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Biomedical subjects

A Messina

Publications and source records attributed to A Messina.

At least 127 records · Page 7Linked to original sources
PubMed1988

[The Ilizarov method for lengthening and correction of the ulna in radial club hand].

The revolutionary method of treatment of fractures and their complications according to Ilizarov' can also be applied in congenital deformities. Ilizarov uses "compactotomy" and distraction of 1 mm a day, in order to cause a "driving osteogenesis" and the stimulus to regenerate the bone and soft tissues near it and connected to it. In this way it is possible to obtain progressive lengthening of a limb or bone fragment. Bone stumps are fixed with crossed Kirschner wires, and such as we can obtain at the same time a lengthening of nerves, vessels, tendons, muscles; and that, in one of his patients, Ilizarov succeeded in reaching an elongation until 25 cm! Our patient is a 12 years old boy, affected by bilateral radial club hand, congenital heart and kidney diseases. After both wrist centralization requiring soft tissues release, we established that the right forearm showed persistent shortening and radial bowing of the ulna. So we used the Ilizarov's method, mending both deformities and reaching an elongation of the ulna of 7.5 cm. A remarkable both functional an aesthetic improvement of the forearm has been also obtain without any loss of function of soft tissues, such as trophic troubles, functional loss of vessels, nerves, tendons, muscles and skin.

Bone Lengthening↗
PubMed1987

Intercellular spaces between macula densa cells: an ultrastructural study comparing high pressure perfusion fixation with in situ drip-fixation of rat kidney.

In situ drip-fixation of superficial glomeruli and tubules in the rat kidney verified the results obtained from high pressure perfusion fixation studies indicating that distinct spaces normally exist between the cells of the macula densa. Following treatment with frusemide these intercellular spaces between the macula densa cells became closed in both drip-fixed and perfusion-fixed kidneys. These findings suggest that the variability of extracellular compartmentation found in the macula densa is unlikely to be an artifact but most likely represents changes in the in vivo status of the macula densa.

Animals↗
PubMed1987

Steroids and orbital blowout fractures--a new systematic concept in medical management and surgical decision-making.

Thirty-eight patients with computed tomography (CT)-proven orbital fractures and diplopia were studied prospectively to determine the efficacy of steroids in the medical management of orbital fractures. The protocol is based on double-blind assignments to steroid (ST) and non-steroid (NT) treatment groups. Outcome analysis was based on sorting fractures into three CT classes: I-without soft tissue prolapse (n = 15); II-with soft tissue prolapse (n = 14); and III-CT evidence of inferior rectus entrapment (n = 9). Results included resolution of diplopia without surgery in both ST and NT groups in CT classes I and II. Median time course of resolution was compressed to less than 5 days in the ST treatment group, however, versus 13 days in the nontreatment group. All fractures in class III had residual diplopia with five of nine patients having surgical results that were enhanced in the ST treatment group. In addition, enophthalmos was unmasked in the ST treatment group within 1 week of treatment versus 5 months without treatment. A protocol for medical management and surgical decision-making in blowout fracture is presented.

Double-Blind Method↗
PubMed1987

Glomerular epithelial abnormalities associated with the onset of proteinuria in aminonucleoside nephrosis.

A sequential ultrastructural study has been made of glomerular podocytic epithelium before and after the onset of proteinuria induced by daily subcutaneous injections of low doses of puromycin aminonucleoside (PAN). At 4 days, before the onset of proteinuria, the principal change was extensive replacement of podocytic foot processes by broad expanses of epithelial cytoplasm. At 5 days, when proteinuria had developed, the epithelial cells showed in addition multiple cytoplasmic droplets, many large balloon like vacuoles, some of which were ruptured, and many foci of epithelial detachment from the glomerular basement membrane (GBM). Of particular significance, the onset of proteinuria coincided precisely with the development of areas of epithelial detachment that led to direct continuity between externally denuded GBM and the urinary space. It seems likely that these areas are the primary sites of protein leakage across the GBM in this experimental model.

Animals↗
PubMed1986

[Autoplastic foot-to-hand joint transplantations].

