Biomedical subjects
Publications and source records attributed to A Medford.
Pleural disease remains a commonly encountered clinical problem for both general physicians and chest specialists. This review focuses on the investigation of undiagnosed pleural effusions and the management of malignant and parapneumonic effusions. New developments in this area are also discussed at the end of the review. It aims to be evidence based together with some practical suggestions for practising clinicians.
A line abutting two tilted flanks is apparently shifted towards the orientation orthogonal to the flanks and at the same time is reduced in its apparent length. It has been suggested that both effects are caused by band-pass spatial filtering, followed by location of the end points of the line at the peaks in the filtered image. Here implications of the filtering explanation of these effects are explored further. In the first experiment, it was predicted that orientation thresholds (as opposed to biases) would be increased for short line lengths, and would be further increased by abutting bars. The predictions were confirmed. It was shown in experiment 2 that the orientation shift was reduced by a small (4 min arc) gap between target lines and orthogonal flanks. In experiment 3 the threshold elevations and the orientation shift produced by orthogonal and tilted flanks were compared. Last, in experiment 4, the threshold elevations and orientation shift produced by orthogonal and tilted flanks, at different retinal eccentricities varying from 0 to 3.2 deg were compared, and the prediction that the magnitude of the orientation shift would decrease with line length and increase with eccentricity was confirmed. The connection is explored between the orientation shift and the Zöllner illusion, and demonstrations are presented of the Zöllner effect in which target and inducing lines are of opposite contrast on a gray background. It is concluded that the Judd and Zöllner illusions do not depend upon a single mechanism.
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Ro 21-7634 was examined for oral antiallergic activity in two in vivo models commonly used to evaluate antiallergics. In the rat PCA test, this drug had an oral ID50 of 1.14 mg/kg and was found to be more potent than several other antiallergics including Disodium Cromoglycate (cromoglycate), Oxatomide, Doxanthrazole, Xanoxate, 2,6-bis (ethyoxyoxalylamino) pyridine, PRD-92-EA and M + B 22,948. In contrast to cromoglycate, Ro 21-7634 was found to be an orally active inhibitor of antigen-induced broncho-constriction in passively sensitized rats (ID50 = 0.2 mg/kg). In addition, Ro 21-7634 inhibited antigen-induced histamine release in an in vivo passive peritoneal anaphylaxis test system, following intraperitoneal administration. Ro 21-7634 demonstrated no end organ antagonism toward histamine, metacholine or serotonin in the guinea pig.