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Biomedical subjects

A Marusic

Publications and source records attributed to A Marusic.

30 records · Page 2Linked to original sources
PubMed2000

Factor analysis of risk for coronary heart disease: an independent replication.

Eleven risk factors for coronary heart disease were measured on 187 patients with and 187 patients without this disease. Next, factor analysis was performed to identify underlying variables, or factors, that explain the pattern of correlations within a set of observed risk factors. The factor analysis disclosed four factors that explained almost 55% of the variance: a dyslipidaemic and haemostatic complex, a pure hypercholesterolaemia, the metabolic syndrome X, and positive family and medical histories. The four extracted patterns of risk factors did not replicate previous factor analyses of coronary heart disease risk factors, in which the family history of coronary disease on one side and a generalised lack of self-control on the other were suggested. They, however, generated some understanding regarding coronary heart disease risk factors' interactions. Also, results of the present study do encourage efforts to explore new methods designated to bring about more basic forms of personality reorganisation in the realm of self-control, which could in turn have a positive impact on risk factors profile, health status and mortality.

Aged↗
PubMed2000

Search for the CP forbidden decay eta-->4pi(0)

We report the first determination of the upper limit for the branching ratio of the CP forbidden decay eta-->4pi(0). No events were observed in a sample of 3.0x10(7) eta decays. The experiment was performed with the Crystal Ball multiphoton spectrometer installed in a separated pi(-) beam at the AGS (Alternating Gradient Synchrotron). At the 90% confidence limit, B(eta-->4pi(0))</=6. 9x10(-7).

Journal Article↗
PubMed2000

Role of B lymphocytes in new bone formation.

Although there may be a close relationship between B lymphocytes and osteoclasts, or bone resorbing cells, little is known about the role of B lymphocytes in bone formation. We compared in vivo new bone induction in mice homozygous for the B-cell deficient (microMT) gene knockout, which lack functional B lymphocytes, with bone induction in control wild-type (C57BL/6) mice. Our comparison used two models of new bone induction in vivo: endochondral osteoinduction by subcutaneous implantation of recombinant human bone morphogenetic protein (rhBMP-2) and osteogenic regeneration after tibial bone marrow ablation. The expression of bone-specific proteins (bone sialoprotein, osteopontin, and osteocalcin) and inflammatory/immunomodulatory cytokines (interleukin-1alpha and -1beta, interleukin-6, and tumor necrosis factor-alpha) was assessed by Northern blot analysis or reverse transcription-polymerase chain reaction, respectively. Ossicles induced by rhBMP-2 were larger in volume and mass in microMT knockout mice, but relative volumes of the newly induced bone, cartilage, and bone marrow were similar in the two groups. Six days after tibial bone marrow ablation, microMT knockout mice resorbed the initial blood clot faster and formed more trabecular bone, paralleled by greater levels of bone sialoprotein mRNA than in the wild-type mice. microMT knockout and wild-type mice also differed in the expression pattern of inflammatory/immunomodulatory cytokines during the development of the newly induced bone, suggesting that a genetic lack of B lymphocytes may create a change in the immunological milieu at the site of new bone induction, which stimulates the initial accumulation and proliferation of mesenchymal progenitor.

Animals↗
PubMed2000

Immunohistological and flow cytometric analysis of glycosphingolipid expression in mouse lymphoid tissues.

