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Biomedical subjects

A Matsui

Publications and source records attributed to A Matsui.

At least 181 records · Page 10Linked to original sources
PubMed1986

Deletion 14q(q24.3 to q32.1) syndrome: significance of peculiar facial appearance in its diagnosis, and deletion mapping of Pi(alpha 1-antitrypsin).

A 10-month-old Japanese boy who had interstitial deletion of the long arm of chromosome No. 14; 46,XY, del(14)(pter----q24.3: :q32.1----qter) is reported. A peculiar facial appearance, including round face, frontal hypertrichosis with thick eyebrows, horizontal narrow palpebral fissures, a short bulbous nose with a flat nasal root, and mild micrognathia, appeared to be common with the two previously reported cases. We stress the significance of this peculiar facial appearance in the diagnosis of 14q-(q24.3 to q32.1) syndrome. The level of alpha 1-antitrypsin in the patient was only about half of that of his parents and controls, and the Pi locus was tentatively assigned to band 14q32.1.

Chromosome Banding↗
PubMed1986

Beneficial effect of chymostatin on dystrophic mice.

We studied the effect of chymostatin on dystrophic mice (C57BL/6J-dy). The locomotor activity of normal mice increased markedly, attaining a plateau at 8 weeks of age, whereas in dystrophic mice, it increased until the age of 7 weeks, and thereafter decreased gradually. Serum levels of creatine phosphokinase were significantly higher in dystrophic mice compared with normal mice, and dystrophic mice had a reduced muscle protein content. When 3-week-old dystrophic mice received chymostatin (1 mg/kg, i.p.), the decrease in locomotor activity was retarded, serum enzyme levels decreased significantly, and muscle protein content increased significantly. In addition, the survival time of treated dystrophic mice was prolonged. The locomotor activity, serum enzyme levels, and muscle protein content of normal mice were not affected by chymostatin. Therefore, we posit that chymostatin retarded the progression of dystrophy in mice.

Animals↗
PubMed1985

Two siblings with multiple intracranial haemangiomatosis with calcification.

Two siblings with multiple intracranial haemangiomatosis are reported, each having psychomotor retardation, epilepsy and gyriform type calcification in the occipital and frontal lobes. There were haemangiomas in one autopsy case with calcification in the deep layers of the cortex and subcortical white matter.

Brain Diseases↗
PubMed1985

Placental transfer of positron-emitting radionuclides in metabolic substrates.

Experimental studies on the biodistribution and placental transfer of in vivo metabolic constituents in pregnant rats were investigated with positron-emitting compounds such as 18F-2-fluoro-2-deoxyglucose, a mixture of 11C-glucose and 11C-fructose, 11C-L-methionine, 11C-D,L-leucine, 11C-adenine, 18F-5-fluoro-2'-deoxyuridine, 11C-S-adenosyl-L-methionine and 11C-coenzyme Q10. Sugars and amino acids transferred easily through the placenta and distributed into the fetal tissues to a similar extent as into the maternal tissues. The fetus-to-placenta ratios for the amino acids were always over 1.0, which indicated active transport of the amino acids in the placenta. On the contrary, other compounds have some limitation to transfer through the placenta in comparison with the sugars and amino acids. The fetus-to-placenta ratios of 11C-adenine, 11C-S-adenosyl-L-methionine and 11C-coenzyme Q10 were much less than the placenta-to-blood ratios, which indicated the presence of a certain placental barrier against these compounds. 11C-S-adenosyl-L-methionine and 11C-coenzyme Q10 were incorporated more into the fetal brain than into the maternal brain which is probably due to the nutritional requirement of the fetal brain and/or an immature blood-brain barrier.

Adenine↗
PubMed1983

Serum bile acid analysis.

Routine and research techniques are outlined for the analysis of bile acids in serum. The basis of these techniques is the use of liquid-solid extraction and liquid-gel chromatography coupled with the measurement of bile acids by gas chromatography using high resolution glass capillary columns and mass spectrometry which provides increased sensitivity compared with conventional methods of measurement. Problems associated with the isolation and purification of bile acids from serum are discussed and rapid and flexible methods for their metabolic profiling are described. The advantages and applicability of these procedures are illustrated with examples of profiles of bile acids in the serum from normal subjects, patients with liver disease and a patient with an ileal resection.

Adult↗