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Biomedical subjects

A Menter

Publications and source records attributed to A Menter.

44 records · Page 3Linked to original sources
PubMed1989

Erythrodermic psoriasis. Precipitating factors, course, and prognosis in 50 patients.

Erythroderma represents the most severe form of psoriasis. In addition to its morbidity and severe discomfort, erythrodermic psoriasis also may be potentially life-threatening. We present demographic, clinical, and laboratory findings of 50 patients with psoriatic erythroderma seen at our day-care center during a 9 1/2-year period. Precipitating factors included administration of systemic corticosteroids and the excessive use of topical steroids, phototherapy complications, severe emotional stress, and preceding illness. Treatment options are discussed on the basis of an average follow-up period of 34 months. There appears to be a certain subgroup of patients with highly unstable psoriasis for whom appropriately planned therapeutic regimens are essential.

Adult↗
PubMed1989

Recurrent renal cell carcinoma presenting as skin nodules: two case reports and review of the literature.

The skin is a relatively rare site for metastatic carcinoma compared to other organs such as bone, lung, and liver. Once it is discovered, however, the underlying disease has usually become widespread. We describe two patients with recurrent renal cell carcinoma who presented with skin nodules six and ten years, respectively, after their initial cancers were diagnosed. Treatment options and prognostic factors are outlined and dermatologists are urged to consider neoplastic disease when confronted with patients presenting with acute, asymptomatic skin nodules.

Aged↗
PubMed1985

Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy.

Pruritus is a frequent and troublesome consequence of end-stage renal disease. We have surveyed 155 chronic dialysis patients and found pruritus to be a significant problem in approximately 70%. Seventeen patients reporting severe pruritus were treated thrice weekly with total body exposure to either UVA or UVB light. UVB light resulted in resolution of pruritus in all cases. UVA light was without significant effect. Skin biopsies obtained before and after UV phototherapy revealed elevated contents of calcium, magnesium, and phosphorus in all pruritic patients. The resolution of pruritus following UVB treatment was associated with a reduction of skin phosphorus to values comparable with nonpruritic uremics or healthy volunteers. Uremic pruritus may be due to increased skin divalent ion content resulting in microprecipitation of calcium or magnesium phosphate.

Biopsy↗
PubMed1985

Ochronosislike pigmentation from hydroquinone bleaching creams in American blacks.

Two patients had pitch-black pigmentation and colloid milium formation following the use of 2% hydroquinone-containing bleaching creams. These are among the first known cases in American blacks, although this phenomenon has been recognized previously in African blacks. Ultrastructural studies indicated that the pigment was due to the formation of elastotic fibers. These fibers attained an enormous size and disintegrated, leaving irregular fibers and fragments dispersed in the dermis. It is important that this clinical picture be recognized, since the use of these bleaching creams is widespread.

Black or African American↗
PubMed1983

The Goeckerman regimen in two psoriasis day care centers.

Three hundred patients with severe psoriasis were treated with the Goeckerman regimen in two different day care centers. Each patient was personally evaluated and followed by us for a period of 1 year or longer in an effort to determine accurately clearing of the skin, side effects, and length of remission. The average duration of treatment to produce over 90% clearing of the skin was 18 days. Ninety percent of the patients remained clear for a minimum of 8 months, and 73% were clear for 1 year or longer. The average total body dosage of ultraviolet B (UVB) needed to clearing was 1.96 joules/cm2. Side effects were minimal, and there was no increase in skin cancer. The cost-effectiveness of the regimen in a day care center is comparable to psoralens and ultraviolet A (PUVA) therapy.

Adolescent↗
PubMedDate not supplied

Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study.

A multicenter, double-blind, randomized, parallel-group trial compared tazarotene 0.1% cream with adapalene 0.1% cream, once daily for 12 weeks, in 173 patients with facial acne vulgaris. Tazarotene was associated with a significantly greater incidence of patients achieving 50% or greater global improvement (77% vs. 55%, P < or = .01), and a significantly greater reduction in comedo count (median of 68% vs. 36%, P < or =.001, compared with adapalene. A significant between-group difference in baseline inflammatory lesion count precluded a comparison of efficacy against inflammatory acne. The most common adverse events were dryness, peeling/flaking, itching, redness/erythema, burning, and facial irritation with comparable incidences of each between groups. Mean peeling and burning levels were milder with adapalene, though were trace or less in both groups throughout. There were no significant between-group differences in the incidence of patients discontinuing due to lack of efficacy or adverse events. Tazarotene cream offers significantly greater efficacy and comparable tolerability to adapalene cream.

Acne Vulgaris↗