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Biomedical subjects

A Meulemans

Publications and source records attributed to A Meulemans.

85 records · Page 5Linked to original sources
PubMed1981

Pharmacokinetics of gentamicin in perilymph and endolymph of the rat as determined by radioimmunoassay.

The kinetics of gentamicin in the inner ear fluids of the rat were studied with a sensitive radioimmunoassay. Continuous infusion over a broad range (7.5--150 micrograms/min) was used to obtain equilibrium. The lowest rate of infusion produced plasma concentrations after 45 min that were within the range of peak serum levels desirable in humans. The purity of perilymph and endolymph was ensured by measurement of sodium and potassium concentrations. The concentration of gentamicin in perilymph was linearly related to its concentration in plasma, which depended on the rate of infusion. After six days of constant infusion of gentamicin at 15 microgram/min, the concentrations in plasma, perilymph, and endolymph averaged 25.8, 5.1, and 1.2 micrograms/ml, respectively, for five of 11 rats. Gentamicin cleared from the perilymph with a half-life of 3 hr.

Animals↗
PubMed1981

Radioimmunoassay of gentamicin in microliter and nanoliter samples of biological fluids.

A gentamicin radioimmunoassay is described for microliter and nanoliter samples. The assay was performed in the inner ears' fluids (perilymph and endolymph) of rats. Endolymph and perilymph samples were collected under oil with a glass capillary micropipette. The absolute threshold of sensitivity was 20 . 10(-12) g. Considering the maximum sampling volume, 15--400 . 10(-9) and 10 . 16(-6) l for endolymph and perilymph respectively, the limit of detection is 4.19 . 10(-4) microM . ml-1 in endolymph, 1.26 . 10(-4) microM . ml-1 in perilymph. Clinical applications of this method are suggested.

Animals↗
PubMed1980

[Not Available].

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Belgium↗
PubMed1980

[Not Available].

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Belgium↗
PubMed1980

Six years experience with an emergency department based mobile emergency care delivery system.

The purpose of mobile emergency care is to provide on a basis of 24 hours out of 24, the necessary material (ambulances wiwth resuscitation equipment) and personnel (ambulance-drivers, nurses and doctors), in order to care for the victim of accident or sudden illness on the spot and during transport to the hospital. The experience gained with a mobile emergency care delivery system, organized within the Emergency Department of the University Hospital Sint-Rafaël Leuven, Belgium, is analyzed and discussed. The conclusions of the study stress the advantages, as far as economics and efficiency are concerned, of the integration of the mobile emergency care delivery system in the emergency department of the highly specialized university hospital.

Adolescent↗
PubMed1979

A bone-fixing trephine for large-diameter iliac biopsies in dogs.

For experimental studies of bone in dogs it may be necessary to collect from the iliac crest biopsies of a larger diameter than is usually obtainable. A disadvantage of using a trephine with a large bore is that the biopsy may be pulled out of the trephine by the forces exerted by tendons inserted in the medial cortex of the ilium. To overcome this difficulty we developed a trephine with an internal bore of 10 mm combined with a biopsy-fixing attachment.

Animals↗
PubMed1979

[Not Available].

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Belgium↗
PubMed1979

[Not Available].

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Belgium↗
PubMedDate not supplied

[An integrated emergency medical care system at the University of Leuven].

There are three motives to start an organized medical emergency care system: to provide a systematic approach to all admitted medical emergencies in a specific structure in the hospital. to decrease mortality and morbidity by immediate evaluation and treatment of vital functions. to supply adequate emergency care for the region. These motives can only be realized through well-known options: the system must be multidisciplinary. excellence in critical care medicine must be available at all times. a system of mobile medical emergency care must be developed. all available regional emergency care facilities must be integrated. Only this way can the emergency service evolve as the central link of critical care medicine.

Ambulances↗