to rapid enlargement of tumor masses in the liver and lungs. However, at 5 months of age, the cutaneous nodules and pulmonary and hepatic lesions showed a tendency to involute. Furthermore, at 12 months of age, they were no longer detectable. The patient at 24 months of age was well with normal development. To date, no recurrence of the disease has been observed.

Biopsy↗
PubMed1987

Primary spinal epidural Burkitt's lymphoma.

Three Japanese children suffered from symptoms of spinal cord compression, and myelography demonstrated extradural masses compressing the spinal cord at different levels. Decompressive laminectomy revealed epidural tumors which were resected as completely as possible. Histologic pictures of the tumors showed Burkitt's lymphoma, and the diagnosis of primary epidural Burkitt's lymphoma with clinical stage A was made in each case after postoperative examination. Though postoperative radiotherapy and systemic chemotherapy were administered to all patients, they only survived for a short period of time.

Burkitt Lymphoma↗
PubMed1986

Histogenesis of alveolar soft part sarcoma. An immunohistochemical and biochemical study.

In order to clarify the histogenesis of alveolar soft part sarcoma (ASPS), an immunohistochemical and biochemical study was performed on three cases. The immunohistochemical study indicated the presence of actin, desmin, vimentin, and Z-protein in all cases. On the other hand, intermediate filaments other than desmin and vimentin were not detected immunohistochemically. The presence of desmin and Z-protein strongly suggests the myogenic character of this tumor. As to whether ASPS shows striated muscle differentiation or smooth muscle differentiation, the immunohistochemical absence of myoglobin in the three cases suggests that the tumor does not differentiate in the direction of striated muscle. However, biochemical assay of subunits of enolase revealed significantly high amounts of beta-enolase, which is known as a marker for striated muscle, in all three cases. The determined values--735, 426, and 584 ng/mg of protein --are indicative of striated muscle differentiation. In addition, the immunohistochemical study of all cases revealed the presence of beta-enolase in tumor cells. These data definitely show the myogenic character and rhabdomyoblastic differentiation of ASPS.

Actins↗
PubMed1985

Cellular differentiation of epithelioid sarcoma. An electron-microscopic, enzyme-histochemical, and immunohistochemical study.

For the purpose of clarifying cellular differentiation of epithelioid sarcoma, studies based on various methods were performed. Enzyme histochemical studies showed that epithelioid sarcoma tumor cells have characteristics intermediate between epithelial cells and the large plump cells of synovial sarcoma-incomplete epithelial differentiation. For alkaline phosphatase and adenosine triphosphatase particularly, positive cells and negative cells coexisted, as in the large plump cells of synovial sarcoma. Immunohistochemical studies for alpha 1-antitrypsin, alpha 1-antichymotrypsin, vimentin, and keratin also showed that epithelioid sarcoma tumor cells are very similar to the large plump cells of synovial sarcoma and have incomplete epithelial differentiation. For example, the examinations of serial sections and double staining methods revealed that keratin-positive cells are always vimentin-positive in epithelioid sarcoma and in the monophasic area of synovial sarcoma. Electron-microscopically, bundles of intermediate filaments and filopodia toward the intercellular lumen were observed, as in the monophasic area of synovial sarcoma. The results of enzyme-histochemical and immunohistochemical studies of non-neoplastic synovial lining cells, performed here for the first time, are also discussed.

Adenosine Triphosphatases↗
PubMed1984

Immunologic characterization of Reed-Sternberg cells and other cell components in lymph nodes with Hodgkin's disease.

Seven lymph nodes from patients with Hodgkin's disease were immunologically studied. Histologically these cases consisted of 3 lymphocyte predominance, 2 mixed cellularity, and 2 nodular sclerosis. Positive staining of mononuclear Hodgkin- and multinuclear Reed-Sternberg (RS) cells were obtained with anti-Ia like antigens and OKT9 (anti-transferrin receptor) monoclonal antibodies. No supportive data for discussing similarity of RS cells with ordinary histiocytes, B-lymphocytes or T-lymphocytes were obtained from the study of surface phenotype, although some analogy was present with histiocytes. Small lymphocytes around RS cells were helper/inducer T-lymphocytes, and the relationship between these T lymphocytes and RS cells was discussed.

Adult↗
PubMed1984

Clinical episodes of granulomatous pneumonitis. Repetition during four consecutive summers.

From summer to mid-autumn for four consecutive years (1974 to 1977), a 50-year-old woman barber experienced cough and exertional dyspnea with sputum production. Rales were audible at the posterior lung bases bilaterally. Her chest x-ray film showed diffuse nodular shadows, and pulmonary function studies revealed markedly decreased DCO. Open chest lung biopsy was performed and granulomatous lesions with multinucleated giant cells without central necrosis were observed. Having experienced multiple episodes for four years, she ceased to show symptoms after demolishing and reorganizing her house. This case is thought to represent the typical summer-type hypersensitivity pneumonitis, which we have subsequently found to be the most prevalent form of hypersensitivity pneumonitis in Japan.

Alveolitis, Extrinsic Allergic↗
PubMed1984

Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia.

A case of lymphoid hyperplasia with prominent plasmacytic proliferation histologically and with polyclonal hypergammaglobulinemia and anemia clinically was reported. This condition in a 54-year-old Japanese male was probably a type of plasma cell dyscrasia similar to a plasma cell variant of Castleman's disease. About 19% of apparently nonatypical lymphocytes in the biopsy material of this case were found to have ribosome-lamella complexes (RLC) similar to those previously described in patients with hairy cell leukemia and some other hematologic disorders. An intimate association with the rough endoplasmic reticulum of these structures suggested aberrant protein synthesis by B-lymphocytes.

Anemia↗
PubMed1984

Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study.

For the purpose of clarifying the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS) as well as the problem of whether or not CCS is a heterogeneous group of neoplasms, studies based on various methods were performed. Analysis of glycosaminoglycans gave the same results for amelanotic CCS and synovial sarcoma, and the DOPA reaction gave the same negative results for amelanotic CCS and synovial sarcoma. However, the DOPA reaction was also negative in an amelanotic recurrent tumor of a melanotic CCS, and electron-microscopic studies revealed a close resemblance between amelanotic CCS and melanotic CCS. Further, enzyme histochemical studies showed definite differences between synovial sarcoma and amelanotic CCS but gave identical results for amelanotic and melanotic CCS. Immunohistochemical studies revealed the presence of S-100 protein in all CCS cases, both amelanotic and melanotic. These results indicate that CCS is not a heterogeneous group of neoplasms, and that both amelanotic and melanotic CCS are of neural crest origin.

Adult↗
PubMed1984

Alveolar soft part sarcoma. An elaboration of a three-dimensional configuration of the crystalloids by digital image processing.

As an initial step to elucidate the nature of the unique characteristics of the crystalloids of alveolar soft part sarcoma, a three-dimensional model of the crystalloids was prepared by digital image analysis of electron micrographs by computer. It was revealed that occult periodicities are present at two intervals, 60 A and 380 A, in the filamentous structure of the crystalloid; and it was also revealed by the observation of each cross-section that two globular substances with a diameter of 60 A are arranged in a dumbbell pattern in each filamentous structure. The model prepared based on these data showed the double strands crossing each other at intervals of 380 A, each of which consists of successive arrangement of the globular substances with a diameter of 60 A. This structure is clearly similar to that of actin. The similarities and differences between these results and the well-known studies of the organization of naturally occurring actin bundles are discussed.

Adult↗