Expression of neutral glycosphingolipids (GSLs) and gangliosides in normal lymphoid tissues and cells has been studied mostly by biochemical and immunochemical analysis of lipid extracts separated by thin-layer chromatography. GSLs and gangliosides involved in the GM1b biosynthetic pathway were assigned to T-lymphocytes, whereas B-cell gangliosides and GSLs have been poorly characterized in former publications. We used specific polyclonal antibodies in immunohistochemistry and flow cytometry to analyze the distribution of globotriaosylceramide (Gb(3)Cer), globoside (Gb(4)Cer), gangliotriaosylceramide (Gg(3)Cer), gangliotetraosylceramide (Gg(4)Cer), and gangliosides GM3 and GalNAc-GM1b in the mouse thymus, spleen, and lymph node. Immature thymocytes expressed epitopes recognized by all antibodies, except for anti-Gb(4)Cer. Mature thymocytes bound only antibodies to GalNAc-GM1b, Gg(4)Cer, and Gb(4)Cer. In secondary lymphoid organs, antibodies to globo-series GSLs bound to vascular spaces of secondary lymphoid organs, whereas the ganglio-series GSL antibodies recognized lymphocyte-containing regions. In a Western blotting analysis, only GalNAc-GM1b antibody recognized a specific protein band in all three organs. Flow cytometric analysis of spleen and lymph node cells revealed that B-cells carried epitopes recognized by all antibodies, whereas the T-cell GSL repertoire was mostly oriented to ganglio-series-neutral GSLs and GM1b-type gangliosides. The results of immunohistochemistry and flow cytometry were not always identical, possibly because of crossreactivity to glycoprotein-linked oligosaccharides and/or differences between cell surface carbohydrate profiles of isolated cells and cells in a tissue environment.

Animals↗
PubMed1999

Small scientific journals from small countries: breaking from a vicious circle of inadequacy.

In this editorial we describe the confounding factors that contribute to the poor international recognition of small journals: author pool, review process, finances, language, and visibility. These factors originate from relative scientific inadequacy of the local environment and close a positive feedback loop (vicious circle) of journal inadequacy. We argue that small journals may provide important information and outline the ways in which they can be assisted.

Croatia↗
PubMed1998

Suicide mortality in Slovenia: regional variation.

Different medical, social, and environmental regional characteristics were investigated as possible predictors of suicide rates in 60 self-governing communes in Slovenia. The distribution pattern of regional suicide rates for Slovenia shows some similarity to that of the rest of Europe, especially in terms of the substantial variation of suicide density within the country. On the basis of the multivariate analysis, prevalence of alcohol psychosis, percentage of Catholics, and low duration of sunshine appeared to be the most important predictors of regional suicide rates in Slovenia. The rate of murders was proven to be a highly useful clue of suicide potential among younger groups, whereas income per capita of population was associated with suicide risk in old age. The principal component analysis provided three suicide risk patterns: a socio-economic risk pattern (Catholic religion in poor community), a behavioral one (antisocial features, including heavy drinking), and a depression-related risk pattern with a climatic component (lack of sunshine). Different approaches are necessary for the different risk patterns listed above. Psychiatry, especially clinical psychiatry, can only deal with components of two of the patterns, namely, depression and antisocial behavior.

Adolescent↗
PubMed1995

Rapid high-performance liquid chromatographic determination of vancomycin in human plasma.

A rapid simple and robust reversed-phase HPLC method was developed for rapid screening in bioavailability studies or comparative bioequivalence studies. The method is specific for vancomycin as no interference from acetylsalicylic acid, paracetamol and caffeine was observed. The mean intra-day precision was from 11.7% (low concentration) to 0.3% (high concentration) and the within-day precision from 15.0 to 0.3%, determined on spiked samples. The accuracy of the method was 106.4-99.8% (intra-day) and 103.5-100.2% (inter-day).

Acetaminophen↗
PubMed1995

Rape, torture, and traumatization of Bosnian and Croatian women: psychological sequelae.

The first 25 Bosnian women admitted to the Zagreb Obstetrics and Gynaecological Clinic or its associated regional psychiatric centers were assessed using both clinical and post-traumatic stress disorder interviews. Most of the women had been multiply traumatized; all had been repeatedly raped. Psychological status was assessed for those women who were not impregnated, for those impregnated who received abortions, and for those impregnated who carried the fetus to term.

Abortion, Induced↗
PubMed1985

HPLC method for determination of ergot alkaloids and some derivatives in human plasma.

Ergot alkaloids and their dihydrogenated methanesulphonate (ms) salts were determined and measured in human plasma. High-performance liquid chromatography (HPLC) with fluorometric detection was used for separation of ergot alkaloids in plasma. Several ergot alkaloids and their derivatives, including lysergide (LSD), can be identified in cases of poisoning.

Chromatography, High Pressure Liquid↗