Possible clues to the early history of the solar system.
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Journal Article↗
Biomedical subjects
A Masuda
Publications and source records attributed to A Masuda.
Pseudoaneurysm of the superficial femoral artery in Behçet's disease with spontaneous thrombosis followed by CT angiography.
A 25-year-old man developed sudden pain and a pulsating mass in the left thigh. A diagnosis of Behçet's disease was made because of four major symptoms. Laboratory data indicated active inflammation. Emergency spiral computed tomographic angiography (CTA) showed an aneurysm of the left superficial femoral artery (SFA). Under steroid therapy, follow-up spiral CTA showed spontaneous occlusion of the aneurysm. In the active phase of arteritis, spiral CTA is useful for the diagnosis of arterial lesions to avoid the arterial puncture of conventional arteriography.
Adult↗
Spatio-temporal source modeling of evoked potentials to acoustic and cochlear implant stimulation.
Spatio-temporal source modeling (STSM) of event-related potentials was used to estimate the loci and characteristics of cortical activity evoked by acoustic stimulation in normal hearing subjects and by electrical stimulation in cochlear implant (CI) subjects. In both groups of subjects, source solutions obtained for the N1/P2 complex were located in the superior half of the temporal lobe in the head model. Results indicate that it may be possible to determine whether stimulation of different implant channels activates different regions of cochleotopically organized auditory cortex. Auditory system activation can be assessed further by examining the characteristics of the source wave forms. For example, subjects whose cochlear implants provided auditory sensations and normal hearing subjects had similar source activity. In contrast, a subject in whom implant activation evoked eyelid movements exhibited different source wave forms. STSM analysis may provide an electrophysiological technique for guiding rehabilitation programs based on the capabilities of the individual implant user and for disentangling the complex response patterns to electrical stimulation of the brain.
Acoustic Stimulation↗
Effects of a calcium channel blocker, manidipine, on insulin sensitivity in essential hypertensives.
This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic glucose clamp was performed in a fasting condition before and after 2 weeks administration of manidipine (20 mg/day). Insulin sensitivity was evaluated as M-value calculated from the infusion rate of glucose. Manidipine administration decreased mean blood pressure and increased M-value significantly in EHT. Before the manidipine treatment, hyperinsulinemia during the clamp induced a decrease of urinary sodium excretion and increases of plasma norepinephrine and plasma renin activity in EHT. After manidipine treatment, however, hyperinsulinemia induced natriuresis and did not augment the pressor systems activity. Thus, the calcium channel blocker improved insulin resistance as assessed by glucose clamp technique in EHT. Suppression of augmented renal sodium reabsorption and pressor system activities of insulin may be connected with the hypotensive mechanisms and the natriuresis caused by calcium channel blockers.
Blood Glucose↗
Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome.
The psychobehavioral responses and cellular immune function were investigated in healthy people (control, N = 21), adult people with chronic fatigue (fatigue-non-CFS group, N = 24), and patients with chronic fatigue syndrome (CFS, N = 10). Based on psychobehavioral responses, the fatigue-non-CFS group had low general activity levels (p < .05) and slightly depressive tendencies (p < .01) compared with the control. They had many life event stresses (p < .05) and sleep disturbances (p < .01), and they could not cope appropriately with stresses. The fatigue-non-CFS group also showed significantly lower natural killer (NK) cell activity (p < .01) and decreased numbers of CD16+ and CD56+ cells (p < .05). Compared with the fatigue-non-CFS group, patients with CFS had higher degrees of physical fatigue (p < .01) and more life event stresses (p < .05). They had lower general activity levels and social introversion. They were also in a depressive state. NK cell activity and the numbers of CD16+ and CD56+ cells were significantly reduced in patients with CFS (p < .01). These findings suggest that adult people with chronic fatigue may be in an intermediate state between the healthy control and patients with CFS in terms of psychobehavioral responses and low NK cell activity. We observed three cases in such an intermediate state in whom CFS subsequently developed.
Adaptation, Psychological↗
Analysis of the specificity of human antibodies to antigens of Leishmania braziliensis braziliensis.
The antigenicity of promastigotes of Leishmania braziliensis braziliensis (L. b. braziliensis) treated with 1% sodium desoxycholate in 10 mM Tris-Hcl pH 8.2 was analysed by immunoblot using as probes sera from American cutaneous leishmaniasis (ACL), American visceral leishmaniasis (AVL), schistosomiasis, malaria and Chagas' disease. The ACL sera reacted constantly with a 60 kD band. No reactivity to this protein was observed with sera from the other diseases above mentioned indicating that the 60 kD protein may be used in serodiagnosis for ACL.
Animals↗
Pituitary adenoma results in the empty sella syndrome.
A 69-year-old female was treated for hyperthyroidism and hypertension. In August 1984, she suddenly began suffering from polyuria and polydipsia. In October, she exhibited fever, headache, vertigo, and poor appetite, probably due to pituitary apoplexy. Her endocrine function was normal, except for partial diabetes insipidus. A contrast-enhanced CT brain scan revealed a pituitary adenoma with a ring-enhanced outer edge and a central low-density area. The MRI scan also indicated cystic adenoma. A CT scan examination repeated 6 months later showed an empty sella with a markedly decreased pituitary adenoma. This case report demonstrates that some empty sella are the final result of pituitary adenoma bleeding or infarction.
Adenoma↗
Development of thermotolerance in hsp70 induction-defective mutant of NRK cells.
We investigated the relation between the synthesis of inducible form of heat-shock protein 70 (hsp70) and the development of thermotolerance using NRK (normal rat kidney) cells and their mutant cell line (39-1 cells). In NRK cells, hsp70 was clearly induced by conditioning treatments (42 degrees C for 2 h, 45 degrees C for 15 min or 100 microM sodium arsenite for 1 h). On the other hand, the induction of hsp70 in 39-1 cells was very low or not detectable by these treatments. Other high molecular weight hsps, hsc70 (constitutive form), hsp90 and hsp110 were induced in both cell lines. However, thermotolerance as defined by clonogenic survival was induced in both cell lines to a similar extent by the conditioning treatments. When cells were made thermotolerant by conditioning heating at 45 degrees C for 15 min, the inhibition of protein synthesis after challenge (second) heating was less in NRK cells than in 39-1 cells. This indicated that the extent of 'translational thermotolerance' was much higher in NRK cells than in 39-1 cells. From these results, it is suggested that the synthesis of inducible hsp70 is involved in the translational thermotolerance rather than the development of thermotolerance as defined by clonogenic survival.
Animals↗
The association between splenomegaly and malaria in Indians from the Alto Xingu, central Brasil.
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Adolescent↗
Myocardial protection during open-heart surgery: preservation of myocardial metabolism and ultrastructure by cold coronary perfusion.
Myocardial protection by means of selective, continuous coronary perfusion with cold oxygenated blood of low flow rate and of low perfusion pressure is an excellent procedure both clinically and experimentally. This method should be particularly useful in poor-risk patients, for whom a maximal preservation of the myocardium is imperative.
Animals↗