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Biomedical subjects

A Mendizova

Publications and source records attributed to A Mendizova.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Serum immunoreactive trypsin in chronic pancreatitis patients].

The serum immunoreactive trypsin (determined by RIA-gnost Trypsin of the firm Höchst) was studied in 30 patients with chronic pancreatitis: 16 patients in a stage of exacerbation and 14 patients with clinical remission. Via pancreozymin-secretin test pancreatic exocrine insufficiency was established in all patients: 24 patients with moderate disorders and 6 patients with total secretory deficiency. The results were compared with a control group of 13 healthy subjects. In the mixed group of patients with chronic pancreatitis, serum immunoreactive trypsin did not differ from that of the control group (p greater than 0,05). The values of immunoreactive trypsin in serum, in the patients with chronic pancreatitis in a stage of exacerbation, are higher, with a statistical significance (p less than 0,001). In chronic pancreatitis, in a stage of remission, the level of serum immunoreactive trypsin is significantly lower as compared with the control group (p less than 0,01). The determination of serum immunoreactive trypsin could be used as a test in the diagnostics of recurrences of chronic pancreatitis but it is not a sure marker for the presence of pancreatic exocrine insufficiency.

Chronic Disease↗
PubMed1984

[Treatment of duodenal ulcer with Zantac-ranitidine].

The results from the treatment with the preparation Zantac -Ranitidine of 30 patients with duodenal ulcers are reported. The treatment was carried out with 2 X 150 mg ranitidine daily for 20 days. As early as the second or third day after the initiation of the treatment, the pain disappeared in 96,6 per cent, the sense of heaviness and eructation -- in 100 per cent, pyrosis and palpation pain -- in 96,6 per cent an nausea - in 93,3 per cent. All indices of the gastric secretion (V, BAO, MAO and PAO) were reduced with a statistical significance after 20-day ranitidine treatment, as compared with the initial values. Epithelization (healing) of the ulcer was fibroendoscopically established in 73,3 per cent by 20th day, and by 40th -- in 93,3 per cent. The bigger ulcers were more slowly epithelized . Ranitidine was very well tolerated and gave no adverse effects. Better results, with a statistical significance, were obtained with ranitidine treatment of the duodenal ulcer, both as regards the effect on the subjective symptoms and epithelization of the ulcer as compared with the control group.

Adult↗
PubMed1984

[Computed tomography and echography in chronic pancreatitis and pancreatic carcinoma].

The diagnostic possibilities of computer tomography and echographic investigations were studied in 58 patients with chronic pancreatitis and 36 patients with carcinoma of pancreas. Positive morphological signs for the existence of chronic pancreatitis were established in 75,9 per cent in computer tomography and in 83,93 per cent in echographic investigations. The difference in the diagnostic sensitivity of both diagnostic methods is not significant (p greater than 0,05). The calcifications in pancreas are better detected by computer tomography whereas both methods are equivalent in the diagnosis of the pancreatic cystes. In carcinoma of pancreas computer tomography gives the correct diagnosis of the disease (p greater than 0,05) in 69,5 per cent and echography--in 78,8 per cent of the patients. With computer tomography false negative results amount to 30,5%; in 13,9 per cent normal pancreas was described and in 16 per cent--pseudocyst in pancreas. With echography--false negative results were established in 21,2 per cent of the patients; 12,1 per cent chronic pancreatitis was described, in 9,1 per cent--pseudocyst in pancreas but, at the same time, pancreas was not properly visualized in 8,3 per cent of the examined. Making use of both methods, accurate diagnosis was made in 83,3 per cent of the patients with carcinoma of pancreas.

Carcinoma↗
PubMed1983

[Treatment of duodenal ulcer with biomet].

