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Biomedical subjects

A Mehregan

Publications and source records attributed to A Mehregan.

4 recordsLinked to original sources

Papular mucinosis.

Most patients previously reported to have papular mucinosis had the generalized lichenoid papular form (scleromyxedema) with abnormal gamma globulin. Microscopic examination of affected skin showed increased acid mucopolysaccharides in the dermis and proliferation of fibroblasts. Our patient had the discrete form of papular mucinosis without abnormal serum gamma globulin but with increased amounts of acid mucopolysaccharides in the dermis and no proliferation of fibroblasts.

Adult

Trichoadenoma of Nikolowski.

Trichoadenoma of Nikolowski is a rare benign tumor of the skin with hair follicle-like direction of differentiation. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma. Probably because of its rarity it has not been a well recognized tumor. We are reporting on eight cases of trichoadenoma to further define this benign growth.

Adenoma

Bowen disease associated with porokeratosis of Mibelli.

A 73-year-old woman developed Bowen precancerous dermatosis in an area of porokeratosis of Mibelli on her leg. This is the fourth reported case of Bowen disease arising from porokeratosis of Mibelli. The recent literature indicates that porokeratosis of Mibelli may be due to an abnormal clone of cells, predisposing affected individuals to development of malignant neoplasms over the involved areas.

Aged

Hairy cutaneous malformations of palms and soles. A hereditary condition.

Hairy cutaneous malformations of the palms and soles were observed in four generations of a French-Canadian family. The lesions were asymptomatic, bilaterally symmetrical, and involved small areas of skin of the central proximal part of the palms near the wrist and the medial aspect of the longitudinal arch of the foot. The appearance suggested a difference in quality of the skin rather than simply the presence of hair follicles. Examination of a biopsy specimen showed skin containing hair follicles. The pattern of inheritance was autosomal dominant with definate male-to-male transmission. Genetic linkage studies were generally noninformative, but evidence was obtained against close chromosomal linkage of this trait to the histocompatibility antigen (HL-A) or Rh blood group locus. The only other known case of a familiar condition was reported by Schnitzler in 1973.

Biopsy