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Biomedical subjects

A Martini

Publications and source records attributed to A Martini.

At least 469 records · Page 26Linked to original sources
PubMedDate not supplied

Auditory brainstem evoked responses in the clinical evaluation and follow-up of insulin-dependent diabetic subjects.

In the last few years the use of ABR in the dysmetabolic encephalopathies has aroused considerable interest. Even though brainstem involvement in these syndromes is not yet entirely understood, ABR techniques have provided new and important insights. We studied 60 insulin-dependent diabetic subjects, 29 females and 31 males aged to 17 to 55 yrs, and observed ABR abnormalities in 28.2% of the cases. This impairment affects the I-V interval or central transmission time (CTT), which is considered the most reliable index of brainstem function. The ABR pattern was considered pathologic when the CTT was due 2DS as compared with a sex- and age-matched control. Follow-up studies performed on 20 of these subjects revealed no significant variation in the ABR tracing. This fact, together with the absence or correlation between ABR involvement and metabolic control and glycemia level during the test, could be attributed to a 'structural' damage of the brainstem tissue. In diabetics, we observed a significant correlation (p less than 0.05) between I-V interval shift and an EMG-proved reduction in motor conduction velocity (MCV) of the peroneal nerve. We also found a high incidence of ABR impairment (53%) in diabetics with cardiovascular autonomic failure.

Adolescent↗
PubMedDate not supplied

Desynchronized EEG activity in a case of post-traumatic coma.

The EEG pattern of diffused low-voltage non-reacting fast activity is exceptional in comatose patients. The authors report on clinical observations, CT scan and neurophysiological findings in one case showing this EEG pattern after a severe head injury. In serial EEG recording it is shown a progressive shift from fast activity towards the alpha and theta bands. The presence of abnormal auditory brainstem responses and of CT scan signs of brainstem lesion suggest that this peculiar EEG pattern may be due to a brainstem lesion.

Brain Injuries↗
PubMedDate not supplied

Importance of auditory brainstem responses in the CT diagnosis of traumatic brainstem lesions.

Changes in brainstem auditory-evoked potential response were serially investigated in 20 head-injury patients with neurologic and computed tomographic signs of brainstem lesion. The reliability of computed tomography in the evaluation of indirect signs of brainstem lesion from the image was investigated with elaboration of the brainstem auditory-evoked potential response. The measurement of auditory brainstem response is thought to be useful in detecting the severity and predicting possible recovery in posttraumatic brainstem injury. Brainstem deformity on computed tomography was a bad prognostic sign, indicating irreversible structural change.

Adolescent↗
PubMedDate not supplied

Studies on the comparative distribution and biliary excretion of doxorubicin and 4'-epi-doxorubicin in mice and rats.

Serum and tissue distribution of doxorubicin (DX) and its stereoisomer, 4'-epidoxorubicin (4'-epiDX), after iv injection of 15 mg/kg was investigated in C57BL mice bearing 14-day intramuscular Lewis lung carcinoma. Total fluorescence was measured together with unchanged drugs, separated, and quantitated by means of thin-layer chromatography combined with a scanning fluorescence technique. In serum the disappearance of 4'-epiDX paralleled that of DX and both unchanged isomers represented < 50% of the total fluorescence measured as early as 30 minutes after drug injection. In tissues the fluorescence measured was almost completely accounted for by the native compounds, both DX and 4'-epiDX, indicating that these drugs are taken up as such by tissues. 4'-EpiDX levels were markedly lower than those of DX in tumor and spleen, whereas in heart, liver, and kidneys the concentrations of the two isomers were the same. Traces of doxorubicinol and possibly 4'-epidoxorubicinol were detected only in serum, liver, and kidneys. Comparative cumulative biliary excretion of DX and 4'-epiDX investigated in the rat indicated that a total of 40%-45% of the injected dose of both drugs was excreted either as unchanged compound or as reduced metabolite. However, the proportions were different and the presence of twice as much reduced metabolite and smaller amounts of native 4'-epiDX suggests that its metabolic rate is different from that of DX

Animals↗