The results are reported from the treatment of 30 patients with the Bulgarian preparation biomet, which is a blocker of histamine H2-receptors. The treatment lasted 20 days with 3 X 20 mg biomet, after meals, and 400 mg in the evening before going to bed. Pains disappeared in 86,6 per cent with biomet treatment, pyrosis--in 95,8 per cent, eructation--in 95,3 per cent, nausea--in 84,7 per cent, vomiting--in 100 per cent of the patients, etc. (the clinical symptoms completely disappeared in 76,7 per cent after the treatment and were substantially reduced in 16,7 per cent). A statistically significant reduction of the basic parameters of gastric secretion and acid output occurred after biomet treatment as compared with the initial values. The fibroendoscopic study of the duodenal ulcer, after the treatment, revealed a complete epithelization in 52 per cent and diminished ulcer size--in 44 per cent. No pronounced adverse effects were observed during biomet treatment. The Bulgarian preparation biomet is fully equivalent to the English Cimetidine (the latter being more expensive) and should find a broad application in the treatment of duodenal ulcer.

Adult↗
PubMed1983

[Treatment of peptic ulcer with Alcid V].

The results from Alcid V treatment are reported, carried out in the course of 20 days on 39 patients with duodenal and 20 patients with gastric ulcers. A group of 20 patients with duodenal and 10 with gastric ulcers, treated with placebo served as a control under the conditions of double-blind experiment. The pains completely abated in 84 per cent of the patients with gastric ulcer, the pyrosis in 100 per cent, eructation--in 92.3 per cent and the ulcer--in 68.42 per cent, and in the patients with duodenal ulcers--76.9 per cent, 93.10 per cent, 94.3 per cent and 40.62 per cent respectively. As regards the clinical symptoms of gastric ulcers, very good effect was obtained in 76 per cent and good effect--in 24 per cent; in the cases with duodenal ulcers--70.49 per cent and 15.38 per cent respectively. The discrepancy between the effect on the clinical symptoms and on the ulcers (the changes of the latter being endoscopically determined) between the Alcid V treated patients and the control group with placebo are statistically significant. In both groups the gastric secretion (determined by pentagastrin test) is not substantially changed as compared with the values prior to the treatment. Alcid V in the dose administered and the duration of the treatment induced no adverse effects and no essential changes in the biochemical indices; it was well tolerated and could find its application in the treatment of ulcer disease.

Anti-Ulcer Agents↗
PubMed1983

[Clinical trial of the preparation Verbascan in treating gastrointestinal and biliary diseases].

The therapeutic results are presented from the peroral administration of the new Bulgarian preparation Verbascan (spasmolytic, cholinolytic and analgesic), 10 mg three times daily, to 50 patients: with duodenal ulcer--20, with cholelithiasis 10 and dyskinesia of biliary ducts and colon--10 each. In case of duodenal ulcer, the clinical symptoms were very well influenced after 20-day treatment in 65.5 per cent, well in 15.1 per cent, poorly--in 12.5 per cent and without effect in 12.5 per cent and the ulcer faded in 50 per cent, considerably reduced in size in 20 per cent and with no change--20 per cent of the treated (the effect on the ulcer was better, with statistical significance, as compared with the control placebo group). Gastric secretion was not substantially changed by the treatment carried out. The pain and dyspeptic complaints in cholelithiasis were favourably affected in 60 per cent of the treated but the peroral intake did not cope the cholelithiasis crises, rapidly and effectively. Verbascan eliminated and reduced the pains in half of the patients with dyskinesia of biliary ducts and colon, but it had no effect in the pains in the other halt. Verbascan was well tolerated, with no adverse effects, with a favourable ulceroprotective effect, hence it could be used in the treatment of the duodenal ulcer, cholelithiasis and dyskinesia of the biliary ducts and colon with moderate pains.

Alkaloids↗
PubMed1981

[Pancreatic exocrine secretion in chronic alcoholism].

Pancreas exocrine secretion in 45 patients with chronic alcoholism was studied. Pancreocimene-secretion test was carried out in all of them, with the determination of pancreas secretion, concentration of bicarbonate excreted, amount of the secreted bicarbonates and a total quantity of the secreted diastase and lipase. Serum provocative test was carried out in parallel. The results were compared with the control group of 30 healthy subjects. Disturbed pancreas secretion was found in 57,7 per cent of the subjects examined, the volume of secretion being reduced in 37,7 per cent of the patients, bicarbonate secretion--in 44 percent; amount of secreted bicarbonates--in 51,1 per cent, quantity of secreted lipase--in 57,7 per cent and diastase--in 51,1 per cent of the patients. The discrepancies with the control group are statistically significant. In 42,2 per cent of the examined--positive provocative test was established. Hypersecretion of liquids and bicarbonates was found in 13,3 per cent of the patients. The severity of the changes in pancreas secretion depends on the amount and duration of alcohol consumption.

