Normoglycaemic ketoacidosis in a woman with gestational diabetes.
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Adult↗
Biomedical subjects
A McConnell
Publications and source records attributed to A McConnell.
Effects of lateral ball location, grade, and sex on catching.
To investigate the effects of lateral movement on the quality and quantity of catching as they interact with age, 108 children from Kindergarten through Grade 4 were tested. A ramp was constructed which slowed the descent of the 4-in. fleece ball so that it took 1.8 sec. to arrive at the child's location. Each ball could be delivered to one of five different locations in relation to the child. The child practiced five times, with balls coming in a random sequence to each location, the center of the ramp, 1 ft. and 2 ft. each to the right and left of the center. An increase in number of catches made and in the quality of the performance based on McClenaghan and Gallahue's evaluation were associated with grade. The locations 2 ft. from the center produced the fewest catches within a grade, but 1 ft. from center produced more catches from kindergarteners than the center location and occasionally for upper grades. Evaluations of the performances showed a steady improvement across grades, but there was no effect on the evaluation of catching performance of ball location within a grade. Children appear to be at a preferred stage.
Attention↗
Underdiagnosis of psychoactive-substance-induced organic mental disorders in emergency psychiatry.
The tendency of emergency psychiatrists to make alcohol- and drug-related diagnoses was examined before and after the addition of a standardized psychoactive substance use questionnaire. The addition of the questionnaire resulted in a significant increase in the number of psychoactive-substance-induced organic mental disorder (substance-induced disorder) diagnoses. The questionnaire selectively increased the recognition of nonalcoholic substance-induced disorders while not significantly increasing the diagnoses of alcohol-induced disorders when alcohol was used alone. This suggests that nonalcoholic substance-induced disorders are underdiagnosed in emergency psychiatry. With the increase in the diagnoses of substance-induced disorders, there was a significant decrease in the frequency of psychotic disorder diagnoses and a significant increase in the frequency of adjustment disorder diagnoses. The clinical impact of underdiagnosing and misdiagnosing substance-induced disorders is discussed. Overall, the findings suggest that an increased awareness of substance use history, by the use of a standardized questionnaire, is an effective means of increasing the diagnostic yield of substance-induced disorders in the psychiatric emergency room. Follow-up studies using urine drug screening are recommended.
Diagnosis, Differential↗
Inactive renin--a renin proenzyme?
Human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. After acidification to pH 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin. In human kidney extracts, an increase in renin concentration also occurred after acidification. The inactive form of renin may be similar to that of rabbit kidneys, which contain an inactive renin that can be activated by removal of an acid-labile inhibitor. The question as to whether the inactive material is a renin proenzyme is discussed.
Animals↗
An inactive renin in human plasma.
Normal human plasma contains an active form of renin that is activated by acidification to pH 3.0 and comprises 56% of the total renin. In our study, inactive renin was also present in plasma from five anephric persons, and the proportion of active to inactive renin in these subjects was similar to normal. Plasma from normal pregnant women contained increased concentrations of inactive renin and the proportion of inactive renin was raised to around 66%. Plasma from persons with renal hypertension contained varying amounts of inactive renin but the mean percentage (35%) was lower than normal. An infusion of saralasin sufficient to lower the blood pressure in five subjects with renal hypertension resulted in a rise in active renin concentration but no change in the concentration of inactive renin. Plasma angiotensin II correlated with active renin but not with inactive renin, suggesting that the inactive renin does not produce angiotensin II in vivo.
Angiotensin II↗
Inactive renin in human plasma.
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Angiotensin II↗
Effect of knowledge of results on attitude formed toward a motor learning task.
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Attitude↗
A renin inhibitor from rabbit kidney: conversion of a large inactive renin to a smaller active enzyme.
Renin in extracts of frozen rabbit kidney exists in two forms: active (molecular weight about 37,000) and inactive (molecular weight about 55,000) renin. The inactive form becomes active after exposure to pH 2.5 at 4 degrees C. If extracts are chromatographed on DEAE cellulose, the inactive renin dissociates into active renin plus a renin inhibitor (molecular weight about 13,000). The inhibitor recombines with active renin if the two are incubated together at 37 degrees C. The inhibitor is destroyed by acid treatment at pH 2.5 at 4 degrees C. We conclude that the activation of inactive renin is due to destruction of the inhibitor by acid. The inactive material may be a renin proenzyme or a storage form of active renin combined with inhibitor.
Animals↗
Proceedings: Activation of renin in human plasma and in rabbit kidney extracts.
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Animals↗