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Biomedical subjects

A Matsuo

Publications and source records attributed to A Matsuo.

At least 109 records · Page 6Linked to original sources
PubMed1986

Mechanical efficiency in rowing.

Five university oarsmen participated in a determination of mechanical efficiency when rowing in a tank. In the tank, water was circulated at 3 m X s-1 by a motor driven pump. The subjects rowed with the stepwise incremental loading, in which the intensity increased by 10% of the maximum force of rowing (maxFc) every 2 min. Power (WO) was calculated from the force applied to the oarlock pin (FC) and its angular displacement (theta H). Oxygen uptake and heart rate were measured every 30 s during rowing. Anaerobic threshold (AT) was determined from expired gas variables by Wasserman's method. AT of oarsmen was 74.6 +/- 6.01% as a percentage of VO2max. As the displacement of the handgrip in the stroke was independent of WO, the increment of WO was caused by the increase of both FC and stroke frequency. Gross efficiency without base-line correction (GE) increased with FC with low intensities of rowing. In the region of 124-182 W of WO GE was almost constant at 17.5%. Efficiency was 19.8 +/- 1.4%, with resting metabolism as base-line correction (net efficiency), and 27.5 +/- 2.9% when using the unloaded rowing as the base-line correction (work efficiency), and 22.8 +/- 2.2% when calculating the work rate as the base-line correction (delta efficiency).

Adult↗
PubMed1986

Litter parameters and spontaneous abnormalities in Himalayan rabbits.

A joint study was undertaken in three testing facilities to evaluate cumulative background data of Himalayan rabbits. All litters were derived from control does. The conception rate was high (84.0-95.1%) but the average numbers of corpora lutea (7.9-8.7), implantation sites (6.5-7.5) and viable fetuses (5.8-6.9) were somewhat lower than that of most other strains of rabbit. Altogether 90 malformed fetuses (1.12%) and 425 fetuses with variations (5.27%) occurred among 8,060 virable fetuses.

Animals↗
PubMed1982

Teratology study with orciprenaline sulfate in rabbits.

Orciprenaline sulfate (Alupent), a beta-adrenoceptor stimulant, was studied for adverse effects on pregnant rabbits and their fetuses. Himalayan rabbits (Kawanishi) were dosed orally at 0 (control), 5, 25 and 50 mg/kg/d from gestation day 6 through 18. 15 does were used per group. No distinct influences of orciprenaline sulfate on litter parameters and no teratogenic effect was observed including the "maximum tolerated dose" of 50 mg/kg.

Animals↗
PubMed1982

The preventive effect of human interferon-alpha on influenza infection; modification of clinical manifestations of influenza in children in a closed community.

A double-blind, controlled trial to ascertain the preventive effect of human interferon-alpha (Hu IFN-alpha) on upper respiratory viral infections was performed on children in a closed community. Drops of Hu IFN-alpha were instilled into the nasal cavity of 13 healthy children aged one to three years. Fourteen children were given placebos as controls. Administration of the interferon and clinical observations were carried out in the winter of 1980. Serological examination revealed that this was the period of outbreaks of influenza type A epidemics in the community. Clinical manifestations referable to influenza virus infection were milder in the interferon-treated group than in the controls. However, there was no significant difference in the serological responses of the two groups after infection with influenza virus type A.

Administration, Intranasal↗
PubMed1981

Identification of substrain of Himalayan rabbits produced in Japan.

The Himalayan rabbit, Chbb : HM has been bred in Kawanishi for about 10 years. The advantage of this strain of rabbit is its mature body-weight of 2.0--2.2kg. In our labs the following parameters of the Himalayan rabbit have been observed : Conception rate 96%, miscarriages 2.7%, viable offspring 6.1 +/- 2/litter, weaning rate 77--92% and malformation rate 1.3%.

Animals↗
PubMed1980

Effect of human leukocyte interferon on the metastatic lung tumor of osteosarcoma: case reports.

Three patients with pulmonary metastases of osteosarcoma underwent treatment with intravenous or intramuscular administration of human leukocyte interferon. In 2 cases, the size of the metastasized tumor mass diminished temporarily six or eight months after interferon treatment, and serum alkaline phosphatase levels decreased to normal. In 1 case, the tumor cell from the pleural exudate 1 could be isolated and cultivated in vitro. When 2,000 IU of interferon was added to the tumor cell culture, marked inhibition of tumor cell growth resulted. In the other case, interferon had no effect on the metastasized lung tumor.

Adolescent↗
PubMed1980

The preventive effect of human interferon-alpha preparation on upper respiratory disease.

Drops of a human leukocyte-derived interferon (HuIFN-alpha) preparation were instilled into the nasal cavity of 86 volunteers once a day from the beginning of December 1977 to the end of March 1978. The rise in hemagglutination-inhibition antibody titers against the three strains of influenza viruses was not significantly different between the interferon group and the control group. However, the rise in antibody titers against the parainfluenza virus, type 2, CA, was less in the interferon group than in the control group. There were fewer complaints of fever resulting from upper respiratory tract disease in the interferon group. Moreover, fevers higher than 39 degrees C were found only in placebo recipients. Fourteen of the 41 volunteers in the interferon group complained of subjective symptoms due to upper respiratory tract infection, whereas 28 of the 43 volunteers in the placebo group complained. This difference was significant. Thus our study indicates that prophylactic administration of an HuIFN-alpha-preparation can influence upper respiratory tract disease.

Administration, Intranasal↗
PubMed1980

Increased nitroblue tetrazolium dye reduction by human neutrophils stimulated by interferon in vitro.

Human leukocyte interferon enhanced nitroblue tetrazolium dye (NBT) reduction by human neutrophils (PMNs). Increase in NBT reduction paralleled increase in interferon dose. When human leukocyte interferon was heated to 60 C or 80 C for 30 min, both the antiviral activity and the effect on NBT reduction decreased. Human leukocyte interferon neutralized with anti-human leukocyte interferon serum showed no effect on NBT reduction. A human fibroblast interferon preparation also enhanced NBT reduction. The species dependency of interferon was shown in NBT reduction as well as in antiviral activity.

Animals↗
PubMed1980

[Effect of interferon on the inhibition of tumor cell growth by human peripheral leukocytes].

Human leukocyte interferon (HL-IF) enhanced the growth inhibition of tumor cells by the human peripheral leukocytes. There was a dose relation between the enhancement of the growth inhibition of tumor cells and the antiviral activity of interferon. When the ratio of lymphocyte to tumor cell was 10:1 or 50:1, it was recognized that HL-IF enhanced the growth inhibition of tumor cells by lymphocyte. The heterologous IFs--mouse and rabbit IFs--or heat-inactivated or trypsinized IF did not enhance the growth inhibition of tumor cells by lymphocytes. RNase treatment did not reduce the antiviral activity and the growth inhibition.

Cell Division↗