Adult↗
PubMed1981

[Changes in salivary secretion in pancreatic patients].

Saliva secretion was studied via pilocarpine test in 40 patients with pancreas exocrine insufficiency: 32 patients with chronic pancreatitis and 8 patients with pancreas carcinoma. After pilocarpine stimulation, the volume of saliva secretion was determined in ml., as well the concentration and quantity of the secreted bicarbonates, amylase and protein. The results were compared with a control group of 17 healthy subjects. Statistically significant diminution of all indices of saliva secretion was found in the patients with pancreas exocrine insufficiency (p less than 0.001). The correlation relationship between the changes of pancreas and saliva secretion was studied. Saliva secretion could be used as orientating test for the presence of pancreas exocrine insufficiency.

Cholecystokinin↗
PubMed1979

[Comparative functional, scintigraphic and angiographic studies in pancreatic diseases].

Pancreas scintigraphy with 75selenomethionine, pancreocimine-secretin test and selective abdominal angiography was carried out in patients with chronic pancreatitis, pancreas carcinoma and subjects without any pancreas diseases. Scintigraphic changes in pancreas were found in 95.6 per cent of the patients with chronic pancreatitis (136 patients) in 92 per cent of them with pancreas carcinoma (25 patients) and in 53.4 per cent from the subjects without pancreas diseases (30 examined). Pathological changes in pancreatic secretion was found in 93.4 per cent of the patients with chronic pancreatitis (105 patients) in 93.8 per cent of the subjects with pancreas carcinoma (32 patients) and only in 3.3 per cent from the examined without pancreatic diseases. The angiographic examination is informative mainly in case of tumours and cysts of the pancreas. The diagnostic potentialities of the separate methods for pancreas examination were critically assessed. The basic diagnostic problems, in pancreas diseases are solved to a great extent with the combined examination with scintigraphy, pancreocimine-secretin test and angiography (76 patients).

Angiography↗
PubMed1979

[Effect of alcohol on pancreatic exocrine secretion].

Pancreas exocrine secretion was studied in 10 patients viapancreocymine-secretin test, determining the volume of pancreatic secretion, concentration and quantity of the secreted bicarbonate and total quantity of secreted pancreas amylase and lipase. Acute effect of alcohol was studied in the same patients and two-three days after the first determination of pancreatic secretion, a second pancreocymine-secretin test was performed, with 150 ml 40 per cent alcohol being introduced into the stomach prior to pancreocymine stimulation. The results prior to and post alcohol loading were compared in each patient. A statistically significant inhibition of pancreas bicarbonate and enzime secretion developed under the effect of alcohol. The probable pathogenetic mechanisms of alcohol effect upon pancreas are discussed.

Adult↗
PubMed1978

[Pancreatic exocrine secretion in cancer of the pancreas].

Pancreatic exocrine secretion was studied in 22 patients with pancreas cancer. In 17 of patients the diagnosis was made at operation. In all patients examined the pancreocymine-secretin test according to Herfort was performed. The results were compared with those of a control group of 30 healthy subjects. In 95.5 per cent of the examined a statistically significant decreased hydrobicabonate and enzyme secretion was found. The changes in the pancreatic secretion are characterized by the presence of a total secretory deficiency, with a significant diminution ( p less than 0.001) of all parameters of pancreatic secretion.

Carcinoma↗
PubMed1976

[Chronic recurrent pancreatitis with erosive gastritis in a patient with primary hyperparathyroidism].

A female with premary hyperparathyroidism and secondary renal lesions, as well as lesions of the stomach and pancreas is described. The initial illness was manifested by repeated renal crises. Later, gastroenterological complaints appeared--epigastralgia, vomiting, frequent hematemesis with melena. That was the cause for a gastric resection, diffuse erosive gastritis being found. After the operation, the pains and the vomiting of hematin matter repeatedly recidivated. Clinically and at the laboratory, data were formed for a chronic recidivating pancreatitis with the presence of primary hyperparathyroidism. The postoperative treatment of the parathyroid adenoma led to an improvement of the gastroenterological complaints.

Adenoma↗