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Biomedical subjects

A Mayer

Publications and source records attributed to A Mayer.

At least 217 records · Page 12Linked to original sources
PubMed1975

On the pH-dependence of the reaction of hemoglobin with carbon monoxide.

Flash-photolysis experiments were performed on solutions of carbonmonoxy hemoglobin (human Hb A) as function as pH. The fraction of fast reaction and the amount of photodissociation as produced by a given amount of light quanta has been analyzed in terms of the allosteric model of ligand binding by Monod, Wyman and Changeux. It is shown how the switch-over point of the allosteric transition from the T or R state is controlled by the protons, which act as allosteric effectors.

Carbon Monoxide↗
PubMed1975

Acid treatment of Drosophila deoxyribonucleic acid.

In cytologic preparations of chromosomes, acid-treated deoxyribonucleic acid (DNA) is found largely in the native state. However, acid treatments widely used for chromosome preparations produce significant amounts of depurination in DNA. DNA is similarly sensitive to depurination in intact cells or as purified DNA. If treated with alkali, these apurinic gaps can be converted to single strand breaks. Acid treatment has widely different effects on specific fractions of DNA. In Drosophila melanogaster 3% of the DNA is composed of very long tracts of pyrimidines (polypyrimidines) which are resistant to acid hydrolysis. The implications of these results for molecular cytogenetics are discussed.

Acetates↗