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Biomedical subjects

A Melman

Publications and source records attributed to A Melman.

126 records · Page 7Linked to original sources
PubMed1979

Nonhomologous associations of C-heterochromatin at human male meitoic prophase.

In human male meiotic prophase, nonhomologous pairings and connections between C-heterochromatic regions were demonstrated by C-banding and G-11 staining. Approximately 40% of the pachytene stages exhibited bivalent associations at regions of C-heterochromatin. Nonhomologous associations were seen between all possible morphological types of bivalents. Evidence is submitted suggesting that nonhomologous associations between regions of C-heterochromatin are a fairly common event in many organisms, including man, and the possible roles of this phenomenon in meiosis are discussed.

Azure Stains↗
PubMed1978

Nonassociation of hyperamylasemia and prostatic disease.

The possible correlation of hyperamylasemia and prostatic disease was investigated in patients with benign prostatic hyperplasia, adenocarcinoma of the prostate, and in patients without clinical evidence of prostatic lesion. Our results indicate that prostatic lesions whether benign or malignant are not associated with either elevation of serum amylase or abnormal isozyme zymograms.

Adenocarcinoma↗
PubMed1978

Evaluation of the dermal graft inlay technique for the surgical treatment of Peyronie's disease.

The results of treatment with the dermal graft inlay technique for 7 patients with Peyronie's disease and the inability to achieve intercourse are discussed. All 7 patients were unable to attain tumescence postoperatively. We believe that patients who require surgical therapy for Peyronie's disease and who have functional impotence should be treated with silicone penile implants.

Adult↗
PubMed1978

Bilateral renal loss resulting from intravesical formalin instillation.

A patient was referred for evaluation of obstructive uropathy after treatment with 10% formalin to control recurrent hemorrhagic radiation cystitis. Progressive bilateral ureteral, pelvic, and renal parenchymal destruction occurred despite ileal ureteral replacement. This complication of therapy reinforces the concept that vesical instillation of formalin should be done only in extreme cases and then only in low concentrations.

Female↗
PubMed1977

Increased incidence of renal cell carcinoma with hypertension.

Of 276 patients who underwent evaluation to determine the cause of hypertension 2 were found to have unsuspected renal cell carcinoma. This prevalence of 0.73 per cent is 16 times higher than expected for an age-matched population. Both patients exhibited abnormalities of plasma renin activity before radical nephrectomy but they remained hypertensive postoperatively. The data suggest an unexplained association between hypertension and renal cell carcinoma. Furthermore, abnormalities on excretory urograms in hypertensive people should be defined by selective renal arteriography.

Adenocarcinoma↗
PubMed1977

Improved diagnostic accuracy of renal venous renin ratios with stimulation of renin release.

Fifty patients who underwent renal angiography and bilateral renal venous determinations had reconstructive or ablative surgery. The importance of stimulating renin release was underlined in 11 patients who attained a renal venous ratio greater than 1.5 to 1 only after being in an upright posture and in 5 who were studied with and without salt depletion. A protocol designed to suppress or stimulate peripheral plasma renin activity was followed in 19 patients. Stimulated peripheral plasma renin activity was not useful in identifying hypertension of renovascular origin but 10 of 12 patients whose plasma renin activity was not suppressed normally were improved by an operation. Satisfactory surgical responses were obtained in 81 per cent of the patients with unilateral and 91 per cent with bilateral atherosclerosis, and 88 per cent with unilateral and 60 per cent with bilateral fibromuscular hyperplasia. Our observations indicate that renal artery stenosis can be identified consistently only by angiography. A stimulated renal venous renin rate of 1.5 to 1 appears to have the best predictive value in surgical control of renovascular hypertension.

Adolescent↗
PubMed1977

Role of renal vasodilatation in the blunted natriuresis of saline infusion of dogs with chronic bile duct obstruction.

Since part of the natriuresis of the extracellular fluid volume expansion (ECVE) is due to renal vasodilatation, it is possible that the blunted natriuresis during ECVE in dogs with chronic ligation of common bile duct (CBD) is due to gailure to renal arteries to dilate. Studies were carried out to investigate this question in normal dogs, sham-operated animals, and dogs with acute and chronic legation of CBD. ECVE with 0.45 percent saline caused a significant rise in renal plasma flow (RPF) and urinary sodium excretion (UNaV) in all animals except those with chronic ligation of CBD. In the latter dogs, the increment in UNaV was significantly less than that observed in the other groups of animals, and RPF did not increase significantly following saline infusion in dogs with CBD ligation. The intrarenal administration of acetylcholine produced a significant and comparable increase in RPF in all animals, including those with chronic ligation of CBS, but the rise in UNaV in the latter was significantly less than that in the other groups of dogs. The data indicated that (1) ECVE is not associated with renal vasodilatation in dogs with chronic ligation of CBD, (2) this abnormality is not due to a defect of the renal arteries to respond to vasodilators, and (3) the lack of renal vasodilatation may be partly responsible for the blunted natriuresis, but other sodium-retaining forces may also be operative.

Acetylcholine↗
PubMed1976

Experience with implantation of the Small-Carrion penile implant for organic impotence.

The 13 patients described herein have had successful placement of a Small-Carrion penile prosthesis through a penile incision. Because of surgical control and possible decreased chance of infection this approach is advocated over the perineal incision except in cases of post-priapism impotence or simultaneous placement of a Kaufman anti-incontinence device.

Doxycycline↗
PubMedDate not supplied

Effects of age, menopause, and comorbidities on neurological function of the female genitalia.