Our surgical experience in the field of total and partial foot-to-hand joint transplants has evolved over the past 9 years (1973). In the case of serious traumatic injury of finger joints of the hand, we don't suggest any surgical solution other than that of arthrodesis or arthroplasty of the damaged joint. In our experience joint transplantation is a reconstructive operation of the whole functionality of the injured finger. This operation partially restores the active function of the finger involved and gives both the patient and the surgeon the possibility of an alternative to arthrodesis, arthroplasty or painful instability of the destroyed joint, thus avoiding their characteristic disabilities. The transplantation guarantees a true stability of the joint and in the majority of cases the disappearance of pain. The technique described are the result of our experience in treating our clinical cases which consist of 20 patients treated, over more than 9 years at the Division of Hand Surgery of Traumatologic and Orthopaedic Center of Turin. The total number of transposed joints is 22, 16 of which are hemiarticular grafts. The operations have concerned 8 M.P. and 14 PIP joints of the fingers.

Adult↗
PubMed1985

Glomerular podocytic injury in protein overload proteinuria.

Injection of rats with large doses of bovine serum albumin causes proteinuria which may persist long after the period of overload has ended. In order to assess in this model of proteinuria the relative importance of podocytic epithelial changes versus alterations in anionic groups in the glomerular capillary wall a morphological study has been made of animals in which the kidneys were fixed by vascular perfusion or by in situ drip fixation. By transmission electron microscopy, podocytes showed protein droplets, cytoplasmic vacuoles, spreading of epithelial cytoplasm with loss of foot processes, and focal separation of epithelium from the glomerular basement membrane, occasionally with cytoplasmic disruption. Staining with colloidal iron showed no reduction in the density of anionic groups per unit area on epithelial cell surfaces or elsewhere in glomeruli. However, the reduced surface area of epithelial cells caused by the changes to their structure accounts adequately for the less intense glomerular colloidal iron staining evident by light microscopy. Changes in podocyte structure, particularly those leading to focal cytoplasmic defects on the outer surface of the glomerular basement membrane, appear to be more important than loss of glomerular anionic groups for the development of proteinuria in protein overload nephropathy.

Animals↗
PubMed1982

Treatment of recent lesions of the dorsoradial compartment of the metacarpophalangeal (MP) joint of the thumb.

Lesions of the dorsoradial compartment of the metacarpophalangeal joint of the thumb, are encountered more rarely than rupture of the internal collateral ligament and are considered a less serious or complex lesion. However, the alteration of the various structures, at the level of the metacarpophalangeal joint, produces, a severe deformity. It is an injury that requires early surgical repair of these structures. The author describes the physiopathology of the injury and the surgical technique for correcting the deformity on the basis of a series of operated cases.

Adult↗
PubMed1979

Immuno-deficiency in Schwartz-Jampel syndrome.

Two sisters born in a consanguineous marriage and affected by Schwartz-Jampel syndrome had a complex immunodeficiency, involving not only the humoral but also the cellular immune response.

Abnormalities, Multiple↗
PubMed1976

Human maternal and fetal serum insulin and growth hormone (HGH) response to glucose and leucine.

Maternal and fetal serum insulin and HGH responses to glucose, leucine, and glucose plus leucine were examined by infusions to pregnant women at term immediately before cesarean section. Leucine (15 gm.) with glucose (50 gm.) administered for 30 minutes to the mothers stimulates markedly maternal and fetal insulin secretion while infusion of glucose (50 gm.) causes a lower insulin response. When infusing glucose alone we noted that the duration rather than the degree of hyperglycemia determined the fetal insulin response. In fact, when glucose is given to the mother for 60 minutes the fetal insulin response is higher than when the same dose is infused for 30 minutes. Maternal infusion of leucine (15 gm.) for 30 minutes elicits only a very slight increase of insulin secretion in the mother and no change in the fetus. None of the infusions causes any alteration whatsoever in either maternal or fetal HGH secretion.

Blood Glucose↗
PubMed1975

Effect of glucose priming on insulin response in the premature infant.

Our paper deals with premature infants in the first twenty-four hours of life and reports the effect of a preinfusion of glucose on glucose administration. Glucose infusion (2.5 gm.) resulted in a slight elevation of serum insulin. When this administration of glucose was preceded by a two-hour infusion of glucose, there was a striking increase in serum insulin.

Glucose↗