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Biomedical subjects

A Mazzoni

Publications and source records attributed to A Mazzoni.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Anatomicopathological findings relating to fungal infections: considerations on their increase and microbiological findings].

2,366 consecutive autopsies carried out at the Institute of Anatomy and Histopathology of the University of Genova over the last 10 years are re-examined. 33 cases of visceral mycosis were found (a frequency of 1.4%). The following factors were considered: number and location of fungal infection, morphological characteristics of mycetes responsible, host tissue reaction, relationship with any other disease manifestation or predisposing factors. It is emphasized that these infections are increasing in frequency and severity. Clinics should therefore always consider possible fungal causes in the differential diagnosis of infections.

Adolescent↗
PubMed1985

Limits of antifungal prophylaxis by ketoconazole in leukemic patients.

Serum ketoconazole levels in leukemic patients, subjected to ketoconazole prophylaxis, were determined by an agar diffusion assay. High individual variability of drug concentration was noted. In addition, the highest drug concentration observed was less than 1 microgram/ml in 5 out of 6 patients studied. The reliability of prophylaxis of airborne opportunistic fungal infections by ketoconazole seems, therefore, to be hampered, at least in leukemics, by the too low serum concentrations of the drug. The bioassay proved to be highly reproducible and accurate as well as easy and safe to perform.

Adult↗
PubMed1984

Effect of medroxyprogesterone acetate and of some antiinflammatory agents on mouse erythroleukemia cell differentiation.

The effects of medroxyprogesterone acetate (MPA) on differentiation were examined using mouse erythroleukemia (MEL) cells and compared with those of antiinflammatory agents. MPA at low doses (10(-6) - 10(-7)M) induced 10-15% cells to differentiate, whereas high doses (10(-4) - 10(-5)M) caused a 30% inhibition of dimethylsulfoxide (DMSO)-induced differentiation. Dexamethasone (10(-4) - 10(-8)M), a steroid antiinflammatory agent, significantly inhibited (77-70%) DMSO-induced differentiation, whereas indomethacin, aspirin, flurbiprofen and BW755c (non steroid antiinflammatory agents) at the same concentrations had no effect. If added 24 h before DMSO, the inhibitory effects of MPA and dexamethasone increased to 65% and 95%, respectively, whereas indomethacin (10(-5)M) caused only a 30% inhibition and the other drugs were inactive. None of these antiinflammatory agents affected differentiation when used without DMSO. MPA and dexamethasone inhibitory effects on DMSO-induced differentiation did not seem to be mediated through the inhibition of the synthesis of prostaglandins, since non-steroid prostaglandin inhibitors were slightly active only when added 24 h before DMSO.

4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyraz↗
PubMed1984

Hemodiafiltration (HD-HF): one year follow-up of nine hours weekly.

Data are presented concerning our experience with hemodiafiltration (HD-HF) in uremic patients. Ten patients previously submitted to regular dialysis treatment, cuprophane membrane (RDT), for the last year twelve hours weekly, were treated for one year, nine hours weekly, HD-HF. Five of ten had suffered discomfort by RDT and five spontaneously chose HD-HF owing to its shorter treatment period. The follow-up of the two treatment schedules did not show any significant difference in absolute and percentage values of small molecules. Hematocrit, body weight and blood arterial pressure were not different following both treatment. Patients submitted to HD-HF complained of no discomfort including patients suffering of dialytic discomfort under RDT. HD-HF has proved as useful and more comfortable than RDT in long-term treatment of patients with chronic renal failure.

Adult↗
PubMed1980

Transnasal microsurgical ethmoidectomy in nasal polyposis.

A technique of microsurgical ethmoidectomy by a nasal route was devised for and applied to the treatment of nasal polyposis. A description of the operative procedure and the results in 30 cases with a 3-5 years of follow-up are reported.

Adult↗
PubMed1979

[The venous drainage of the vestibular labyrinth in man (author's transl)].

The venous drainage of the vestibular division of the inner ear presents two different and separated routes. One, draining the central part of the sensorial areas (maculae and cristae), ends up into the vein of the cochlear aqueduct. The other drains the perypheral part of the sensorial areas as well as the simple endolymphatic walls and ends into the vein of the vestibular aqueduct. The latter vein shows close relationships to the endolymphatic sac.

Cochlea↗
PubMed1976

Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia.

Sera from 1,279 patients with various diseases were examined for the presence of antibodies to BK virus (BKV) capsid antigens. The percentage of positive sera was comparable in all the diseases except rheumatoid arthritis and chronic nephropathies, where a slightly higher prevalence was found. Sera from 952 patients with tumors were examined for the presence of antibodies to BKV tumor and capsid antigens in comparison with a matched control group of 501 blood donors. Sera from 11 tumor patients (1.15%) and from 4 normal controls (0.80%) had antibodies to BKV tumor antigen. No higher prevalence of antibodies to BKV capsid antigens was found in any cancer type except in carcinomas of the urinary bladder, where the percentage of positive sera and of sera with high titers was higher than in other groups. BKV infection is discussed in relation to its possible connection with human non-neoplastic diseases as well as with human tumors and to its activation under conditions of immunosuppressive therapy.

Antibodies, Viral↗