The aim of this study was to investigate the effects of age, menopause, and comorbidities on neurological function of the female genitalia using a noninvasive, validated technique. In all, 58 consecutive women were enrolled in the study. Biothesiometry was performed at five genital sites and one peripheral site with S2 dermatome distribution. Kruskal-Wallis one-way ANOVA on ranks was used to evaluate the relationship between age and vibratory sensation. Bivariate and regressional analyses were performed to evaluate the effects of age, menopause and comorbidities on genital sensation. The mean age was 44.6+14.8 y (range 20-78 y). Vibration thresholds increased with advancing age at all six sites. Multilinear regression analysis indicated that menopause and increasing age negatively affect sensation. History of herniated lumbar disc, vaginal delivery, and diabetes variably affected genital sensation. There is a significant increase in vibration thresholds (indicating worsening neurological function) in women as they age and undergo menopause. Biothesiometry is a technique for evaluating genital neurological function in women with coexisting morbidities.

Adult↗
PubMedDate not supplied

Cutaneous temperature measurements in men with penile prostheses: a comparison study.

To evaluate and compare the cutaneous temperature of the penis in normal men, those with erectile dysfunction (ED), those with semirigid penile prostheses (SRPPs), and those with inflatable penile prostheses (IPPs), and those before and after trimix injection to create a penile erection. A total of 68 patients were evaluated. Five patient groups were identified, including men with normal erectile function, with ED, with SRPPs, with IPPs, and following intracavernosal injection of trimix solution. Cutaneous glans temperature increased significantly by more than 2.2 degrees C in the trimix-injected group compared with all other groups (P<0.001). Using cutaneous temperature measurements of the penis, patients with SRPPs had significantly lower cutaneous glans temperatures than normals (P<0.02), those in the ED group (P<0.04), and those in the IPP-deflated group (P<0.01). The mean temperature difference was 1.44+/-0.40 degrees C. Using cutaneous temperature measurements of the penis, men with SRPPs have a colder glans as compared with men with normal erectile function, ED, IPPs, and those who have received an injection of trimix. Men with normal erectile function, ED, and IPPs did not have significant cutaneous temperature differences.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

Can self-administered questionnaires supplant objective testing of erectile function? A comparison between the International Index Of Erectile Function and objective studies.

To determine whether the results of the self-reported International Index of Erectile Function (IIEF) to assess erectile function can overestimate the degree of erectile impairment. A total of 32 consecutive patients seeking treatment for erectile dysfunction (ED) at a urologist's office were evaluated by completion of the erectile function domain of the IIEF. Nocturnal penile tumescence testing using the Rigiscan (Timm Medical Technologies Inc., USA) was performed in these patients after completion of the IIEF. The median IIEF-6 score was 9 of 30 (range, 1-25; mean, 11/30). Rigiscan results were abnormal in six patients (19%), normal in 25 patients (78%), and unable to interpret in one patient (3%). IIEF-6 scores were subdivided by severity along with Rigiscan results. There was no correlation between age, IIEF score, or Rigiscan results. In conclusion, the IIEF is a useful tool and is helpful for follow-up of a patient to evaluate efficacy of treatments for ED, but should not replace objective testing to diagnose the quality of ED.

Adult↗
PubMedDate not supplied

Gene transfer for the therapy of erectile dysfunction: progress in the 21st century.

Gene transfer represents the next potential era of advancement in medicine for the prevention of the effects of aging or for treatment of genetic or acquired disease. For gene transfer to be a practical successor to today's oral and minimally invasive therapies, the product must have a high safety profile and a long duration of effectiveness to correct the need for on-demand administration. Several types of vectors have been used in preclinicals studies, but because of widely publicized adverse events, progress using viral vectors in humans has been limited. There is a current phase I human trial using naked DNA as the vector with the maxi-K gene to modify cellular contractility. Preliminary results in the safety trial thus far have shown no treatment-related adverse events, no transfer to the semen, and the possibility of efficacy in one participant.

Animals↗
PubMedDate not supplied

[Detailed evaluation of sexual function after radical prostatectomy: is patient satisfaction correlated with the quality of erections?].

INTRODUCTION: Post radical prostatectomy potency rates, quantified on the basis of physician survey, have ranged up to 80%. Physician derived potency data, however, may not be representative of true post-prostatectomy potency rates or more importantly may not accurately portray patients' post-operative sexual satisfaction. We conducted a pilot study combining physician derived and patient derived subjective data with objective measures of erectile function. MATERIALS AND METHODS: Eleven men, mean age of 59 years, who were treated with nerve sparing radical retropubic prostatectomy formed the study group. Initially, the patients responded to a physician directed telephone survey on sexual status. Potency was then objectively assessed utilizing Rigiscan testing on two consecutive evenings. Lastly, the patients completed a validated short questionnaire directed to obtain a patients' subjective perception of sexual function. RESULTS: All the patients responded to the first part of the study by informing the physician that they were sexually active or potent after radical prostatectomy. Of these 11 patients, however, only 2 (18%) were mostly satisfied with their sex life according to the quality of life questionnaire. Rigiscan testing revealed that 8 of the 11 patients had nocturnal erections which were adequate for vaginal penetration. Of the 5 patients who stated that they were mostly dissatisfied with their sexual functioning, 3 had objective evidence of adequate erectile ability as documented by Rigiscan. Three of the four patients who were ambivalent with respect to their sexual function also demonstrated objective evidence of normal erectile activity. CONCLUSION: Although a patient may inform his care provider that he is sexually active or potent, he may not be satisfied with his present level of sexual functioning. In addition, we observed that some dissatisfied patients do have normal Rigiscan patterns indicating that a percentage of patients who are not happy with their level of sexual function after radical prostatectomy may have a psychogenic component to their problem.

Aged↗